Common variability in oestrogen-related genes and pancreatic ductal adenocarcinoma risk in women.

Female Humans Adenocarcinoma / pathology Carcinoma, Pancreatic Ductal / pathology Estrogens / genetics Pancreatic Neoplasms / epidemiology Pregnenolone Pancreatic Neoplasms

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
27 10 2022
Historique:
received: 20 07 2022
accepted: 21 10 2022
entrez: 27 10 2022
pubmed: 28 10 2022
medline: 1 11 2022
Statut: epublish

Résumé

The incidence of pancreatic ductal adenocarcinoma (PDAC) is different among males and females. This disparity cannot be fully explained by the difference in terms of exposure to known risk factors; therefore, the lower incidence in women could be attributed to sex-specific hormones. A two-phase association study was conducted in 12,387 female subjects (5436 PDAC cases and 6951 controls) to assess the effect on risk of developing PDAC of single nucleotide polymorphisms (SNPs) in 208 genes involved in oestrogen and pregnenolone biosynthesis and oestrogen-mediated signalling. In the discovery phase 14 polymorphisms showed a statistically significant association (P < 0.05). In the replication none of the findings were validated. In addition, a gene-based analysis was performed on the 208 selected genes. Four genes (NR5A2, MED1, NCOA2 and RUNX1) were associated with PDAC risk, but only NR5A2 showed an association (P = 4.08 × 10

Identifiants

DOI: 10.1038/s41598-022-22973-9 PMID: 36302831 PMC: PMC9613634
pubmed: 36302831
doi: 10.1038/s41598-022-22973-9
pii: 10.1038/s41598-022-22973-9
pmc: PMC9613634
doi:

Substances chimiques

Estrogens 0
Pregnenolone 73R90F7MQ8

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

18100

Subventions

Organisme : European Regional Development Fund
ID : IMTS: 313011V446
Organisme : Operational Programme Integrated Infrastructure
ID : IMTS: 313011V446
Organisme : Cancer Research UK
ID : C864/A14136
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N003284/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0401527
Pays : United Kingdom
Organisme : AZV
ID : NU21-07-00247
Organisme : Czech Health Research Council
ID : NV19-03-00097
Organisme : Cancer Research UK
ID : 14136
Pays : United Kingdom
Organisme : National operation Programm: National Institute for cancer research
ID : LX22NPO05102
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : IG 2021-ID. 26201 project
Organisme : Medical Research Council
ID : G1000143
Pays : United Kingdom

Informations de copyright

© 2022. The Author(s).

Références

Rahib, L. et al. Projecting cancer incidence and deaths to 2030: The unexpected burden of thyroid, liver, and pancreas cancers in the united states. Cancer Res. 74, 2913–2921 (2014).
pubmed: 24840647 doi: 10.1158/0008-5472.CAN-14-0155
Ferlay, J. et al. Cancer statistics for the year 2020: An overview. Int. J. Cancer 149, 778–789 (2021).
doi: 10.1002/ijc.33588
Sung, H. et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA. Cancer J. Clin. 71, 209–249 (2021).
pubmed: 33538338 doi: 10.3322/caac.21660
Pourshams, A. et al. The global, regional, and national burden of pancreatic cancer and its attributable risk factors in 195 countries and territories, 1990–2017: A systematic analysis for the Global Burden of Disease Study 2017. Lancet. Gastroenterol. Hepatol. 4, 934–947 (2019).
doi: 10.1016/S2468-1253(19)30347-4
Sumi, C., Brinck-Johnsen, T. & Longnecker, D. S. Inhibition of a transplantable pancreatic carcinoma by castration and estradiol administration in rats. Cancer Res. 49, 6687–6692 (1989).
pubmed: 2479469
Santen, R. J. et al. Postmenopausal hormone therapy: An endocrine society scientific statement. J. Clin. Endocrinol. Metab. 95, s1–s66 (2010).
pubmed: 20566620 pmcid: 6287288 doi: 10.1210/jc.2009-2509
Wahi, M. M., Shah, N., Schrock, C. E., Rosemurgy, A. S. & Goldin, S. B. Reproductive factors and risk of pancreatic cancer in women: A review of the literature. Ann. Epidemiol. 19, 103–111 (2009).
pubmed: 19185803 doi: 10.1016/j.annepidem.2008.11.003
Michels, K. A., Brinton, L. A., Pfeiffer, R. M. & Trabert, B. Oral contraceptive use and risks of cancer in the NIH-AARP diet and health study. Am. J. Epidemiol. 187, 1630 (2018).
pubmed: 29394309 pmcid: 6487535 doi: 10.1093/aje/kwx388
Teng, Y. et al. Female reproductive factors, exogenous hormone use, and pancreatic cancer risk: The Japan Public Health Center-based prospective study. Eur. J. Cancer Prev. 26, 378–384 (2017).
pubmed: 28368947 doi: 10.1097/CEJ.0000000000000358
Andersson, G., Borgquist, S. & Jirström, K. Hormonal factors and pancreatic cancer risk in women: The Malmö Diet and Cancer Study. Int. J. Cancer 143, 52–62 (2018).
pubmed: 29424426 pmcid: 5969235 doi: 10.1002/ijc.31302
Sadr-Azodi, O., Konings, P. & Brusselaers, N. Menopausal hormone therapy and pancreatic cancer risk in women: A population-based matched cohort study. United Eur. Gastroenterol. J. 5, 1123–1128 (2017).
doi: 10.1177/2050640617702060
Butt, S. A. et al. Hormonal contraceptive use and risk of pancreatic cancer—A cohort study among premenopausal women. PLoS ONE 13, e0206358 (2018).
pubmed: 30376560 pmcid: 6207333 doi: 10.1371/journal.pone.0206358
Kabat, G. C., Kamensky, V. & Rohan, T. E. Reproductive factors, exogenous hormone use, and risk of pancreatic cancer in postmenopausal women. Cancer Epidemiol. 49, 1–7 (2017).
pubmed: 28521283 doi: 10.1016/j.canep.2017.05.002
Tang, B. et al. Relationship between female hormonal and menstrual factors and pancreatic cancer: A meta-analysis of observational studies. Medicine Baltimore. 94, e177 (2015).
pubmed: 25700305 pmcid: 4554173 doi: 10.1097/MD.0000000000000177
Amundadottir, L. et al. Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat. Genet. 41, 986–990 (2009).
pubmed: 19648918 pmcid: 2839871 doi: 10.1038/ng.429
Petersen, G. M. et al. A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat. Genet. 5, 224–228 (2010).
doi: 10.1038/ng.522
Yang, W. et al. Three novel genetic variants in NRF2 signaling pathway genes are associated with pancreatic cancer risk. Cancer Sci. 20, 32. https://doi.org/10.1111/cas.14017 (2019).
doi: 10.1111/cas.14017
Gentiluomo, M., Peduzzi, G., Lu, Y., Campa, D. & Canzian, F. Genetic polymorphisms in inflammatory genes and pancreatic cancer risk: A two-phase study on more than 14 000 individuals. Mutagenesis 34, 395–401 (2019).
pubmed: 31748817
Campa, D. et al. Genome-wide association study identifies an early onset pancreatic cancer risk locus. Int. J. Cancer 147, 2065–2074 (2020).
pubmed: 32270874 doi: 10.1002/ijc.33004
Gentiluomo, M. et al. Germline genetic variability in pancreatic cancer risk and prognosis. Semin. Cancer Biol. https://doi.org/10.1016/j.semcancer.2020.08.003 (2020).
doi: 10.1016/j.semcancer.2020.08.003 pubmed: 32818625
Corradi, C. et al. Genome-wide scan of long noncoding RNA single nucleotide polymorphisms and pancreatic cancer susceptibility. Int. J. Cancer 148, 2779–2788 (2021).
pubmed: 33534179 doi: 10.1002/ijc.33475
Rizzato, C. et al. ABO blood groups and pancreatic cancer risk and survival: Results from the PANcreatic Disease ReseArch (PANDoRA) consortium. Oncol. Rep. 29, 1637–1644 (2013).
pubmed: 23403949 doi: 10.3892/or.2013.2285
Wolpin, B. M. et al. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. Nat. Genet. 46, 994–1000 (2014).
pubmed: 25086665 pmcid: 4191666 doi: 10.1038/ng.3052
Childs, E. J. et al. Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer. Nat. Genet. 47, 911–916 (2015).
pubmed: 26098869 pmcid: 4520746 doi: 10.1038/ng.3341
Campa, D. et al. TERT gene harbors multiple variants associated with pancreatic cancer susceptibility. Int. J. Cancer 137, 2175–2183 (2015).
pubmed: 25940397 pmcid: 4548797 doi: 10.1002/ijc.29590
Campa, D. et al. Functional single nucleotide polymorphisms within the cyclin-dependent kinase inhibitor 2A/2B region affect pancreatic cancer risk. Oncotarget 7, 57011–57020 (2016).
pubmed: 27486979 pmcid: 5302969 doi: 10.18632/oncotarget.10935
Zhang, M. et al. Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21. Oncotarget 7, 35 (2016).
Klein, A. P. et al. Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer. Nat. Commun. 9, (2018).
Xu, X. et al. Genetic variants in the liver kinase B1-AMP-activated protein kinase pathway genes and pancreatic cancer risk. Mol. Carcinog. 58, 1338–1348 (2019).
pubmed: 30997723 pmcid: 6602843 doi: 10.1002/mc.23018
Larsson, S. C. et al. Serum estradiol and 20 Site-specific cancers in women: Mendelian randomization study. J. Clin. Endocrinol. Metab. 107, e467 (2022).
pubmed: 34601599 doi: 10.1210/clinem/dgab713
Johnson, N. et al. CYP3A7*1C allele: Linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers. Br. J. Cancer 124, 842 (2021).
pubmed: 33495599 pmcid: 7884683 doi: 10.1038/s41416-020-01185-w
Cote, M. L. et al. Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women. Carcinogenesis 30, 626 (2009).
pubmed: 19174490 pmcid: 2664455 doi: 10.1093/carcin/bgp033
Tang, L. et al. Associations between polymorphisms in genes related to estrogen metabolism and function and prostate cancer risk: Results from the Prostate Cancer Prevention Trial. Carcinogenesis 39, 125 (2018).
pubmed: 29228205 doi: 10.1093/carcin/bgx144
Quan, L. et al. Variants in estrogen-related genes and breast cancer risk in European and African American women. Endocr. Relat. Cancer 21, 853 (2014).
pubmed: 25228414 pmcid: 4214251 doi: 10.1530/ERC-14-0250
Freedman, N. D. et al. Polymorphisms in estrogen- and androgen-metabolizing genes and the risk of gastric cancer. Carcinogenesis 30, 71 (2009).
pubmed: 19015200 doi: 10.1093/carcin/bgn258
Galeotti, A. A. et al. Polygenic and multifactorial scores for pancreatic ductal adenocarcinoma risk prediction. J. Med. Genet. 58, 369–377 (2021).
pubmed: 32591343 doi: 10.1136/jmedgenet-2020-106961
Zhang, Y., Coogan, P. F., Palmer, J. R., Strom, B. L. & Rosenberg, L. A case–control study of reproductive factors, female hormone use, and risk of pancreatic cancer. Cancer Causes Control 21, 473 (2010).
pubmed: 19941157 doi: 10.1007/s10552-009-9478-9
Lee, E. et al. Reproductive factors, exogenous hormones, and pancreatic cancer risk in the CTS. Am. J. Epidemiol. 178, 1403–1413 (2013).
pubmed: 24008905 pmcid: 3813312 doi: 10.1093/aje/kwt154
Chen, K. Y. et al. Estrogen receptor gene polymorphisms and lung adenocarcinoma risk in never-smoking women. J. Thorac. Oncol. 10, 1413–1420 (2015).
pubmed: 26301798 doi: 10.1097/JTO.0000000000000646
Lee, Y. Liver receptor homolog-1, an emerging metabolic modulator. Front. Biosci. 5950 (2008).
Chen, Q. et al. Association between NR5A2 and the risk of pancreatic cancer, especially among Caucasians: A meta-analysis of case–control studies. Onco. Targets. Ther. 11, 2709–2723 (2018).
pubmed: 29785120 pmcid: 5953269 doi: 10.2147/OTT.S157759
von Figura, G., Morris, J. P., Wright, C. V. E. & Hebrok, M. Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation. Gut 63, 656–664 (2014).
doi: 10.1136/gutjnl-2012-304287
Campa, D. et al. Genetic variability of the forkhead box O3 and prostate cancer risk in the European Prospective Investigation on Cancer. Oncol. Rep. 26, 979–986 (2011).
pubmed: 21725602
Noordam, R. et al. Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration. Nat. Commun. 10, (2019).
Liu, S. et al. Integration of transcriptome and cistrome analysis identifies RUNX1-target genes involved in pancreatic cancer proliferation. Genomics 112, 5343–5355 (2020).
pubmed: 33189780 doi: 10.1016/j.ygeno.2020.11.010
Rohira, A. D. & Lonard, D. M. Steroid receptor coactivators present a unique opportunity for drug development in hormone-dependent cancers. Biochem. Pharmacol. 140, 1–7 (2017).
pubmed: 28390937 doi: 10.1016/j.bcp.2017.04.005
Park, S. K. et al. Polymorphisms of estrogen receptors and risk of biliary tract cancers and gallstones: A population-based study in Shanghai, China. Carcinogenesis 31, 842–846 (2010).
pubmed: 20172949 pmcid: 2864412 doi: 10.1093/carcin/bgq038
Lin, J. et al. Genetic variation in sex-steroid receptors and synthesizing enzymes and colorectal cancer risk in women. Cancer Causes Control 21, 897–908 (2010).
pubmed: 20148360 pmcid: 2873149 doi: 10.1007/s10552-010-9518-5
Gillespie, M. et al. The reactome pathway knowledgebase 2022. Nucleic Acids Res. 50, D687–D692 (2022).
pubmed: 34788843 doi: 10.1093/nar/gkab1028
Petersen, G. M. et al. A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat. Genet. 42, 224–228 (2010).
pubmed: 20101243 pmcid: 2853179 doi: 10.1038/ng.522
Chang, C. C. et al. Second-generation PLINK: Rising to the challenge of larger and richer datasets. Gigascience 4, 1–16 (2015).
doi: 10.1186/s13742-015-0047-8
Campa, D. et al. Genetic susceptibility to pancreatic cancer and its functional characterisation: The PANcreatic Disease ReseArch (PANDoRA) consortium. Dig. Liver Dis. 45, 95–99 (2013).
pubmed: 23206934 doi: 10.1016/j.dld.2012.09.014
Riboli, E. et al. European Prospective Investigation into Cancer and Nutrition (EPIC): Study populations and data collection. Public Health Nutr. 5, 1113–1124 (2002).
pubmed: 12639222 doi: 10.1079/PHN2002394
Löw, M., Stegmaier, C., Ziegler, H., Rothenbacher, D. & Brenner, H. Epidemiologische studie zu chancen der verhütung, früherkennung und optimierten therapie chronischer erkrankungen in der älteren bevölkerung (ESTHER-studie). Dtsch. Medizinische Wochenschrift 129, 2643–2647 (2004).
doi: 10.1055/s-2004-836089
de Leeuw, C. A., Mooij, J. M., Heskes, T. & Posthuma, D. MAGMA: Generalized gene-set analysis of GWAS data. PLoS Comput. Biol. 11, e1004219 (2015).
pubmed: 25885710 pmcid: 4401657 doi: 10.1371/journal.pcbi.1004219

Auteurs

Giulia Peduzzi (G)

Department of Biology, University of Pisa, 56126, Pisa, Italy.

Livia Archibugi (L)

Digestive and Liver Disease Unit, Sant'Andrea Hospital, Rome, Italy.
Pancreato-Biliary Endoscopy and Endoscopic Ultrasound, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute IRCCS, Milan, Italy.

Verena Katzke (V)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Manuel Gentiluomo (M)

Department of Biology, University of Pisa, 56126, Pisa, Italy.

Gabriele Capurso (G)

Digestive and Liver Disease Unit, Sant'Andrea Hospital, Rome, Italy.
Pancreato-Biliary Endoscopy and Endoscopic Ultrasound, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute IRCCS, Milan, Italy.

Anna Caterina Milanetto (AC)

Department DISCOG, University of Padova, Padua, Italy.

Maria Gazouli (M)

Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Mara Goetz (M)

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany.

Hermann Brenner (H)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

Roel C H Vermeulen (RCH)

University of Utrecht, Utrecht, The Netherlands.

Renata Talar-Wojnarowska (R)

Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland.

Giuseppe Vanella (G)

Digestive and Liver Disease Unit, Sant'Andrea Hospital, Rome, Italy.
Pancreato-Biliary Endoscopy and Endoscopic Ultrasound, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute IRCCS, Milan, Italy.

Francesca Tavano (F)

Division of Gastroenterology and Research Laboratory, Fondazione IRCCS "Casa Sollievo Della Sofferenza" Hospital, San Giovanni Rotondo, Italy.

Maurizio Lucchesi (M)

Oncology of Massa Carrara, Oncological Department, Azienda USL Toscana Nord Ovest, Carrara, Italy.

Beatrice Mohelnikova-Duchonova (B)

Department of Oncology, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic.

Xuechen Chen (X)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany.

Vytautas Kiudelis (V)

Gastroenterology Department and Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.

Péter Hegyi (P)

Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary.
Centre for Translational Medicine, Semmelweis University, Budapest, Hungary.
Division of Pancreatic Diseases, Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
János Szentágothai Research Center, University of Pécs, Pécs, Hungary.

Martin Oliverius (M)

Surgery Clinic Third Faculty of Medicine, Charles University, Prague, Czech Republic.

Hannah Stocker (H)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Network Aging Research (NAR), Heidelberg University, Heidelberg, Germany.

Caterina Stornello (C)

Digestive and Liver Disease Unit, Sant'Andrea Hospital, Rome, Italy.
Pancreato-Biliary Endoscopy and Endoscopic Ultrasound, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute IRCCS, Milan, Italy.

Ludmila Vodickova (L)

Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic.
First Faculty of Medicine, Institute of Biology and Medical Genetics, Charles University, Prague, Czech Republic.
Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.

Pavel Souček (P)

Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.

John P Neoptolemos (JP)

Department of General Surgery, University of Heidelberg, Heidelberg, Germany.

Sabrina Gloria Giulia Testoni (SGG)

Pancreato-Biliary Endoscopy and Endoscopic Ultrasound, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute IRCCS, Milan, Italy.

Luca Morelli (L)

General Surgery, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.

Rita T Lawlor (RT)

ARC-NET, Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona, Italy.

Daniela Basso (D)

Department DIMED-Laboratory Medicine, University of Padova, Padua, Italy.

Jakob R Izbicki (JR)

Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany.

Stefano Ermini (S)

Blood Transfusion Service, Azienda Ospedaliero-Universitaria Meyer, Florence, Italy.

Juozas Kupcinskas (J)

Gastroenterology Department and Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.

Raffaele Pezzilli (R)

Potenza Medical County Association, Potenza, Italy.

Ugo Boggi (U)

Division of General and Transplant Surgery, Pisa University Hospital, Pisa, Italy.

Hanneke W M van Laarhoven (HWM)

Department of Medical Oncology, Amsterdam UMC Location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.
Cancer Center Amsterdam, Imaging and Biomarkers, Amsterdam, The Netherlands.

Andrea Szentesi (A)

Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary.
János Szentágothai Research Center, University of Pécs, Pécs, Hungary.
Centre for Translational Medicine, Department of Medicine, University of Szeged, Szeged, Hungary.

Bálint Erőss (B)

Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary.
Division of Pancreatic Diseases, Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
Center for Translational Medicine, Semmelweis University, Budapest, Hungary.

Giovanni Capretti (G)

Department of Biomedical Sciences, Humanitas University, Milan, Italy.
Pancreatic Surgery Unit, IRCCS Humanitas Research Hospital, Milan, Italy.

Ben Schöttker (B)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Jurgita Skieceviciene (J)

Gastroenterology Department and Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.

Mateus Nóbrega Aoki (MN)

Laboratory for Applied Science and Technology in Health, Carlos Chagas Institute, Oswaldo Cruz Foundation (Fiocruz), Curitiba, Brazil.

Casper H J van Eijck (CHJ)

Department of Surgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

Giulia Martina Cavestro (GM)

Gastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Federico Canzian (F)

Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Daniele Campa (D)

Department of Biology, University of Pisa, 56126, Pisa, Italy. daniele.campa@unipi.it.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Common variability in oestrogen-related genes...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Carcinomes › Adénocarcinome › Common variability in oestrogen-related genes...
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Carcinome du canal pancréatique › Common variability in oestrogen-related genes...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › Oestrogènes › Common variability in oestrogen-related genes...
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Common variability in oestrogen-related genes...
questionsmedicales.fr › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de la progestérone › Prégnénolone › Common variability in oestrogen-related genes...
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Common variability in oestrogen-related genes...