Unconventional MAIT cell responses to bacterial infections.
Journal
Seminars in immunology
ISSN: 1096-3618
Titre abrégé: Semin Immunol
Pays: England
ID NLM: 9009458
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
pubmed:
29
10
2022
medline:
15
12
2022
entrez:
28
10
2022
Statut:
ppublish
Résumé
Mucosal Associated Invariant T cells (MAIT) exert potent antimicrobial activity through direct recognition of metabolite-MR1 complexes and indirect activation by inflammatory cytokines. Additionally, via licensing of antigen presenting cells, MAIT cells orchestrate humoral and cellular adaptive immunity. Our recent understanding of molecular mechanisms of MAIT cell activation, and of the signals required to differentiate them in polarised subsets, pave the way for harnessing their functionality through small molecules or adoptive cell therapy.
Identifiants
pubmed: 36306661
pii: S1044-5323(22)00081-1
doi: 10.1016/j.smim.2022.101663
pii:
doi:
Substances chimiques
Cytokines
0
Histocompatibility Antigens Class I
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
101663Informations de copyright
Copyright © 2022. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of financial conflict MS is an employee of Immunocore.