Role of STAR and SCP2/SCPx in the Transport of Cholesterol and Other Lipids.

Carrier Proteins / metabolism Cholesterol / metabolism Biological Transport Mitochondria / metabolism
cholesterol cholesterol transport steroidogenic acute regulatory protein sterol carrier protein 2 sterol carrier protein-x

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
11 Oct 2022
Historique:
received: 07 09 2022
revised: 30 09 2022
accepted: 08 10 2022
entrez: 27 10 2022
pubmed: 28 10 2022
medline: 29 10 2022
Statut: epublish

Résumé

Cholesterol is a lipid molecule essential for several key cellular processes including steroidogenesis. As such, the trafficking and distribution of cholesterol is tightly regulated by various pathways that include vesicular and non-vesicular mechanisms. One non-vesicular mechanism is the binding of cholesterol to cholesterol transport proteins, which facilitate the movement of cholesterol between cellular membranes. Classic examples of cholesterol transport proteins are the steroidogenic acute regulatory protein (STAR; STARD1), which facilitates cholesterol transport for acute steroidogenesis in mitochondria, and sterol carrier protein 2/sterol carrier protein-x (SCP2/SCPx), which are non-specific lipid transfer proteins involved in the transport and metabolism of many lipids including cholesterol between several cellular compartments. This review discusses the roles of STAR and SCP2/SCPx in cholesterol transport as model cholesterol transport proteins, as well as more recent findings that support the role of these proteins in the transport and/or metabolism of other lipids.

Identifiants

DOI: 10.3390/ijms232012115 PMID: 36292972 PMC: PMC9602805
pubmed: 36292972
pii: ijms232012115
doi: 10.3390/ijms232012115
pmc: PMC9602805
pii:
doi:

Substances chimiques

sterol carrier proteins 0
Carrier Proteins 0
Cholesterol 97C5T2UQ7J

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : John Stauffer Decanal Chair in Pharmaceutical Sciences, University of Southern California
ID : N/A

Références

Endocr Rev. 2003 Jun;24(3):357-87
pubmed: 12788804
Biology (Basel). 2015 Mar 04;4(1):200-15
pubmed: 25749137
J Clin Invest. 2002 Oct;110(7):881-90
pubmed: 12370263
Nat Rev Mol Cell Biol. 2020 Apr;21(4):225-245
pubmed: 31848472
J Biol Chem. 1997 Dec 19;272(51):32656-62
pubmed: 9405483
J Biol Chem. 2007 Apr 6;282(14):10223-32
pubmed: 17301050
J Biol Chem. 2012 May 4;287(19):15380-94
pubmed: 22427666
J Steroid Biochem Mol Biol. 1993 Dec;47(1-6):167-72
pubmed: 8274432
Am J Physiol. 1998 Aug;275(2):G237-43
pubmed: 9688650
Genes Dev. 1998 Apr 15;12(8):1189-201
pubmed: 9553048
Front Biosci (Landmark Ed). 2014 Jan 01;19(3):416-28
pubmed: 24389193
Mol Endocrinol. 2005 Feb;19(2):540-54
pubmed: 15498831
J Endocrinol. 1986 Jun;109(3):R13-6
pubmed: 3734663
Proc Natl Acad Sci U S A. 2002 May 14;99(10):6949-54
pubmed: 12011453
Biochem J. 1996 Aug 1;317 ( Pt 3):681-7
pubmed: 8760350
Mol Cell Endocrinol. 2011 Apr 10;336(1-2):70-9
pubmed: 21147195
Nature. 2002 May 2;417(6884):87-91
pubmed: 11986670
Proc Natl Acad Sci U S A. 1991 Jan 15;88(2):463-7
pubmed: 1703300
Biochemistry. 2001 May 29;40(21):6493-506
pubmed: 11371213
Biol Reprod. 2008 Feb;78(2):267-77
pubmed: 17989356
J Cell Biol. 1989 Apr;108(4):1353-61
pubmed: 2925789
Cancer Res. 2016 Apr 15;76(8):2063-70
pubmed: 27197250
Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7250-5
pubmed: 10377400
J Cell Biol. 1985 Aug;101(2):446-53
pubmed: 4040520
J Lipid Res. 2000 Nov;41(11):1728-39
pubmed: 11060342
Mol Endocrinol. 2007 Mar;21(3):589-601
pubmed: 16973755
Future Med Chem. 2015;7(18):2451-67
pubmed: 26669800
Nutr Metab (Lond). 2010 Jun 01;7:47
pubmed: 20515451
Prog Lipid Res. 2001 Nov;40(6):498-563
pubmed: 11591437
Biochim Biophys Acta. 2007 Jun;1771(6):663-76
pubmed: 17433772
J Lipid Res. 1991 Feb;32(2):329-39
pubmed: 2066666
Am J Physiol Cell Physiol. 2000 Oct;279(4):C1259-69
pubmed: 11003606
Endocr Res. 2002 Nov;28(4):295-308
pubmed: 12530629
J Biol Chem. 1995 Aug 11;270(32):18723-6
pubmed: 7642518
PLoS One. 2016 Feb 22;11(2):e0149728
pubmed: 26901662
J Biol Chem. 1999 Dec 10;274(50):35425-33
pubmed: 10585412
Mol Endocrinol. 1995 Oct;9(10):1346-55
pubmed: 8544843
Proc Natl Acad Sci U S A. 1995 May 23;92(11):4778-82
pubmed: 7761400
Mol Endocrinol. 2003 Dec;17(12):2461-76
pubmed: 12958217
J Biol Chem. 1991 Oct 15;266(29):19739-45
pubmed: 1655794
J Biol Chem. 1986 Jun 5;261(16):7322-6
pubmed: 3011782
Mol Cell Biochem. 1999 Feb;192(1-2):95-103
pubmed: 10331663
Biochem Biophys Res Commun. 1985 Feb 28;127(1):333-8
pubmed: 3977925
Nat Rev Mol Cell Biol. 2010 Oct;11(10):739-50
pubmed: 20823909
J Biol Chem. 1981 Jun 25;256(12):5988-91
pubmed: 6894595
J Biol Chem. 1982 Aug 10;257(15):8928-34
pubmed: 7096342
Trends Cell Biol. 2010 Nov;20(11):680-7
pubmed: 20843692
J Biol Chem. 1994 Aug 19;269(33):21277-83
pubmed: 8063752
Hum Mol Genet. 1995 Dec;4(12):2299-305
pubmed: 8634702
Endocrinology. 2022 Aug 1;163(8):
pubmed: 35704520
Am J Physiol Gastrointest Liver Physiol. 2007 Mar;292(3):G939-51
pubmed: 17068117
Endocrinology. 1992 Dec;131(6):2839-45
pubmed: 1446622
J Mol Endocrinol. 2002 Dec;29(3):327-45
pubmed: 12459035
J Biol Chem. 1997 Dec 19;272(51):32129-35
pubmed: 9405411
Biochim Biophys Acta. 2009 Jul;1791(7):646-58
pubmed: 19286473
Mol Cell Endocrinol. 2002 May 31;191(1):19-25
pubmed: 12044915
J Biol Chem. 1987 Mar 15;262(8):3713-7
pubmed: 3029121
Annu Rev Pharmacol Toxicol. 2016;56:447-67
pubmed: 26738477
Endocr Res. 1998 Aug-Nov;24(3-4):463-8
pubmed: 9888526
Science. 1995 Mar 24;267(5205):1828-31
pubmed: 7892608
J Biol Chem. 1994 Nov 11;269(45):28314-22
pubmed: 7961770
J Biol Chem. 1990 Feb 5;265(4):1919-23
pubmed: 2153669
J Lipid Res. 1999 Aug;40(8):1371-83
pubmed: 10428973
J Lipid Res. 2000 May;41(5):788-96
pubmed: 10787439
Am J Hum Genet. 2006 Jun;78(6):1046-52
pubmed: 16685654
Proc Natl Acad Sci U S A. 1991 May 15;88(10):4338-42
pubmed: 2034675
Lipids. 2007 Oct;42(10):871-84
pubmed: 17680294
Biophys J. 1998 Oct;75(4):1915-25
pubmed: 9746532
J Biol Chem. 2008 Apr 4;283(14):8837-45
pubmed: 18250166
Mol Endocrinol. 2001 Dec;15(12):2211-28
pubmed: 11731621
J Biol Chem. 1998 Oct 9;273(41):26285-8
pubmed: 9756854
J Biol Chem. 1996 Jul 5;271(27):16075-83
pubmed: 8663152
Biochemistry. 1991 Nov 26;30(47):11280-5
pubmed: 1659897
Biol Reprod. 2005 Aug;73(2):244-55
pubmed: 15814901
J Biol Chem. 1982 Dec 10;257(23):14256-62
pubmed: 6815192
Chem Phys Lipids. 2016 Sep;199:74-93
pubmed: 26874289
Chem Phys Lipids. 2000 Mar;105(1):9-29
pubmed: 10727111
Cold Spring Harb Perspect Biol. 2012 Oct 01;4(10):
pubmed: 23028121
Biochemistry. 1995 Aug 22;34(33):10660-8
pubmed: 7654720
Gastroenterology. 2000 Dec;119(6):1708-19
pubmed: 11113092
Endocrinology. 1989 Sep;125(3):1337-44
pubmed: 2474437
J Lipid Res. 2003 Sep;44(9):1751-62
pubmed: 12810824
Arterioscler Thromb Vasc Biol. 2004 Jul;24(7):1150-60
pubmed: 15130918
Biochemistry. 2005 Apr 19;44(15):5816-26
pubmed: 15823040
J Endocrinol. 2012 Mar;212(3):257-75
pubmed: 21965545
Biochem Biophys Res Commun. 1966 Jul 6;24(1):10-7
pubmed: 5966391
Harvey Lect. 1952-1953;48:68-88
pubmed: 13142481
J Lipid Res. 1999 Apr;40(4):610-22
pubmed: 10191285
Endocr Rev. 1996 Jun;17(3):221-44
pubmed: 8771357
Biochemistry. 1995 Sep 19;34(37):11919-27
pubmed: 7547928
Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11540-5
pubmed: 9326645
J Biol Chem. 2000 Nov 24;275(47):36852-61
pubmed: 10954705
J Biol Chem. 2001 Dec 7;276(49):46583-96
pubmed: 11579102
Nature. 1990 Feb 1;343(6257):425-30
pubmed: 1967820
J Biol Chem. 1997 Mar 7;272(10):6490-8
pubmed: 9045674
Annu Rev Cell Dev Biol. 2006;22:129-57
pubmed: 16753029
Atherosclerosis. 2011 Aug;217(2):299-307
pubmed: 21741044
J Lipid Res. 2010 Nov;51(11):3174-84
pubmed: 20656919
J Biol Chem. 2001 Oct 5;276(40):36970-82
pubmed: 11489878
Mol Endocrinol. 2012 Nov;26(11):1868-82
pubmed: 22973050
J Cell Biochem. 1996 Dec 1;63(3):366-73
pubmed: 8913888
Best Pract Res Clin Endocrinol Metab. 2012 Dec;26(6):771-90
pubmed: 23168279
Adv Lipid Res. 1987;22:83-113
pubmed: 3328490
Int J Mol Sci. 2021 Feb 18;22(4):
pubmed: 33670702
J Biol Chem. 1991 Oct 15;266(29):19731-8
pubmed: 1918079
Hum Genomics. 2022 Aug 22;16(1):32
pubmed: 35996156
J Biol Chem. 2006 Dec 15;281(50):38879-93
pubmed: 17050526
Lipids. 1996 Sep;31(9):895-918
pubmed: 8882970
Biochemistry. 2003 Mar 25;42(11):3189-202
pubmed: 12641450
Mol Cell Endocrinol. 2013 May 22;371(1-2):34-46
pubmed: 23246788
Eur J Biochem. 1967 Oct;2(3):275-85
pubmed: 6078538
Biochim Biophys Acta. 1997 Apr 21;1345(3):283-92
pubmed: 9150248
Nat Struct Biol. 2000 May;7(5):408-14
pubmed: 10802740
J Biol Chem. 1981 Dec 25;256(24):12719-24
pubmed: 7309733
Mol Cell Endocrinol. 2003 Apr 28;202(1-2):59-65
pubmed: 12770731
Biochim Biophys Acta. 2008 Jul-Aug;1778(7-8):1576-82
pubmed: 18423371
Biochim Biophys Acta. 1996 Jul 26;1302(2):110-6
pubmed: 8695660
J Lipid Res. 2009 Nov;50(11):2139-47
pubmed: 19357427
Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13731-6
pubmed: 8943003
Biochem Biophys Res Commun. 1997 Jul 30;236(3):565-9
pubmed: 9245689
Biochim Biophys Acta. 1999 Apr 19;1438(1):19-37
pubmed: 10216277
Nature. 2005 Dec 1;438(7068):612-21
pubmed: 16319881
Nat Rev Mol Cell Biol. 2019 Feb;20(2):85-101
pubmed: 30337668
Lipids. 1995 Sep;30(9):795-803
pubmed: 8577222
Neurology. 2015 Nov 24;85(21):1909-11
pubmed: 26497993

Auteurs

Melanie Galano (M)

Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA.

Sathvika Venugopal (S)

Department of Medicine, The Research Institute of the McGill University Health Centre, McGill University, Montreal, QC H4A 3J1, Canada.

Vassilios Papadopoulos (V)

Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA.
Department of Medicine, The Research Institute of the McGill University Health Centre, McGill University, Montreal, QC H4A 3J1, Canada.
ORCID: 0000-0002-1183-8568

Articles similaires

Pathogenic mitochondrial DNA mutations inhibit melanoma metastasis.

Spencer D Shelton, Sara House, Luiza Martins Nascentes Melo et al.
1.00
DNA, Mitochondrial Humans Melanoma Mutation Neoplasm Metastasis

A dual role for PSIP1/LEDGF in T cell acute lymphoblastic leukemia.

Lisa Demoen, Filip Matthijssens, Lindy Reunes et al.
1.00
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Animals Mice Humans Cell Line, Tumor

Membrane potential stimulates ADP import and ATP export by the mitochondrial ADP/ATP carrier due to its positively charged binding site.

Vasiliki Mavridou, Martin S King, Andre Bazzone et al.
1.00
Adenosine Triphosphate Adenosine Diphosphate Mitochondrial ADP, ATP Translocases Binding Sites Mitochondria

Myosin-binding protein-H: Not just filler.

David Y Barefield
1.00
Animals Humans Sarcomeres Muscle Proteins Carrier Proteins

Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Role of STAR and SCP2/SCPx in the Transport of...
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Cholestérol › Role of STAR and SCP2/SCPx in the Transport of...
questionsmedicales.fr › Métabolisme › Transport biologique › Role of STAR and SCP2/SCPx in the Transport of...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Role of STAR and SCP2/SCPx in the Transport of...