Mortality and neurodevelopmental outcomes of infants with spontaneous intestinal perforation: a systematic review and meta-analysis.
infant development
intensive care units, neonatal
neonatology
Journal
Archives of disease in childhood. Fetal and neonatal edition
ISSN: 1468-2052
Titre abrégé: Arch Dis Child Fetal Neonatal Ed
Pays: England
ID NLM: 9501297
Informations de publication
Date de publication:
May 2023
May 2023
Historique:
received:
17
03
2022
accepted:
06
10
2022
medline:
21
4
2023
pubmed:
4
11
2022
entrez:
3
11
2022
Statut:
ppublish
Résumé
There is limited information about the mortality and neurodevelopmental outcomes of very preterm infants (<32 weeks) with spontaneous intestinal perforation (SIP). To explore the association between SIP and neurodevelopmental outcomes and mortality in very preterm infants. Medline, EMBASE, Cochrane Library, EMCARE and MedNar. Databases were searched until September 2021. Studies comparing outcomes of 'SIP' versus 'no SIP or necrotising enterocolitis (NEC)' were included. Neurodevelopmental outcomes at ≥1 year corrected age were extracted as the main outcome measure. Data were pooled separately for adjusted and unadjusted ORs using the random-effects model. The evidence level was assessed using the GRADE (Grading of Recommendations, Assessments, Development and Evaluations) framework. Eighteen cohort studies (13 606 infants) were included. Meta-analysis of unadjusted ORs showed that SIP was significantly associated with increased odds of mortality, cerebral palsy, composite outcome of death or disability, visual impairment and hearing impairment. However, pooling of adjusted ORs (aOR) found significant associations only for mortality (aOR (95% CI) 2.27 (2.07 to 2.49); I Lack of information on aORs from many studies. SIP in very preterm infants is associated with higher odds of mortality, severe disability, and
Sections du résumé
BACKGROUND
BACKGROUND
There is limited information about the mortality and neurodevelopmental outcomes of very preterm infants (<32 weeks) with spontaneous intestinal perforation (SIP).
OBJECTIVE
OBJECTIVE
To explore the association between SIP and neurodevelopmental outcomes and mortality in very preterm infants.
DATA SOURCES
METHODS
Medline, EMBASE, Cochrane Library, EMCARE and MedNar.
STUDY SELECTION
METHODS
Databases were searched until September 2021. Studies comparing outcomes of 'SIP' versus 'no SIP or necrotising enterocolitis (NEC)' were included.
DATA EXTRACTION
METHODS
Neurodevelopmental outcomes at ≥1 year corrected age were extracted as the main outcome measure. Data were pooled separately for adjusted and unadjusted ORs using the random-effects model. The evidence level was assessed using the GRADE (Grading of Recommendations, Assessments, Development and Evaluations) framework.
RESULTS
RESULTS
Eighteen cohort studies (13 606 infants) were included. Meta-analysis of unadjusted ORs showed that SIP was significantly associated with increased odds of mortality, cerebral palsy, composite outcome of death or disability, visual impairment and hearing impairment. However, pooling of adjusted ORs (aOR) found significant associations only for mortality (aOR (95% CI) 2.27 (2.07 to 2.49); I
LIMITATIONS
CONCLUSIONS
Lack of information on aORs from many studies.
CONCLUSIONS
CONCLUSIONS
SIP in very preterm infants is associated with higher odds of mortality, severe disability, and
Identifiants
pubmed: 36328412
pii: archdischild-2022-324157
doi: 10.1136/archdischild-2022-324157
doi:
Types de publication
Meta-Analysis
Systematic Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
256-266Informations de copyright
© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.