The cooperative folding of annexin A2 relies on a transient nonnative intermediate.


Journal

Biophysical journal
ISSN: 1542-0086
Titre abrégé: Biophys J
Pays: United States
ID NLM: 0370626

Informations de publication

Date de publication:
06 12 2022
Historique:
received: 04 03 2022
revised: 29 06 2022
accepted: 28 10 2022
pubmed: 4 11 2022
medline: 15 12 2022
entrez: 3 11 2022
Statut: ppublish

Résumé

Annexins (Anxs) are a family of highly homologous proteins that bind and aggregate lipid vesicles in the presence of calcium. All members of the family contain a variable N-terminus determining specific functions, followed by a conserved core region responsible for the general calcium-dependent lipid-binding property. The core structure consists of four homologous domains (D

Identifiants

pubmed: 36325614
pii: S0006-3495(22)00897-9
doi: 10.1016/j.bpj.2022.10.043
pmc: PMC9748365
pii:
doi:

Substances chimiques

Annexin A2 0
Calcium SY7Q814VUP
Lipids 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

4492-4504

Informations de copyright

Copyright © 2022 Biophysical Society. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

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Auteurs

Hanne Hollås (H)

Department of Biomedicine, University of Bergen, Bergen, Norway.

Juan Ramirez (J)

Équipe Labellisée Ligue 2015, Department of Integrated Structural Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM U1258/CNRS UMR 7104/Université de Strasbourg, Illkirch, France.

Yves Nominé (Y)

Équipe Labellisée Ligue 2015, Department of Integrated Structural Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM U1258/CNRS UMR 7104/Université de Strasbourg, Illkirch, France.

Camille Kostmann (C)

Équipe Labellisée Ligue 2015, Department of Integrated Structural Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM U1258/CNRS UMR 7104/Université de Strasbourg, Illkirch, France.

Angelo Toto (A)

Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.

Stefano Gianni (S)

Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.

Gilles Travé (G)

Équipe Labellisée Ligue 2015, Department of Integrated Structural Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM U1258/CNRS UMR 7104/Université de Strasbourg, Illkirch, France. Electronic address: gilles.trave@unistra.fr.

Anni Vedeler (A)

Department of Biomedicine, University of Bergen, Bergen, Norway. Electronic address: anni.vedeler@biomed.uib.no.

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Classifications MeSH