The effect of almond intake on cardiometabolic risk factors, inflammatory markers, and liver enzymes: A systematic review and meta-analysis.
almond
blood lipids
cardiometabolic
glycemic control
hepatic enzymes
inflammation
Journal
Phytotherapy research : PTR
ISSN: 1099-1573
Titre abrégé: Phytother Res
Pays: England
ID NLM: 8904486
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
revised:
06
07
2022
received:
29
05
2021
accepted:
20
08
2022
pubmed:
5
11
2022
medline:
15
12
2022
entrez:
4
11
2022
Statut:
ppublish
Résumé
Almond intake may be correlated with improvements in several cardiometabolic parameters, but its effects are controversial in the published literature, and it needs to be comprehensively summarized. We conducted a systematic search in several international electronic databases, including MEDLINE, EMBASE, Scopus, Web of Science, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov until April 2021 to identify randomized controlled trials that examined the effects of almond consumption on cardiometabolic risk factors, inflammatory markers, and liver enzymes. Data were pooled using the random-effects model method and presented as standardized mean differences (SMDs) with 95% confidence intervals (CIs). Twenty-six eligible trials were analyzed (n = 1750 participants). Almond intake significantly decreased diastolic blood pressure, total cholesterol, triglyceride, low-density lipoprotein (LDL), non-high-density lipoprotein (HDL), and very LDL (p < 0.05). The effects of almond intake on systolic blood pressure, fasting blood glucose, insulin, hemoglobin A1c, homeostatic model assessment of insulin resistance, C-peptide, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, C-reactive protein (CRP), hs-CRP (high sensitivity C-reactive protein), interleukin 6, tumor necrosis factor-α, ICAM (Intercellular Adhesion Molecule), VCAM (Vascular Cell Adhesion Molecule), homocysteine, HDL, ox-LDL, ApoA1, ApoB, and lipoprotien-a were not statistically significant (p > .05). The current body of evidence supports the ingestion of almonds for their beneficial lipid-lowering and antihypertensive effects. However, the effects of almonds on antiinflammatory markers, glycemic control, and hepatic enzymes should be further evaluated via performing more extensive randomized trials.
Substances chimiques
Transferases
EC 2.-
Types de publication
Meta-Analysis
Systematic Review
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
4325-4344Informations de copyright
© 2022 John Wiley & Sons Ltd.
Références
Abazarfard, Z., Eslamian, G., Salehi, M., & Keshavarzi, S. (2016). A randomized controlled trial of the effects of an almond-enriched, hypocaloric diet on liver function tests in overweight/obese women. Iranian Red Crescent Medical Journal, 18(3), e23628.
Abazarfard, Z., Salehi, M., & Keshavarzi, S. (2014). The effect of almonds on anthropometric measurements and lipid profile in overweight and obese females in a weight reduction program: A randomized controlled clinical trial. Journal of Research in Medical Sciences: The Official Journal of Isfahan University of Medical Sciences, 19(5), 457-464.
Alasalvar, C., & Bolling, B. W. (2015). Review of nut phytochemicals, fat-soluble bioactives, antioxidant components and health effects. The British Journal of Nutrition, 113(Suppl 2), S68-S78.
Barreca, D., Nabavi, S. M., Sureda, A., Rasekhian, M., Raciti, R., Silva, A. S., … Mandalari, G. (2020). Almonds (Prunus Dulcis mill. D. A. Webb): A source of nutrients and health-promoting compounds. Nutrients, 12(3), 672.
Bento, A. P. N., Cominetti, C., Simoes, A., & Naves, M. M. V. (2014). Baru almond improves lipid profile in mildly hypercholesterolemic subjects: A randomized, controlled, crossover study. Nutrition Metabolism and Cardiovascular Diseases, 24(12), 1330-1336.
Berryman, C. E., West, S. G., Fleming, J. A., Bordi, P. L., & Kris-Etherton, P. M. (2015). Effects of daily almond consumption on cardiometabolic risk and abdominal adiposity in healthy adults with elevated LDL-cholesterol: A randomized controlled trial. Journal of the American Heart Association, 4(1), e000993.
Blomhoff, R., Carlsen, M. H., Andersen, L. F., & Jacobs, D. R., Jr. (2006). Health benefits of nuts: Potential role of antioxidants. The British Journal of Nutrition, 96(Suppl 2), S52-S60.
Bolling, B. W., Chen, C. Y., McKay, D. L., & Blumberg, J. B. (2011). Tree nut phytochemicals: Composition, antioxidant capacity, bioactivity, impact factors. A systematic review of almonds, brazils, cashews, hazelnuts, macadamias, pecans, pine nuts, pistachios and walnuts. Nutrition Research Reviews, 24(2), 244-275.
Bowen, J., Luscombe-Marsh, N. D., Stonehouse, W., Tran, C., Rogers, G. B., Johnson, N., … Brinkworth, G. D. (2019). Effects of almond consumption on metabolic function and liver fat in overweight and obese adults with elevated fasting blood glucose: A randomised controlled trial. Clinical Nutrition ESPEN, 30, 10-18.
Chen, C. M., Liu, J. F., Li, S. C., Huang, C. L., Hsirh, A. T., Weng, S. F., … Chen, C. Y. (2017). Almonds ameliorate glycemic control in Chinese patients with better controlled type 2 diabetes: A randomized, crossover, controlled feeding trial. Nutrition and Metabolism, 14(1), 1-12.
Chen, C. Y., Milbury, P. E., Chung, S. K., & Blumberg, J. (2007). Effect of almond skin polyphenolics and quercetin on human LDL and apolipoprotein B-100 oxidation and conformation. The Journal of Nutritional Biochemistry, 18(12), 785-794.
Chen, C. Y. O., Holbrook, M., Duess, M. A., Dohadwala, M. M., Hamburg, N. M., Asztalos, B. F., … Vita, J. A. (2015). Effect of almond consumption on vascular function in patients with coronary artery disease: A randomized, controlled, crossover trial. Nutrition Journal, 14(1), 61.
Coates, A. M., Morgillo, S., Yandell, C., Scholey, A., Buckley, J. D., Dyer, K. A., & Hill, A. M. (2020). Effect of a 12-week almond-enriched diet on biomarkers of cognitive performance, mood, and cardiometabolic health in older overweight adults. Nutrients, 12(4), 1180.
Cohen, A. E., & Johnston, C. S. (2011). Almond ingestion at mealtime reduces postprandial glycemia and chronic ingestion reduces hemoglobin A1c in individuals with well-controlled type 2 diabetes mellitus. Metabolism: Clinical and Experimental, 60(9), 1312-1317.
Cohen, J. (2013). Statistical power analysis for the behavioral sciences. New York, Routledge. Academic Press.
de Souza, R. G. M., Gomes, A. C., de Castro, I. A., & Mota, J. F. (2018). A baru almond-enriched diet reduces abdominal adiposity and improves high-density lipoprotein concentrations: A randomized, placebo-controlled trial. Nutrition, 55, 154-160.
de Souza, R. G. M., Gomes, A. C., Navarro, A. M., Cunha, L. C. D., Silva, M. A. C., Junior, F. B., & Mota, J. F. (2019). Baru almonds increase the activity of glutathione peroxidase in overweight and obese women: A randomized, Placebo-Controlled Trial. Nutrients, 11(8), 1750.
Del Gobbo, L. C., Falk, M. C., Feldman, R., Lewis, K., & Mozaffarian, D. (2015). Effects of tree nuts on blood lipids, apolipoproteins, and blood pressure: Systematic review, meta-analysis, and dose-response of 61 controlled intervention trials. The American Journal of Clinical Nutrition, 102(6), 1347-1356.
Dhillon, J., Thorwald, M., De la Cruz, N., Vu, E., Asghar, S. A., Kuse, Q., … Ortiz, R. M. (2018). Glucoregulatory and Cardiometabolic profiles of almond vs. cracker snacking for 8 weeks in young adults: A randomized controlled trial. Nutrients, 10(8), 960.
Di Angelantonio, E., Kaptoge, S., Wormser, D., Willeit, P., Butterworth, A. S., Bansal, N., … Freitag, D. F. (2015). Association of Cardiometabolic Multimorbidity with Mortality. JAMA, 314(1), 52-60.
Dikariyanto, V., Smith, L., Francis, L., Robertson, M., Kusaslan, E., O'Callaghan-Latham, M., … Whitcher, B. (2020). Snacking on whole almonds for 6 weeks improves endothelial function and lowers LDL cholesterol but does not affect liver fat and other cardiometabolic risk factors in healthy adults: The ATTIS study, a randomized controlled trial. The American Journal of Clinical Nutrition, 111(6), 1178-1189.
Eckel, R. H., Jakicic, J. M., Ard, J. D., de Jesus, J. M., Houston Miller, N., Hubbard, V. S., … American College of Cardiology/American Heart Association Task Force on Practice Guidelines. (2014). 2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk: A report of the American College of Cardiology/American Heart Association task force on practice guidelines. Circulation, 129(25 Suppl 2), S76-S99.
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315(7109), 629-634.
Eslampour, E., Asbaghi, O., Hadi, A., Abedi, S., Ghaedi, E., Lazaridi, A. V., & Miraghajani, M. (2020). The effect of almond intake on blood pressure: A systematic review and meta-analysis of randomized controlled trials. Complementary Therapies in Medicine, 50, 102399.
Fox, C. S., Golden, S. H., Anderson, C., Bray, G. A., Burke, L. E., de Boer, I. H., … Vafiadis, D. K. (2015). Update on prevention of cardiovascular disease in adults with type 2 diabetes mellitus in light of recent evidence: A scientific statement from the American Heart Association and the American Diabetes Association. Diabetes Care, 38(9), 1777-1803.
Galli, F., Azzi, A., Birringer, M., Cook-Mills, J. M., Eggersdorfer, M., Frank, J., … Özer, N. K. (2017). Vitamin E: Emerging aspects and new directions. Free Radical Biology & Medicine, 102, 16-36.
Gambardella, J., Khondkar, W., Morelli, M. B., Wang, X., Santulli, G., & Trimarco, V. (2020). Arginine and endothelial function. Biomedicine, 8(8), 277.
Griel, A. E., & Kris-Etherton, P. M. (2006). Tree nuts and the lipid profile: A review of clinical studies. The British Journal of Nutrition, 96(Suppl 2), S68-S78.
Grundy, S. M., Stone, N. J., Bailey, A. L., Beam, C., Birtcher, K. K., Blumenthal, R. S., … Yeboah, J. (2019). 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the Management of Blood Cholesterol: A report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines. Circulation, 139(25), e1082-e1143.
Gullestad, L., Dolva, L. O., Soyland, E., Manger, A. T., Falch, D., & Kjekshus, J. (1992). Oral magnesium supplementation improves metabolic variables and muscle strength in alcoholics. Alcoholism, Clinical and Experimental Research, 16(5), 986-990.
Hanna, A., & Frangogiannis, N. G. (2020). Inflammatory cytokines and chemokines as therapeutic targets in heart failure. Cardiovascular Drugs and Therapy, 34, 849-863.
Higgins, J. P., & Thompson, S. G. (2002). Quantifying heterogeneity in a meta-analysis. Statistics in Medicine, 21(11), 1539-1558.
Imig, J. D. (2019). Epoxyeicosanoids in hypertension. Physiological Research, 68(5), 695-704.
Izzo, A. A., Hoon-Kim, S., Radhakrishnan, R., & Williamson, E. M. (2016). A critical approach to evaluating clinical efficacy, adverse events and drug interactions of herbal remedies. Phytotherapy Research, 30(5), 691-700.
Jaceldo-Siegl, K., Sabaté, J., Rajaram, S., & Fraser, G. E. (2004). Long-term almond supplementation without advice on food replacement induces favourable nutrient modifications to the habitual diets of free-living individuals. The British Journal of Nutrition, 92(3), 533-540.
Jamshed, H., Sultan, F. A. T., Iqbal, R., & Gilani, A. H. (2015). Dietary almonds increase serum HDL cholesterol in coronary artery disease patients in a randomized controlled Trial1-3. Journal of Nutrition, 145(10), 2287-2292.
Jenkins, D. J., Kendall, C. W., Marchie, A., Josse, A. R., Nguyen, T. H., Faulkner, D. A., … Blumberg, J. (2008a). Almonds reduce biomarkers of lipid peroxidation in older hyperlipidemic subjects. The Journal of Nutrition, 138(5), 908-913.
Jenkins, D. J., Kendall, C. W., Marchie, A., Josse, A. R., Nguyen, T. H., Faulkner, D. A., … Singer, W. (2008b). Effect of almonds on insulin secretion and insulin resistance in nondiabetic hyperlipidemic subjects: A randomized controlled crossover trial. Metabolism: Clinical and Experimental, 57(7), 882-887.
Jenkins, D. J., Kendall, C. W., Marchie, A., Parker, T. L., Connelly, P. W., Qian, W., … Spiller, G. A. (2002). Dose response of almonds on coronary heart disease risk factors: Blood lipids, oxidized low-density lipoproteins, lipoprotein(a), homocysteine, and pulmonary nitric oxide: A randomized, controlled, crossover trial. Circulation, 106(11), 1327-1332.
Jenkins, D. J. A., Kendall, C. W. C., Marchie, A., Josse, A. R., Nguyen, T. H., Faulkner, D. A., … Blumberg, J. (2008). Almonds reduce biomarkers of lipid peroxidation in older hyperlipidemic subjects. Journal of Nutrition, 138(5), 908-913.
Jung, H., Chen, C. Y. O., Blumberg, J. B., & Kwak, H. K. (2018). The effect of almonds on vitamin E status and cardiovascular risk factors in Korean adults: A randomized clinical trial. European Journal of Nutrition, 57(6), 2069-2079.
Lee-Bravatti, M. A., Wang, J., Avendano, E. E., King, L., Johnson, E. J., & Raman, G. (2019). Almond consumption and risk factors for cardiovascular disease: A systematic review and meta-analysis of randomized controlled trials. Advances in Nutrition, 10(6), 1076-1088.
Lelong, H., Galan, P., Kesse-Guyot, E., Fezeu, L., Hercberg, S., & Blacher, J. (2015). Relationship between nutrition and blood pressure: A cross-sectional analysis from the NutriNet-Santé study, a French web-based cohort study. American Journal of Hypertension, 28(3), 362-371.
Li, Z., Bhagavathula, A. S., Batavia, M., Clark, C., Abdulazeem, H. M., Rahmani, J., & Yin, F. (2020). The effect of almonds consumption on blood pressure: A systematic review and dose-response meta-analysis of randomized control trials. Journal of King Saud University-Science, 32(2), 1757-1763.
Liu, J. F., Liu, Y. H., Chen, C. M., Chang, W. H., & Chen, C. Y. O. (2013). The effect of almonds on inflammation and oxidative stress in Chinese patients with type 2 diabetes mellitus: A randomized crossover controlled feeding trial. European Journal of Nutrition, 52(3), 927-935.
Liu, K, Hui, S, Wang, B, Kaliannan, K, Guo, X, Liang, L. 2020. Comparative effects of different types of tree nut consumption on blood lipids: A network meta-analysis of clinical trials. The American Journal of Clinical Nutrition 111(1): 219-227.
Liu, Y., Hwang, H. J., Kim, H. S., & Park, H. (2018). Time and intervention effects of daily almond intake on the changes of lipid profile and body composition among free-living healthy adults. Journal of Medicinal Food, 21(4), 340-347.
Liu, Y., Hwang, H. J., Ryu, H., Lee, Y. S., Kim, H. S., & Park, H. (2017). The effects of daily intake timing of almond on the body composition and blood lipid profile of healthy adults. Nutrition Research and Practice, 11(6), 479-486.
Mazidi, M., Ofori-Asenso, R., George, E. S., & Vatanparast, H. (2020). Association between nutrient patterns and hypertension among adults in the United States: A population-based survey. High Blood Press Cardiovascular Prevention, 27(2), 133-138.
Miranda, J. J., Barrientos-Gutiérrez, T., Corvalan, C., Hyder, A. A., Lazo-Porras, M., Oni, T., & Wells, J. C. K. (2019). Understanding the rise of cardiometabolic diseases in low- and middle-income countries. Nature Medicine, 25(11), 1667-1679.
Moher, D., Liberati, A., Tetzlaff, J., & Altman, D. G. (2010). Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. International Journal of Surgery, 8(5), 336-341.
Mozaffarian, D. (2016). Dietary and policy priorities for cardiovascular disease, diabetes, and obesity: A comprehensive review. Circulation, 133(2), 187-225.
Munteanu, A., & Zingg, J. M. (2007). Cellular, molecular and clinical aspects of vitamin E on atherosclerosis prevention. Molecular Aspects of Medicine, 28(5-6), 538-590.
Musa-Veloso, K., Paulionis, L., Poon, T., & Lee, H. Y. (2016). The effects of almond consumption on fasting blood lipid levels: A systematic review and meta-analysis of randomised controlled trials. The Journal of Nutrition, 5, e34.
Palacios, O. M., Maki, K. C., Xiao, D., Wilcox, M. L., Dicklin, M. R., Kramer, M., … Edirisinghe, I. (2020). Effects of consuming almonds on insulin sensitivity and other Cardiometabolic health markers in adults with prediabetes. Journal of the American College of Nutrition, 39(5), 397-406.
Pervez, M. A., Khan, D. A., Ijaz, A., & Khan, S. (2018). Effects of Delta-tocotrienol supplementation on liver enzymes, inflammation, oxidative stress and hepatic steatosis in patients with nonalcoholic fatty liver disease. The Turkish Journal of Gastroenterology, 29(2), 170-176.
Rajaram, S., Connell, K. M., & Sabate, J. (2010). Effect of almond-enriched high-monounsaturated fat diet on selected markers of inflammation: A randomised, controlled, crossover study. British Journal of Nutrition, 103(6), 907-912.
Ros, E. (2015). Nuts and CVD. The British Journal of Nutrition, 113(Suppl 2), S111-S120.
Savica, V., Bellinghieri, G., & Kopple, J. D. (2010). The effect of nutrition on blood pressure. Annual Review of Nutrition, 30, 365-401.
Schincaglia, R. M., Cuppari, L., Neri, H. F. S., Cintra, D. E., Sant'Ana, M. R., & Mota, J. F. (2020). Effects of baru almond oil (Dipteryx alata Vog.) supplementation on body composition, inflammation, oxidative stress, lipid profile, and plasma fatty acids of hemodialysis patients: A randomized, double-blind, placebo-controlled clinical trial. Complementary Therapies in Medicine, 52, 102479.
Shi, Y., Zou, Y., Shen, Z., Xiong, Y., Zhang, W., Liu, C., & Chen, S. (2020). Trace elements, PPARs, and metabolic syndrome. International Journal of Molecular Sciences, 21(7), 2612.
Tan, S. Y., & Mattes, R. D. (2013). Appetitive, dietary and health effects of almonds consumed with meals or as snacks: A randomized, controlled trial. European Journal of Clinical Nutrition, 67(11), 1205-1214.
Tindall, A. M., Johnston, E. A., Kris-Etherton, P. M., & Petersen, K. S. (2019). The effect of nuts on markers of glycemic control: A systematic review and meta-analysis of randomized controlled trials. The American Journal of Clinical Nutrition, 109(2), 297-314.
Tyrrell, D. J., & Goldstein, D. R. (2020). Ageing and atherosclerosis: Vascular intrinsic and extrinsic factors and potential role of IL-6. Nature Reviews. Cardiology, 18(1), 58-68.
Viguiliouk, E., Kendall, C. W., Blanco Mejia, S., Cozma, A. I., Ha, V., Mirrahimi, A., … Sievenpiper, J. L. (2014). Effect of tree nuts on glycemic control in diabetes: A systematic review and meta-analysis of randomized controlled dietary trials. PLoS One, 9(7), e103376.
Williamson, E. M., Liu, X., & Izzo, A. A. (2020). Trends in use, pharmacology, and clinical applications of emerging herbal nutraceuticals. British Journal of Pharmacology, 177(6), 1227-1240.
Zhao, J. V., & Schooling, C. M. (2019). Effect of linoleic acid on ischemic heart disease and its risk factors: A Mendelian randomization study. BMC Medicine, 17(1), 61.
Zibaeenezhad, M. J., Ostovan, P., Mosavat, S. H., Zamirian, M., & Attar, A. (2019). Almond oil for patients with hyperlipidemia: A randomized open-label controlled clinical trial. Complementary Therapies in Medicine, 42, 33-36.