Pin-Pointing the Key Hubs in the IFN-γ Pathway Responding to SARS-CoV-2 Infection.
COVID-19
IFN-γ
ISGs
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
30 09 2022
30 09 2022
Historique:
received:
27
07
2022
revised:
30
08
2022
accepted:
28
09
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
29
10
2022
Statut:
epublish
Résumé
Interferon gamma (IFN-γ) may be potential adjuvant immunotherapy for COVID-19 patients. In this work, we assessed gene expression profiles associated with the IFN-γ pathway in response to SARS-CoV-2 infection. Employing a case-control study from SARS-CoV-2-positive and -negative patients, we identified IFN-γ-associated pathways to be enriched in positive patients. Bioinformatics analyses showed upregulation of
Identifiants
pubmed: 36298734
pii: v14102180
doi: 10.3390/v14102180
pmc: PMC9610092
pii:
doi:
Substances chimiques
Interferon-gamma
82115-62-6
RNA, Double-Stranded
0
Map2k6 protein, mouse
EC 2.7.12.2
MAP Kinase Kinase 6
EC 2.7.12.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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