Targeting the Platelet-Activating Factor Receptor (PAF-R): Antithrombotic and Anti-Atherosclerotic Nutrients.
antithrombotic activity
atherosclerosis
inflammation
platelet-activating factor
platelet-activating factor receptor
polar lipids
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
20 Oct 2022
20 Oct 2022
Historique:
received:
12
09
2022
revised:
17
10
2022
accepted:
18
10
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
29
10
2022
Statut:
epublish
Résumé
Platelet-activating factor (PAF) is a lipid mediator that interacts with its receptor (PAF-R) to carry out cell signalling. However, under certain conditions the binding of PAF to PAF-R leads to the activation of pro-inflammatory and prothrombotic pathways that have been implicated in the onset and development of atherosclerotic cardiovascular diseases (CVD) and inflammatory diseases. Over the past four decades, research has focused on the identification and development of PAF-R antagonists that target these inflammatory diseases. Research has also shown that dietary factors such as polar lipids, polyphenols, and other nutrient constituents may affect PAF metabolism and PAF-R function through various mechanisms. In this review we focus on the inhibition of PAF-R and how this may contribute to reducing cardiovascular disease risk. We conclude that further development of PAF-R inhibitors and human studies are required to investigate how modulation of the PAF-R may prevent the development of atherosclerotic cardiovascular disease and may lead to the development of novel therapeutics.
Identifiants
pubmed: 36297097
pii: nu14204414
doi: 10.3390/nu14204414
pmc: PMC9607086
pii:
doi:
Substances chimiques
Fibrinolytic Agents
0
Receptors, G-Protein-Coupled
0
Platelet Activating Factor
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Enterprise Ireland
ID : IP20210972
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
J Allergy Clin Immunol. 1997 May;99(5):640-7
pubmed: 9155831
Allergy. 2008 Apr;63 Suppl 87:5-28
pubmed: 18339040
Arch Med Res. 2015 Jul;46(5):328-38
pubmed: 26135634
Alzheimers Dement (N Y). 2019 Oct 04;5:524-532
pubmed: 31650009
Eur J Clin Nutr. 2022 Mar;76(3):350-359
pubmed: 34282294
Am J Obstet Gynecol. 1989 Dec;161(6 Pt 1):1714-7
pubmed: 2603931
Clin Ther. 2020 Oct;42(10):1850-1852
pubmed: 32883529
Clin Exp Pharmacol Physiol. 1990 Sep;17(9):645-51
pubmed: 2279352
Nature. 1979 Jun 28;279(5716):799-800
pubmed: 377104
Int Arch Allergy Immunol. 2004 May;134(1):17-28
pubmed: 15051936
Heliyon. 2017 Jan 09;3(1):e00227
pubmed: 28119955
Heart. 2003 Aug;89(8):897-900
pubmed: 12860868
Cancer Metastasis Rev. 2007 Dec;26(3-4):359-71
pubmed: 17721743
Biol Trace Elem Res. 2021 Dec;199(12):4564-4571
pubmed: 33527339
Biomolecules. 2019 Oct 24;9(11):
pubmed: 31653092
Physiol Rev. 2000 Oct;80(4):1669-99
pubmed: 11015622
Antioxidants (Basel). 2019 Oct 29;8(11):
pubmed: 31671743
Front Immunol. 2015 Mar 06;6:98
pubmed: 25798138
Blood. 1982 Mar;59(3):582-5
pubmed: 7037068
Crit Rev Clin Lab Sci. 2003 Dec;40(6):643-72
pubmed: 14708958
Neuroscience. 2018 May 1;377:105-113
pubmed: 29522856
Food Funct. 2019 Dec 11;10(12):8069-8080
pubmed: 31761914
J Comput Chem. 2004 Oct;25(13):1605-12
pubmed: 15264254
Orv Hetil. 2020 Aug;161(35):1488-1496
pubmed: 32822328
Foods. 2020 Mar 26;9(4):
pubmed: 32224958
Food Funct. 2020 Apr 30;11(4):2861-2885
pubmed: 32270798
Nutrients. 2018 May 12;10(5):
pubmed: 29757226
Blood Rev. 2021 Jan;45:100694
pubmed: 32340775
Hum Exp Toxicol. 2019 Apr;38(4):419-433
pubmed: 30537864
Int J Immunopathol Pharmacol. 2015 Dec;28(4):584-9
pubmed: 26486136
Bioresour Technol. 2006 Aug;97(12):1372-6
pubmed: 16112857
J Clin Invest. 1997 May 15;99(10):2358-64
pubmed: 9153277
Br J Nutr. 2015 Jan 14;113(1):1-15
pubmed: 25430608
BMJ. 1999 Dec 11;319(7224):1523-8
pubmed: 10591709
Circulation. 1996 Nov 15;94(10):2434-40
pubmed: 8921785
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1987;87(1):41-6
pubmed: 2885139
Nat Med. 2003 Jan;9(1):61-7
pubmed: 12483207
J Pharm Pharmacol. 1997 May;49(5):562-6
pubmed: 9178195
Reprod Domest Anim. 2008 Dec;43(6):647-55
pubmed: 18363604
Interv Cardiol Clin. 2017 Jan;6(1):1-12
pubmed: 27886814
Front Immunol. 2022 May 26;13:869591
pubmed: 35720377
J Thromb Haemost. 2007 Jul;5 Suppl 1:203-11
pubmed: 17635728
Nutrients. 2021 Jan 30;13(2):
pubmed: 33573169
Foods. 2019 Sep 15;8(9):
pubmed: 31540159
J Steroid Biochem Mol Biol. 2019 Mar;187:152-159
pubmed: 30476590
Arch Pharm Res. 2014 Aug;37(8):1069-78
pubmed: 24234914
J Biol Chem. 1979 Oct 10;254(19):9355-8
pubmed: 489536
Adv Nutr. 2019 Jan 1;10(1):148-164
pubmed: 30721934
Arch Biochem Biophys. 1988 Feb 1;260(2):841-6
pubmed: 3341767
Eur J Obstet Gynecol Reprod Biol. 1979 Apr;9(2):75-80
pubmed: 264086
J Biochem. 2002 Jun;131(6):773-9
pubmed: 12038971
Pol J Vet Sci. 2016;19(1):147-58
pubmed: 27096799
Metallomics. 2016 Jan;8(1):91-100
pubmed: 26434726
Nutr Metab Cardiovasc Dis. 2006 Apr;16(3):174-85
pubmed: 16580585
J Agric Food Chem. 2002 Feb 27;50(5):1150-60
pubmed: 11853496
Nihon Sanka Fujinka Gakkai Zasshi. 1991 May;43(5):523-8
pubmed: 2056228
J Exp Med. 2002 Oct 7;196(7):887-96
pubmed: 12370251
Clin Biochem. 2018 Sep;60:1-10
pubmed: 30142319
Sci Rep. 2019 Jun 6;9(1):8333
pubmed: 31171812
Nutrients. 2020 Jul 15;12(7):
pubmed: 32679784
Prog Lipid Res. 2000 Jan;39(1):41-82
pubmed: 10729607
Public Health Nutr. 2006 Feb;9(1A):118-23
pubmed: 16512958
Int Arch Allergy Immunol. 2012;158 Suppl 1:96-102
pubmed: 22627375
Phytomedicine. 2008 Apr;15(4):306-9
pubmed: 17913483
Arch Biochem Biophys. 1989 Aug 1;272(2):466-75
pubmed: 2502069
Front Nutr. 2020 Sep 25;7:583080
pubmed: 33102511
AIDS Rev. 2015 Oct-Dec;17(4):191-201
pubmed: 26616844
Metabolism. 2018 Jun;83:102-119
pubmed: 29408458
Food Res Int. 2021 Jan;139:109976
pubmed: 33509521
Transfus Med Hemother. 2020 Apr;47(2):110-118
pubmed: 32355470
Nutr Rev. 2022 May 9;80(6):1371-1391
pubmed: 34651191
Sci Rep. 2017 Sep 28;7(1):12373
pubmed: 28959007
Allergy. 2015 Jan;70 Suppl 100:1-24
pubmed: 25491409
Nutrients. 2015 Sep 15;7(9):7806-20
pubmed: 26389947
Biophys Chem. 2001 Mar 15;90(1):57-74
pubmed: 11321675
Circulation. 2011 Jun 21;123(24):2870-91
pubmed: 21690503
Br J Nutr. 2019 May;121(9):982-991
pubmed: 30940217
J Nutr. 2004 Jan;134(1):257S-261S
pubmed: 14704330
J Agric Food Chem. 2007 Feb 21;55(4):1280-8
pubmed: 17256959
Circ Res. 2020 Jan 3;126(1):75-90
pubmed: 31829100
Nutrients. 2022 May 18;14(10):
pubmed: 35631239
Circ Res. 2022 Sep 2;131(6):492-506
pubmed: 35950704
Nutrients. 2019 Nov 19;11(11):
pubmed: 31752257
J Lipid Res. 1985 Sep;26(9):1015-35
pubmed: 3906008
Indian J Clin Biochem. 2013 Oct;28(4):314-28
pubmed: 24426232
J Physiol Pharmacol. 2005 Dec;56(4):627-35
pubmed: 16391419
J Agric Food Chem. 2001 Nov;49(11):5186-93
pubmed: 11714301
FASEB J. 2002 Jun;16(8):908-10
pubmed: 12039876
J Reprod Fertil. 1993 Jul;98(2):541-8
pubmed: 8410823
Nature. 2021 Apr;592(7855):524-533
pubmed: 33883728
Lupus. 2018 Dec;27(14):2181-2189
pubmed: 30282560
Anim Sci J. 2013 Mar;84(3):264-71
pubmed: 23480708
Mar Drugs. 2021 Jan 10;19(1):
pubmed: 33435162
J Am Coll Nutr. 2006 Aug;25(4):285-91
pubmed: 16943449
Molecules. 2019 Dec 03;24(23):
pubmed: 31816871
Vascul Pharmacol. 2019 Sep;120:106564
pubmed: 31176855
Annu Rev Nutr. 2005;25:151-74
pubmed: 16011463
Adv Exp Med Biol. 1996;416:59-63
pubmed: 9131127
Mar Drugs. 2019 Jan 18;17(1):
pubmed: 30669323
Bioorg Med Chem Lett. 2007 Dec 15;17(24):6720-2
pubmed: 17964782
Biochem Biophys Res Commun. 1994 Dec 15;205(2):1137-42
pubmed: 7802642
Biochem Pharmacol. 1999 Oct 1;58(7):1167-72
pubmed: 10484074
Prostaglandins Other Lipid Mediat. 2017 May;130:23-29
pubmed: 28323197
Adv Food Nutr Res. 2019;87:187-254
pubmed: 30678815
Thromb Haemost. 1996 Apr;75(4):630-4
pubmed: 8743191
Molecules. 2017 Nov 14;22(11):
pubmed: 29135918
J Agric Food Chem. 2000 Dec;48(12):6372-9
pubmed: 11312810
Clin Interv Aging. 2007;2(1):109-15
pubmed: 18044083
Antioxid Redox Signal. 2001 Dec;3(6):1147-52
pubmed: 11813988
Int Arch Allergy Immunol. 2004 Jun;134 Suppl 1:37-43
pubmed: 15166482
FASEB J. 1992 Mar;6(6):2296-301
pubmed: 1312046
Proc Natl Acad Sci U S A. 1996 Jan 23;93(2):774-9
pubmed: 8570633
Acta Med Scand. 1972 Jul-Aug;192(1-2):85-94
pubmed: 5052396
Cells. 2022 Mar 17;11(6):
pubmed: 35326465
J Med Food. 2010 Oct;13(5):1069-74
pubmed: 20828311
Front Immunol. 2018 Sep 28;9:2220
pubmed: 30323811
Platelets. 2015;26(3):224-9
pubmed: 24749953
Biochimie. 2010 Jun;92(6):692-7
pubmed: 20167241
Lipids. 1989 Mar;24(3):236-9
pubmed: 2761359
Immunology. 2000 Feb;99(2):314-9
pubmed: 10692052
Prostaglandins Other Lipid Mediat. 2008 Mar;85(3-4):125-33
pubmed: 18248752
Nutrients. 2021 Feb 26;13(3):
pubmed: 33652653
Phytomedicine. 2007 Dec;14(12):853-5
pubmed: 17689230
Annu Rev Biochem. 2000;69:419-45
pubmed: 10966465
Am J Hematol. 1991 Nov;38(3):161-5
pubmed: 1951315
PLoS One. 2013 Oct 09;8(10):e75664
pubmed: 24130731
Andrologia. 2020 Jun;52(5):e13565
pubmed: 32187723
Am J Clin Nutr. 2010 Jun;91(6):1634-41
pubmed: 20427734
Vascul Pharmacol. 2014 Mar;60(3):120-6
pubmed: 24534482
Am J Respir Crit Care Med. 1995 May;151(5):1331-5
pubmed: 7735582
Int J Artif Organs. 2013 Feb;36(2):87-96
pubmed: 23335378
Food Chem. 2020 Dec 1;332:127384
pubmed: 32615384
Phytomedicine. 2005 Jan;12(1-2):88-92
pubmed: 15693713
Biochim Biophys Acta. 2012 Jul;1824(7):907-12
pubmed: 22579962
Immunology. 2008 Jul;124(3):295-303
pubmed: 18217950
Circulation. 2002 Mar 5;105(9):1135-43
pubmed: 11877368
J Agric Food Chem. 2012 Sep 5;60(35):8731-7
pubmed: 22881190
Prostaglandins Leukot Essent Fatty Acids. 1994 Jan;50(1):1-28
pubmed: 8146205
Int J Mol Sci. 2012 Nov 21;13(11):15401-19
pubmed: 23203133
Am J Med. 2015 Mar;128(3):229-38
pubmed: 25447615
Pharmacol Res. 2022 Jan;175:106001
pubmed: 34826602
J Agric Food Chem. 2002 Oct 9;50(21):6227-32
pubmed: 12358507
J Ethnopharmacol. 2014 Feb 27;152(1):151-5
pubmed: 24412551
Bioinorg Chem Appl. 2017;2017:6947034
pubmed: 28458618
Eur J Nutr. 2017 Jun;56(4):1485-1492
pubmed: 26936842
J Exp Med. 2019 Dec 2;216(12):2838-2853
pubmed: 31558613
Lancet. 1992 Jun 20;339(8808):1523-6
pubmed: 1351198
J Allergy Clin Immunol. 2010 May;125(5):1137-1145.e6
pubmed: 20392487
Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E19-27
pubmed: 19116372
Biochem J. 1993 Jun 15;292 ( Pt 3):617-29
pubmed: 8391253
Biochim Biophys Acta. 1989 Nov 28;1006(2):151-8
pubmed: 2512981
Phytother Res. 2015 Mar;29(3):450-8
pubmed: 25572959
J Am Coll Cardiol. 2018 Aug 21;72(8):914-926
pubmed: 30115231
Int J Mol Sci. 2022 Mar 20;23(6):
pubmed: 35328769
Biofactors. 2022 Aug 27;:
pubmed: 36029481
J Clin Med. 2019 Aug 29;8(9):
pubmed: 31470575
J Immunol. 1980 Feb;124(2):676-84
pubmed: 7356708
Methods Mol Biol. 2022;2419:333-347
pubmed: 35237975
Crit Care Med. 2002 May;30(5 Suppl):S294-301
pubmed: 12004251
Food Funct. 2015 Aug;6(8):2679-83
pubmed: 26137920
BMJ. 2000 Nov 4;321(7269):1133-5
pubmed: 11061738
Circulation. 2004 Jun 15;109(23 Suppl 1):III27-32
pubmed: 15198963
J Exp Med. 1972 Dec 1;136(6):1356-77
pubmed: 4118412
Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14138-43
pubmed: 19666557