Tachygastria in Preterm Infants: A Longitudinal Cohort Study.
Journal
Journal of pediatric gastroenterology and nutrition
ISSN: 1536-4801
Titre abrégé: J Pediatr Gastroenterol Nutr
Pays: United States
ID NLM: 8211545
Informations de publication
Date de publication:
01 11 2022
01 11 2022
Historique:
entrez:
28
10
2022
pubmed:
29
10
2022
medline:
2
11
2022
Statut:
ppublish
Résumé
Tachygastria is a gastric dysrhythmia (>4 to ≤9 cycles per minute, cpm) associated with gastric hypomotility and gastrointestinal disorders. Healthy preterm infants spend more time in tachygastria than adults; however, normative values are not defined. We sought to determine the percent of time preterm infants spend in tachygastria. We conducted a longitudinal, prospective cohort study with weekly electrogastrography (EGG) recordings in 51 preterm <34 weeks' gestation and 5 term (reference) infants. We calculated percentage recording time in tachygastria (% tachygastria) and determined the mean ± standard deviation (SD) across EGG sessions. Mixed effects model was performed to test weekly variance in % tachygastria and gestational age effect. Successive pre- and post-prandial measurements were obtained to assess reproducibility of % tachygastria. We compared time to achieve full feeds between subjects with % tachygastria within 1 SD from the mean versus % tachygastria >1 SD from mean. Three hundred seventy-six EGG sessions were completed (N = 56). Mean % tachygastria was 40% with SD ±5%. We demonstrated no change in % tachygastria across 9 postnatal weeks (P = 0.70) and no gestational age effect. No difference was demonstrated between successive pre- (P = 0.91) and post-prandial (P = 0.96) % tachygastria. Infants with 35%-45% tachygastria (within 1 SD from mean) had higher gestational age and less time to achieve full feeds than infants with <35% or >45% tachygastria. EGG is a reproducible tool to assess % tachygastria in preterm infants. Clinical significance of increased or decreased % tachygastria needs further investigation to validate if 35%-45% tachygastria is safe for feeding.
Identifiants
pubmed: 36305880
doi: 10.1097/MPG.0000000000003575
pii: 00005176-202211000-00004
pmc: PMC9627630
mid: NIHMS1830426
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
564-571Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR003163
Pays : United States
Organisme : NIDDK NIH HHS
ID : K08 DK100545
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR003981
Pays : United States
Organisme : NIAID NIH HHS
ID : K24 AI150992
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK121975
Pays : United States
Informations de copyright
Copyright © 2022 by European Society for European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.
Déclaration de conflit d'intérêts
E.B.O., J.-H.C., and J.N. share Patent #US10478116 B2 (University of Florida Research Foundation, Inc.), there are no competing financial interests. J.N. receives research support from Infant Bacterial Therapeutics and is a consultant for Astarte. R.S. is a consultant for Allergan and is a member on the Speaker’s Bureau for Abbott Nutrition. The remaining authors report no conflicts of interest.
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