The efficacy of acoustic-based articulatory phenotyping for characterizing and classifying four divergent neurodegenerative diseases using sequential motion rates.
Acoustic analyses
Articulatory features
Differential diagnosis
Domain knowledge
Neurodegenerative disease
Journal
Journal of neural transmission (Vienna, Austria : 1996)
ISSN: 1435-1463
Titre abrégé: J Neural Transm (Vienna)
Pays: Austria
ID NLM: 9702341
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
26
07
2022
accepted:
13
10
2022
pubmed:
29
10
2022
medline:
15
11
2022
entrez:
28
10
2022
Statut:
ppublish
Résumé
Despite the impacts of neurodegeneration on speech function, little is known about how to comprehensively characterize the resulting speech abnormalities using a set of objective measures. Quantitative phenotyping of speech motor impairments may have important implications for identifying clinical syndromes and their underlying etiologies, monitoring disease progression over time, and improving treatment efficacy. The goal of this research was to investigate the validity and classification accuracy of comprehensive acoustic-based articulatory phenotypes in speakers with distinct neurodegenerative diseases. Articulatory phenotypes were characterized based on acoustic features that were selected to represent five components of motor performance: Coordination, Consistency, Speed, Precision, and Rate. The phenotypes were first used to characterize the articulatory abnormalities across four progressive neurologic diseases known to have divergent speech motor deficits: amyotrophic lateral sclerosis (ALS), progressive ataxia (PA), Parkinson's disease (PD), and the nonfluent variant of primary progressive aphasia and progressive apraxia of speech (nfPPA + PAOS). We then examined the efficacy of articulatory phenotyping for disease classification. Acoustic analyses were conducted on audio recordings of 217 participants (i.e., 46 ALS, 52 PA, 60 PD, 20 nfPPA + PAOS, and 39 controls) during a sequential speech task. Results revealed evidence of distinct articulatory phenotypes for the four clinical groups and that the phenotypes demonstrated strong classification accuracy for all groups except ALS. Our results highlight the phenotypic variability present across neurodegenerative diseases, which, in turn, may inform (1) the differential diagnosis of neurological diseases and (2) the development of sensitive outcome measures for monitoring disease progression or assessing treatment efficacy.
Identifiants
pubmed: 36305960
doi: 10.1007/s00702-022-02550-0
pii: 10.1007/s00702-022-02550-0
pmc: PMC9859630
mid: NIHMS1862557
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1487-1511Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC014296
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC013547
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01DC014296
Pays : United States
Organisme : NIDCD NIH HHS
ID : F31 DC019556
Pays : United States
Organisme : NIDCD NIH HHS
ID : K24 DC016312
Pays : United States
Organisme : NIDCD NIH HHS
ID : F31DC019556
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01DC013547
Pays : United States
Organisme : NIDCD NIH HHS
ID : R21 DC019567
Pays : United States
Organisme : NIDCD NIH HHS
ID : 24DC016312
Pays : United States
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.
Références
J Speech Lang Hear Res. 2012 Feb;55(1):290-305
pubmed: 22199185
Hum Mov Sci. 2005 Oct-Dec;24(5-6):710-30
pubmed: 16337020
Brain Lang. 2002 Mar;80(3):556-75
pubmed: 11896657
Ann Clin Transl Neurol. 2019 Apr 03;6(5):873-881
pubmed: 31139685
Amyotroph Lateral Scler. 2010 May 3;11(3):303-11
pubmed: 20433413
J Acoust Soc Am. 2011 Jan;129(1):350-67
pubmed: 21303016
Front Neurol. 2021 Feb 05;11:616062
pubmed: 33613419
AMA Arch Neurol Psychiatry. 1953 Feb;69(2):171-92
pubmed: 13007227
Neurology. 1988 Feb;38(2):281-3
pubmed: 3340294
Neurol Sci. 2016 Feb;37(2):293-6
pubmed: 26377098
Front Neurol. 2021 Jun 16;12:664713
pubmed: 34220673
J Speech Lang Hear Res. 2014 Feb;57(1):57-67
pubmed: 24687467
Eur Neurol. 1996;36(5):310-4
pubmed: 8864714
J Speech Lang Hear Res. 2017 Dec 20;60(12):3378-3392
pubmed: 29181537
J Speech Lang Hear Res. 2004 Aug;47(4):766-83
pubmed: 15324285
J Speech Lang Hear Res. 2011 Oct;54(5):1247-59
pubmed: 21386044
Amyotroph Lateral Scler Frontotemporal Degener. 2013 Dec;14(7-8):494-500
pubmed: 23898888
Brain Lang. 1993 May;44(4):431-45
pubmed: 8319082
Brain Cogn. 2019 Mar;130:1-10
pubmed: 30622034
Folia Phoniatr Logop. 1995;47(1):15-23
pubmed: 7728177
Brain. 2010 Jul;133(Pt 7):2069-88
pubmed: 20542982
Int J Speech Lang Pathol. 2017 Apr;19(2):195-204
pubmed: 27336197
NPJ Digit Med. 2021 Oct 28;4(1):153
pubmed: 34711924
Mov Disord. 2017 Aug;32(8):1147-1154
pubmed: 28605054
Brain Lang. 1994 Aug;47(2):182-96
pubmed: 7953613
J Neurosci. 2017 Sep 20;37(38):9249-9258
pubmed: 28842410
J Speech Hear Res. 1995 Oct;38(5):1001-13
pubmed: 8558870
J Speech Lang Hear Res. 2017 Apr 14;60(4):S1096-S1117
pubmed: 28384779
Emerg (Tehran). 2016 Spring;4(2):111-3
pubmed: 27274525
Folia Phoniatr Logop. 2012;64(2):94-102
pubmed: 22555651
J Neurol. 2015;262(4):992-1001
pubmed: 25683763
Neuropsychologia. 2016 Jan 29;81:129-139
pubmed: 26707715
Am J Speech Lang Pathol. 2015 May;24(2):88-100
pubmed: 25654422
J Commun Disord. 1987 Oct;20(5):367-78
pubmed: 3655012
Brain. 1988 Apr;111 ( Pt 2):439-56
pubmed: 3378144
J Neural Transm (Vienna). 2012 Apr;119(4):457-62
pubmed: 22065210
Front Aging Neurosci. 2021 May 06;13:633752
pubmed: 34025389
J Neurol Neurosurg Psychiatry. 1991 Dec;54(12):1093-8
pubmed: 1783924
J Neuropsychiatry Clin Neurosci. 2004 Summer;16(3):367-78
pubmed: 15377747
J Speech Hear Res. 1972 Dec;15(4):763-70
pubmed: 4652397
J Speech Hear Res. 1979 Sep;22(3):627-48
pubmed: 502519
Mov Disord. 2012 Jun;27(7):843-50
pubmed: 22729986
J Acoust Soc Am. 2016 Jan;139(1):481-500
pubmed: 26827042
Nat Rev Dis Primers. 2019 Apr 11;5(1):24
pubmed: 30975995
J Speech Lang Hear Res. 2015 Jun;58(3):576-89
pubmed: 25763998
Int J Lang Commun Disord. 2012 Jan-Feb;47(1):65-76
pubmed: 22268902
J Speech Lang Hear Res. 2017 Apr 14;60(4):897-911
pubmed: 28289749
Clin Linguist Phon. 2003 Sep;17(6):427-45
pubmed: 14564830
Brain Lang. 2005 Sep;94(3):347-66
pubmed: 16098382
Neuropsychologia. 1989;27(6):829-38
pubmed: 2755591
Ann Neurol. 2001 Apr;49(4):425-32
pubmed: 11310619
Neurology. 2019 Apr 23;92(17):e1992-e2004
pubmed: 30944238
Clin Linguist Phon. 2009 Nov;23(11):825-41
pubmed: 19891523
Amyotroph Lateral Scler Other Motor Neuron Disord. 2000 Dec;1(5):293-9
pubmed: 11464847
NPJ Parkinsons Dis. 2022 Mar 7;8(1):22
pubmed: 35256614
Neurobiol Aging. 2003 Mar-Apr;24(2):197-211
pubmed: 12498954
Folia Phoniatr (Basel). 1986;38(2-4):61-88
pubmed: 3527898
Arch Neurol. 2008 Oct;65(10):1296-303
pubmed: 18852343
Behav Neurol. 2015;2015:183027
pubmed: 26136624
J Speech Lang Hear Res. 2008 Jun;51(3):596-611
pubmed: 18506038
Trends Neurosci. 2008 Jun;31(6):265-72
pubmed: 18471906
J Commun Disord. 2016 Jul-Aug;62:30-44
pubmed: 27219893
Clin Biomech (Bristol, Avon). 2005 May;20(4):381-8
pubmed: 15737445
Logoped Phoniatr Vocol. 2007;32(1):31-46
pubmed: 17454658
Exp Brain Res. 1986;65(1):156-66
pubmed: 3803501
Neuromodulation. 2017 Apr;20(3):223-232
pubmed: 28160355
Folia Phoniatr Logop. 2008;60(1):11-9
pubmed: 18057906
Can J Neurol Sci. 1993 May;20 Suppl 3:S83-92
pubmed: 8334598
Mov Disord. 2012 Feb;27(2):316-9
pubmed: 22109901
Amyotroph Lateral Scler Frontotemporal Degener. 2020 Feb;21(1-2):42-50
pubmed: 32138555
Amyotroph Lateral Scler Frontotemporal Degener. 2017 Aug;18(5-6):358-366
pubmed: 28355886
J Neurol. 2018 Sep;265(9):2060-2070
pubmed: 29968200
J Speech Lang Hear Res. 2011 Oct;54(5):1302-11
pubmed: 21646421
J Acoust Soc Am. 1989 Jun;85(6):2608-22
pubmed: 2745883
Mov Disord. 2015 Oct;30(12):1591-601
pubmed: 26474316
Neurology. 2011 Mar 15;76(11):1006-14
pubmed: 21325651
Neurology. 2017 Aug 22;89(8):837-844
pubmed: 28733335
J Speech Lang Hear Res. 2016 Oct 1;59(5):887-899
pubmed: 27679842
Eur J Neurol. 2022 Jan;29(1):81-90
pubmed: 34498329
Aphasiology. 2014 Aug;28(8-9):1004-1017
pubmed: 25309017
J Speech Hear Res. 1994 Feb;37(1):28-37
pubmed: 8170127
J Speech Lang Hear Res. 2021 Nov 8;64(11):4178-4191
pubmed: 34699273
Neurosci Biobehav Rev. 2017 Apr;75:378-392
pubmed: 28163193
Brain Lang. 1997 Feb 15;56(3):321-33
pubmed: 9070415
J Speech Lang Hear Res. 2021 Mar 17;64(3):691-706
pubmed: 33561361
Folia Phoniatr Logop. 2004 Nov-Dec;56(6):367-80
pubmed: 15557775
J Commun Disord. 2017 Nov;70:1-11
pubmed: 29032347
Int J Lang Commun Disord. 2016 Jul;51(4):430-41
pubmed: 26914169
J Speech Lang Hear Res. 2021 Dec 13;64(12):4736-4753
pubmed: 34735295
J Speech Lang Hear Res. 2011 Apr;54(2):417-29
pubmed: 20884780
Mov Disord. 2010 Jan 15;25(1):108-11
pubmed: 20014117
Folia Phoniatr Logop. 2013;65(4):214-20
pubmed: 24504015
Folia Phoniatr (Basel). 1990;42(3):125-34
pubmed: 2379900
Folia Phoniatr Logop. 2003 Sep-Oct;55(5):241-59
pubmed: 12931058
J Speech Lang Hear Res. 2017 Apr 14;60(4):S1153-S1169
pubmed: 28384662
J Commun Disord. 2014 Sep-Oct;51:43-50
pubmed: 25092638
J Speech Hear Res. 1983 Jun;26(2):231-49
pubmed: 6887810
Br J Clin Pharmacol. 2018 Dec;84(12):2849-2856
pubmed: 30152872
J Psycholinguist Res. 1973 Mar;2(1):51-81
pubmed: 24197795
Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul;2018:425-428
pubmed: 30440424
Neurology. 1996 Jul;47(1):208-14
pubmed: 8710079
Clin Linguist Phon. 1992;6(1-2):77-85
pubmed: 20672885
J Speech Lang Hear Res. 2017 Apr 14;60(4):S1118-S1134
pubmed: 28384803
J Speech Lang Hear Res. 2022 Feb 9;65(2):574-623
pubmed: 34958599
Mult Scler Relat Disord. 2018 Jan;19:62-69
pubmed: 29149697
Folia Phoniatr Logop. 1997;49(2):63-82
pubmed: 9197089
Folia Phoniatr Logop. 2009;61(6):329-35
pubmed: 19864914
Cerebellum. 2007;6(3):202-13
pubmed: 17786816
Mov Disord. 2011 Jan;26(1):59-64
pubmed: 20945431
Arch Bronconeumol. 2012 Mar;48(3):86-98
pubmed: 22196477
J Voice. 2021 Aug 5;:
pubmed: 34366193
Folia Phoniatr Logop. 2009;61(1):1-11
pubmed: 19088478
Folia Phoniatr Logop. 2001 Jan-Feb;53(1):1-18
pubmed: 11125256
J Commun Disord. 2002 May-Jun;35(3):283-92
pubmed: 12064788
Clin Linguist Phon. 2014 Nov;28(11):799-811
pubmed: 24724615
Med Sci Sports Exerc. 2004 Feb;36(2):233-40
pubmed: 14767245
J Voice. 2011 Nov;25(6):725-31
pubmed: 20457507
J Acoust Soc Am. 2003 Jun;113(6):3362-78
pubmed: 12822807
Neurocase. 2005 Dec;11(6):427-32
pubmed: 16393756
Aphasiology. 2021;35(4):560-591
pubmed: 34219857
Brain. 2012 May;135(Pt 5):1522-36
pubmed: 22382356
Cerebellum. 2007;6(1):58-65
pubmed: 17366266
J Speech Lang Hear Res. 2019 Jan 22;63(1):59-73
pubmed: 31940257
J Speech Hear Res. 1994 Jun;37(3):496-503
pubmed: 8084181
NPJ Parkinsons Dis. 2021 Nov 11;7(1):98
pubmed: 34764299
Aphasiology. 2021;35(4):424-441
pubmed: 34108793
J Acoust Soc Am. 1992 Feb;91(2):1085-98
pubmed: 1556310
J Speech Lang Hear Res. 2017 Apr 14;60(4):S1135-S1152
pubmed: 28384751
J Neurol. 2015 Jan;262(1):21-6
pubmed: 25267338
Cortex. 2012 Sep;48(8):963-71
pubmed: 21513930
J Neurol Neurosurg Psychiatry. 2015 Aug;86(8):856-64
pubmed: 25280914
J Speech Lang Hear Res. 2006 Apr;49(2):395-411
pubmed: 16671852
J Speech Lang Hear Res. 2014 Oct;57(5):1666-78
pubmed: 24824584
Folia Phoniatr Logop. 2001 Mar-Apr;53(2):67-72
pubmed: 11244280
Span J Psychol. 2012 Jul;15(2):495-504
pubmed: 22774423
Brain Lang. 2018 Sep;184:54-65
pubmed: 29980072
J Speech Hear Res. 1975 Dec;18(4):686-706
pubmed: 1207100
J Speech Hear Disord. 1982 Aug;47(3):324-8
pubmed: 7186569
Am J Speech Lang Pathol. 2021 Mar 26;30(2):503-516
pubmed: 33689471
Brain Lang. 2017 May;168:84-94
pubmed: 28187331
Lang Cogn Process. 2011 Jan 1;26(7):952-981
pubmed: 23667281
Folia Phoniatr Logop. 2006;58(2):114-31
pubmed: 16479133
J Speech Lang Hear Res. 2014 Dec;57(6):2051-64
pubmed: 25057892
Am J Speech Lang Pathol. 2021 Jun 18;30(3S):1459-1476
pubmed: 33719528
Neurology. 2021 Nov 23;97(21):e2124-e2135
pubmed: 34607922
J Cogn Neurosci. 2016 Feb;28(2):210-22
pubmed: 26544920
Front Neurol. 2017 Aug 22;8:432
pubmed: 28878734
J Speech Lang Hear Res. 2005 Dec;48(6):1294-310
pubmed: 16478372
Am J Speech Lang Pathol. 2019 Jul 15;28(2S):887-894
pubmed: 31306601
J Commun Disord. 2011 Jul-Aug;44(4):478-92
pubmed: 21592489
Ann N Y Acad Sci. 2002 Dec;978:302-17
pubmed: 12582062
J Neurol. 2019 Jun;266(6):1394-1404
pubmed: 30859316
Brain Lang. 2017 Feb;165:1-9
pubmed: 27894006
Aphasiology. 2017;31(2):241-260
pubmed: 28757671
J Speech Hear Res. 1969 Jun;12(2):246-69
pubmed: 5808852
J Speech Hear Res. 1969 Sep;12(3):462-96
pubmed: 5811846
J Speech Hear Res. 1993 Aug;36(4):683-93
pubmed: 8377481