Stereoselectivity in the Membrane Transport of Phenylethylamine Derivatives by Human Monoamine Transporters and Organic Cation Transporters 1, 2, and 3.
chiral HPLC
monoamine transporters
neurotransmitter transport
organic cation transporters
phenylethylamines
stereoselective drug transport
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
18 Oct 2022
18 Oct 2022
Historique:
received:
17
09
2022
revised:
12
10
2022
accepted:
13
10
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
29
10
2022
Statut:
epublish
Résumé
Stereoselectivity is well known and very pronounced in drug metabolism and receptor binding. However, much less is known about stereoselectivity in drug membrane transport. Here, we characterized the stereoselective cell uptake of chiral phenylethylamine derivatives by human monoamine transporters (NET, DAT, and SERT) and organic cation transporters (OCT1, OCT2, and OCT3). Stereoselectivity differed extensively between closely related transporters. High-affinity monoamine transporters (MATs) showed up to 2.4-fold stereoselective uptake of norepinephrine and epinephrine as well as of numerous analogs. While NET and DAT preferentially transported
Identifiants
pubmed: 36291716
pii: biom12101507
doi: 10.3390/biom12101507
pmc: PMC9599461
pii:
doi:
Substances chimiques
Organic Cation Transporter 1
0
Octopamine
14O50WS8JD
Synephrine
PEG5DP7434
Membrane Transport Proteins
0
Cations
0
Norepinephrine
X4W3ENH1CV
Epinephrine
YKH834O4BH
Phenylephrine
1WS297W6MV
Catecholamines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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