Use of TIMP-2 and IGFBP-7 for prediction of postoperative acute kidney injury after cardiac surgery.
Journal
Clinical nephrology
ISSN: 0301-0430
Titre abrégé: Clin Nephrol
Pays: Germany
ID NLM: 0364441
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
accepted:
24
11
2022
pubmed:
5
11
2022
medline:
25
2
2023
entrez:
4
11
2022
Statut:
ppublish
Résumé
The following cell cycle arrest urinary biomarkers, tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP-7), have been used for early detection of acute kidney injury (AKI) in critically ill patients. The purpose of this study is to validate the use of these urinary biomarkers in patients undergoing open heart surgery. In a single-center prospective observational study, urine samples were collected in 108 consecutive patients who underwent open heart surgery immediately after separation from cardiopulmonary bypass and on postoperative day 1, and were sent for the biomarker [TIMP-2]*[IGFBP7] analysis. Acute kidney injury was defined based on KDIGO criteria, and levels of [TIMP-2]*[IGFBP7] were analyzed for the ability to predict AKI. Of the 108 patients, 19 (17.6%) patients developed postoperative AKI within 48 hours of surgery. At the threshold of > 0.3 (ng/mL) Urinary [TIMP-2]*[IGFBP7] was not predictive of the risk of AKI after cardiac surgery in this single-center study population.
Sections du résumé
BACKGROUND
BACKGROUND
The following cell cycle arrest urinary biomarkers, tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP-7), have been used for early detection of acute kidney injury (AKI) in critically ill patients. The purpose of this study is to validate the use of these urinary biomarkers in patients undergoing open heart surgery.
MATERIALS AND METHODS
METHODS
In a single-center prospective observational study, urine samples were collected in 108 consecutive patients who underwent open heart surgery immediately after separation from cardiopulmonary bypass and on postoperative day 1, and were sent for the biomarker [TIMP-2]*[IGFBP7] analysis. Acute kidney injury was defined based on KDIGO criteria, and levels of [TIMP-2]*[IGFBP7] were analyzed for the ability to predict AKI.
RESULTS
RESULTS
Of the 108 patients, 19 (17.6%) patients developed postoperative AKI within 48 hours of surgery. At the threshold of > 0.3 (ng/mL)
CONCLUSION
CONCLUSIONS
Urinary [TIMP-2]*[IGFBP7] was not predictive of the risk of AKI after cardiac surgery in this single-center study population.
Identifiants
pubmed: 36331021
pii: 189825
doi: 10.5414/CN110973
doi:
Substances chimiques
insulin-like growth factor binding protein-related protein 1
0
Tissue Inhibitor of Metalloproteinase-2
127497-59-0
Biomarkers
0
Types de publication
Observational Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM