Epitope Mapping of an Anti-Mouse CXCR6 Monoclonal Antibody (Cx
2 × Ala scanning
enzyme-linked immunosorbent assay
epitope mapping
monoclonal antibody
mouse CXCR6
Journal
Monoclonal antibodies in immunodiagnosis and immunotherapy
ISSN: 2167-9436
Titre abrégé: Monoclon Antib Immunodiagn Immunother
Pays: United States
ID NLM: 101590955
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
pubmed:
28
10
2022
medline:
2
11
2022
entrez:
27
10
2022
Statut:
ppublish
Résumé
The CXC chemokine receptor 6 (CXCR6) is a member of the G protein-coupled receptor family that is highly expressed in helper T type 1 cells, cytotoxic T lymphocytes (CTLs), and natural killer cells. CXCR6 plays critical roles in local expansion of effector-like CTLs in tumor microenvironment to potentiate the antitumor response. Therefore, the development of anti-CXCR6 monoclonal antibodies (mAbs) is essential to evaluate the immune microenvironment of tumors. Using N-terminal peptide immunization, we previously developed an anti-mouse CXCR6 (mCXCR6) mAb, Cx
Identifiants
pubmed: 36301196
doi: 10.1089/mab.2022.0019
doi:
Substances chimiques
Receptors, CXCR6
0
Alanine
OF5P57N2ZX
Antibodies, Monoclonal
0
Epitopes
0
Peptides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM