Antibacterial Porous Systems Based on Polylactide Loaded with Amikacin.
amikacin
drug delivery systems
poly(lactic acid)
porous matrices
tissue engineering
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
19 Oct 2022
19 Oct 2022
Historique:
received:
14
09
2022
revised:
14
10
2022
accepted:
16
10
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
29
10
2022
Statut:
epublish
Résumé
Three porous matrices based on poly(lactic acid) are proposed herein for the controlled release of amikacin. The materials were fabricated by the method of spraying a surface liquid. Description is given as to the possibility of employing a modifier, such as a silica nanocarrier, for prolonging the release of amikacin, in addition to using chitosan to improve the properties of the materials, e.g., stability and sorption capacity. Depending on their actual composition, the materials exhibited varied efficacy for drug loading, as follows: 25.4 ± 2.2 μg/mg (matrices with 0.05%
Identifiants
pubmed: 36296639
pii: molecules27207045
doi: 10.3390/molecules27207045
pmc: PMC9609933
pii:
doi:
Substances chimiques
Amikacin
84319SGC3C
poly(lactide)
459TN2L5F5
Chitosan
9012-76-4
Silicon Dioxide
7631-86-9
Delayed-Action Preparations
0
Anti-Bacterial Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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