Conditional Loss of Nmp4 in Mesenchymal Stem Progenitor Cells Enhances PTH-Induced Bone Formation.
BONE ANABOLISM
OSTEOANABOLICS
OSTEOPOROSIS
TERIPARATIDE
Journal
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
ISSN: 1523-4681
Titre abrégé: J Bone Miner Res
Pays: United States
ID NLM: 8610640
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
revised:
12
10
2022
received:
27
06
2022
accepted:
29
10
2022
pmc-release:
01
01
2024
pubmed:
3
11
2022
medline:
10
1
2023
entrez:
2
11
2022
Statut:
ppublish
Résumé
Activation of bone anabolic pathways is a fruitful approach for treating severe osteoporosis, yet FDA-approved osteoanabolics, eg, parathyroid hormone (PTH), have limited efficacy. Improving their potency is a promising strategy for maximizing bone anabolic output. Nmp4 (Nuclear Matrix Protein 4) global knockout mice exhibit enhanced PTH-induced increases in trabecular bone but display no overt baseline skeletal phenotype. Nmp4 is expressed in all tissues; therefore, to determine which cell type is responsible for driving the beneficial effects of Nmp4 inhibition, we conditionally removed this gene from cells at distinct stages of osteogenic differentiation. Nmp4-floxed (Nmp4
Identifiants
pubmed: 36321253
doi: 10.1002/jbmr.4732
pmc: PMC9825665
mid: NIHMS1847023
doi:
Substances chimiques
Homeodomain Proteins
0
Parathyroid Hormone
0
PRRX1 protein, human
0
ZNF384 protein, human
0
Zfp384 protein, mouse
0
PTH protein, human
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
70-85Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR073739
Pays : United States
Organisme : BLRD VA
ID : I01 BX005861
Pays : United States
Organisme : BLRD VA
ID : IK6 BX003783
Pays : United States
Organisme : BLRD VA
ID : I01 BX005154
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR053237
Pays : United States
Organisme : NIAMS NIH HHS
ID : T32 AR065971
Pays : United States
Informations de copyright
© 2022 American Society for Bone and Mineral Research (ASBMR).
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