Coupling-dependent metabolic ultradian rhythms in confluent cells.
cellular metabolism
gap junctions
ion channels
membrane potential
ultradian rhythms
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
08 Nov 2022
08 Nov 2022
Historique:
entrez:
2
11
2022
pubmed:
3
11
2022
medline:
5
11
2022
Statut:
ppublish
Résumé
Ultradian rhythms in metabolism and physiology have been described previously in mammals. However, the underlying mechanisms for these rhythms are still elusive. Here, we report the discovery of temperature-sensitive ultradian rhythms in mammalian fibroblasts that are independent of both the cell cycle and the circadian clock. The period in each culture is stable over time but varies in different cultures (ranging from 3 to 24 h). We show that transient, single-cell metabolic pulses are synchronized into stable ultradian rhythms across contacting cells in culture by gap junction-mediated coupling. Coordinated rhythms are also apparent for other metabolic and physiological measures, including plasma membrane potential (Δψ
Identifiants
pubmed: 36322771
doi: 10.1073/pnas.2211142119
pmc: PMC9659342
doi:
Substances chimiques
Ketoglutaric Acids
0
Glutamine
0RH81L854J
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2211142119Subventions
Organisme : Howard Hughes Medical Institute (HHMI)
ID : H012233
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