Ablation of CD8
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
27 10 2022
27 10 2022
Historique:
received:
25
01
2022
accepted:
17
10
2022
entrez:
27
10
2022
pubmed:
28
10
2022
medline:
1
11
2022
Statut:
epublish
Résumé
The emergence of the SARS-CoV-2 Omicron variant has raised concerns of escape from vaccine-induced immunity. A number of studies have demonstrated a reduction in antibody-mediated neutralization of the Omicron variant in vaccinated individuals. Preliminary observations have suggested that T cells are less likely to be affected by changes in Omicron. However, the complexity of human leukocyte antigen genetics and its impact upon immunodominant T cell epitope selection suggests that the maintenance of T cell immunity may not be universal. In this study, we describe the impact that changes in Omicron BA.1, BA.2 and BA.3 have on recognition by spike-specific T cells. These T cells constitute the immunodominant CD8
Identifiants
pubmed: 36302758
doi: 10.1038/s41467-022-34180-1
pii: 10.1038/s41467-022-34180-1
pmc: PMC9607807
doi:
Substances chimiques
Immunodominant Epitopes
0
Antibodies, Viral
0
Antibodies, Neutralizing
0
Spike Glycoprotein, Coronavirus
0
spike protein, SARS-CoV-2
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6387Informations de copyright
© 2022. The Author(s).
Références
Cell. 2022 Feb 3;185(3):447-456.e11
pubmed: 35026151
Nat Med. 2021 Jul;27(7):1280-1289
pubmed: 34017137
Acta Crystallogr D Biol Crystallogr. 2010 Apr;66(Pt 4):486-501
pubmed: 20383002
J Clin Invest. 2021 Mar 1;131(5):
pubmed: 33427749
mBio. 2022 Apr 26;13(2):e0361721
pubmed: 35229637
Int J Mol Sci. 2020 Dec 23;22(1):
pubmed: 33374673
Nat Med. 2022 Mar;28(3):472-476
pubmed: 35042228
Sci Immunol. 2021 Apr 14;6(58):
pubmed: 33853928
Acta Crystallogr D Biol Crystallogr. 1994 Sep 1;50(Pt 5):760-3
pubmed: 15299374
Immunity. 2021 May 11;54(5):1055-1065.e5
pubmed: 33945786
iScience. 2021 Feb 19;24(2):102096
pubmed: 33521593
J Synchrotron Radiat. 2018 May 1;25(Pt 3):885-891
pubmed: 29714201
Lancet. 2022 Jan 15;399(10321):234-236
pubmed: 34942101
Ann Neurol. 2022 Jan;91(1):89-100
pubmed: 34687063
Cell Rep. 2021 Sep 14;36(11):109708
pubmed: 34506741
Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):125-32
pubmed: 20124692
J Appl Crystallogr. 2007 Aug 1;40(Pt 4):658-674
pubmed: 19461840
Cell Rep Med. 2021 Feb 16;2(2):100204
pubmed: 33521695