Cohort profile: the Swedish Maternal Microbiome project (SweMaMi) - assessing the dynamic associations between the microbiome and maternal and neonatal adverse events.
bacteriology
fetal medicine
maternal medicine
microbiology
public health
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
26 10 2022
26 10 2022
Historique:
entrez:
26
10
2022
pubmed:
27
10
2022
medline:
29
10
2022
Statut:
epublish
Résumé
The Swedish Maternal Microbiome (SweMaMi) project was initiated to better understand the dynamics of the microbiome in pregnancy, with longitudinal microbiome sampling, shotgun metagenomics, extensive questionnaires and health registry linkage. Pregnant women were recruited before the 20th gestational week during 2017-2021 in Sweden. In total, 5439 pregnancies (5193 unique women) were included. For 3973 pregnancies (73%), samples were provided at baseline, and for 3141 (58%) at all three timepoints (second and third trimester and postpartum). In total, 38 591 maternal microbiome samples (vaginal, faecal and saliva) and 3109 infant faecal samples were collected. Questionnaires were used to collect information on general, reproductive and mental health, diet and lifestyle, complemented by linkage to the nationwide health registries, also used to follow up the health of the offspring (up to age 10). The cohort is fairly representative for the total Swedish pregnant population (data from 2019), with 41% first-time mothers. Women with university level education, born in Sweden, with normal body mass index, not using tobacco-products and aged 30-34 years were slightly over-represented. The sample and data collection were finalised in November 2021. The next steps are the characterisation of the microbial DNA and linkage to the health and demographic information from the questionnaires and registries. The role of the microbiome on maternal and neonatal outcomes and early-childhood diseases will be explored (including preterm birth, miscarriage) and the role and interaction of other risk factors and confounders (including endometriosis, polycystic ovarian syndrome, diet, drug use). This is currently among the largest pregnancy cohorts in the world with longitudinal design and detailed and standardised microbiome sampling enabling follow-up of both mothers and children. The findings are expected to contribute greatly to the field of reproductive health focusing on pregnancy and neonatal outcomes.
Identifiants
pubmed: 36288838
pii: bmjopen-2022-065825
doi: 10.1136/bmjopen-2022-065825
pmc: PMC9615996
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e065825Informations de copyright
© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: The Centre for Translational Microbiome Research (CTMR) and associated authors are partly funded by Ferring Pharmaceuticals.
Références
Acta Obstet Gynecol Scand. 2015 Jul;94(7):766-775
pubmed: 25846179
Nat Commun. 2022 Feb 21;13(1):975
pubmed: 35190561
mBio. 2019 Aug 13;10(4):
pubmed: 31409678
Front Endocrinol (Lausanne). 2022 Jul 05;13:908868
pubmed: 35865314
Transl Pediatr. 2021 Apr;10(4):819-833
pubmed: 34012831
Cell. 2012 Aug 3;150(3):470-80
pubmed: 22863002
Immunity. 2022 Jan 11;55(1):145-158.e7
pubmed: 34879222
Prog Urol. 2014 Sep;24(11):708-13
pubmed: 25214452
J Reprod Immunol. 2021 Jun;145:103293
pubmed: 33676065
Obstet Gynecol. 2019 Sep;134(3):527-536
pubmed: 31403584
Nature. 2012 Jun 13;486(7402):207-14
pubmed: 22699609
Am J Obstet Gynecol. 2019 Jul;221(1):9-18.e8
pubmed: 30550767
Hum Reprod. 2019 Jun 4;34(6):1042-1054
pubmed: 31119299
Microbiome. 2014 Feb 03;2(1):4
pubmed: 24484853
Lancet. 2002 Jul 13;360(9327):151-9
pubmed: 12126838
BMC Oral Health. 2022 Jun 28;22(1):260
pubmed: 35764953
Front Public Health. 2020 Jul 24;8:326
pubmed: 32793540
Sci Rep. 2022 May 13;12(1):7926
pubmed: 35562576
Sci Rep. 2021 Aug 19;11(1):16870
pubmed: 34413437
Microbiome. 2017 Sep 4;5(1):113
pubmed: 28870230
J Obstet Gynaecol Res. 2017 Jan;43(1):16-22
pubmed: 28074549
Clin Biochem. 2018 Dec;62:2-10
pubmed: 29555319
Microorganisms. 2021 Feb 25;9(3):
pubmed: 33668738
Pregnancy Hypertens. 2021 Mar;23:211-219
pubmed: 33530034
Front Microbiol. 2016 Jul 14;7:1031
pubmed: 27471494
Acta Oncol. 2009;48(1):27-33
pubmed: 18767000
J Clin Endocrinol Metab. 1961 Nov;21:1440-7
pubmed: 13892577
Nat Med. 2019 Jun;25(6):1012-1021
pubmed: 31142849
Int J Womens Health. 2017 Aug 08;9:551-559
pubmed: 28848365
J Clin Endocrinol Metab. 2021 Sep 27;106(10):e4128-e4141
pubmed: 34015117
NPJ Biofilms Microbiomes. 2020 Oct 12;6(1):39
pubmed: 33046723
J Health Soc Behav. 1983 Dec;24(4):385-96
pubmed: 6668417
PeerJ. 2019 Nov 21;7:e8004
pubmed: 31772833
Adv Neonatal Care. 2015 Dec;15(6):377-85
pubmed: 26317856
BMJ. 2017 Mar 15;356:j831
pubmed: 28298355
BMC Med. 2022 Jan 28;20(1):38
pubmed: 35090453
Fertil Steril. 2015 Dec;104(6):1358-63
pubmed: 26493119
Semin Fetal Neonatal Med. 2016 Apr;21(2):94-9
pubmed: 26936188
Front Cell Infect Microbiol. 2021 Mar 19;11:625229
pubmed: 33816334
Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4680-7
pubmed: 20534435
Am J Perinatol. 2018 Jan;35(1):24-30
pubmed: 28750469
Eur J Epidemiol. 2017 Sep;32(9):765-773
pubmed: 28983736
Nat Biotechnol. 2020 Sep;38(9):1079-1086
pubmed: 32341564
J Clin Microbiol. 2010 May;48(5):1741-8
pubmed: 20200290
Front Cell Infect Microbiol. 2020 May 15;10:188
pubmed: 32500037
Acta Obstet Gynecol Scand. 2018 Apr;97(4):466-476
pubmed: 29172245
Microbiome. 2017 Mar 9;5(1):31
pubmed: 28274256
BMJ. 2011 Oct 13;343:d6309
pubmed: 21998337
PLoS One. 2014 Aug 22;9(8):e105998
pubmed: 25148517
Endocr Connect. 2021 Oct 19;10(11):1366-1376
pubmed: 34559065
Reprod Sci. 2021 Jul;28(7):1996-2005
pubmed: 33432532
Curr Opin Microbiol. 2020 Aug;56:30-37
pubmed: 32634598
Br J Psychiatry. 1987 Jun;150:782-6
pubmed: 3651732
Med (N Y). 2021 Sep 10;2(9):1027-1049
pubmed: 34617072
J Bacteriol. 2010 Oct;192(19):5002-17
pubmed: 20656903
mSphere. 2020 Nov 18;5(6):
pubmed: 33208514
Clin Evid. 2005 Jun;(13):1968-78
pubmed: 16135317
J Anim Sci Biotechnol. 2019 Nov 11;10:88
pubmed: 31737268
Gut Microbes. 2020 Nov 9;12(1):1-13
pubmed: 33222612
Sci Rep. 2015 Mar 11;5:8988
pubmed: 25758319
Brain Behav Immun. 2019 Jan;75:240-250
pubmed: 30399404
NPJ Biofilms Microbiomes. 2020 Sep 11;6(1):32
pubmed: 32917878
Nat Commun. 2019 Mar 21;10(1):1305
pubmed: 30899005
Birth Defects Res C Embryo Today. 2015 Dec;105(4):252-64
pubmed: 26663857
J Obstet Gynaecol Can. 2009 Sep;31(9):803-807
pubmed: 19941704
MCN Am J Matern Child Nurs. 2017 Nov/Dec;42(6):310-317
pubmed: 28787280
Front Cell Infect Microbiol. 2019 Jun 26;9:224
pubmed: 31297341
BMC Public Health. 2011 Jun 09;11:450
pubmed: 21658213
Science. 2016 Apr 29;352(6285):560-4
pubmed: 27126039
BMC Oral Health. 2021 Jul 24;21(1):373
pubmed: 34301237
Sci Rep. 2016 Jul 27;6:30388
pubmed: 27461975
Acta Obstet Gynecol Scand. 2003 Jun;82(6):491-2
pubmed: 12780418
Gastroenterol Clin North Am. 2019 Sep;48(3):331-342
pubmed: 31383274
Pharmacoepidemiol Drug Saf. 2007 Jul;16(7):726-35
pubmed: 16897791
Hum Reprod. 2022 Jun 30;37(7):1525-1543
pubmed: 35553675