DNA Prime and Recombinant Protein Boost Vaccination Confers Chickens with Enhanced Protection against Chicken Infectious Anemia Virus.
Animals
Chicken anemia virus
/ genetics
Chickens
Vaccines, DNA
Vaccines, Attenuated
Poultry Diseases
Interleukin-4
Interleukin-2
Escherichia coli
/ genetics
Viral Vaccines
/ genetics
Vaccination
/ veterinary
Circoviridae Infections
/ prevention & control
Recombinant Proteins
/ genetics
Vaccines, Subunit
DNA
Antibodies, Viral
DNA prime/protein boost
antibody titer
cellular immunity
chicken infectious anemia virus
protective efficacy
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
24 09 2022
24 09 2022
Historique:
received:
22
08
2022
revised:
19
09
2022
accepted:
22
09
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
29
10
2022
Statut:
epublish
Résumé
Chicken infectious anemia (CIA) is an immunosuppressive disease caused by chicken infectious anemia virus (CIAV) that poses a great threat to the poultry industry worldwide. At present, vaccination is an important way to prevent and control CIA. Apart from a CIAV-attenuated vaccine used in clinical practice, the research and development of a genetically engineered vaccine has good prospects. However, it is difficult to induce a strong protective effect with a single subunit vaccine or DNA vaccine. Therefore, the goal of this study is to develop and evaluate a DNA prime/protein boost vaccine strategy for defense against CIAV infection and spread. In this study, the recombinant proteins of CIAV VP1 and VP2 were prepared using an
Identifiants
pubmed: 36298670
pii: v14102115
doi: 10.3390/v14102115
pmc: PMC9612391
pii:
doi:
Substances chimiques
Vaccines, DNA
0
Vaccines, Attenuated
0
Interleukin-4
207137-56-2
Interleukin-2
0
Viral Vaccines
0
Recombinant Proteins
0
Vaccines, Subunit
0
DNA
9007-49-2
Antibodies, Viral
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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