COVID-19 vaccination is associated with reduced non-COVID in-hospital mortality.
COVID-19 vaccination
Efficacy of vaccine
Healthy adherer effect
Israel
Mortality
Retrospective cohort studies
Journal
Preventive medicine
ISSN: 1096-0260
Titre abrégé: Prev Med
Pays: United States
ID NLM: 0322116
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
received:
23
08
2022
revised:
25
10
2022
accepted:
29
10
2022
pubmed:
5
11
2022
medline:
23
11
2022
entrez:
4
11
2022
Statut:
ppublish
Résumé
We retrieved data on a cohort of medical patients at a regional Israeli hospital. The dependent variable was non-COVID-19 hospital mortality; the independent variables were vaccination status, age, and laboratory data. Serum sodium, age, serum creatinine, and COVID-19 vaccination status were the main independent variables associated with non-COVID-19 mortality. The odds ratio for in-hospital deaths of non-vaccinated patients was 2.01 (1.65-2.44) (unadjusted) and 1.61 (1.29-2.03) after adjustment for the independent variables. This "healthy adherer effect" may confound observational assessments of the clinical efficacy of COVID-19 vaccines.
Identifiants
pubmed: 36332771
pii: S0091-7435(22)00376-0
doi: 10.1016/j.ypmed.2022.107326
pmc: PMC9625845
pii:
doi:
Substances chimiques
COVID-19 Vaccines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
107326Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest JB, PF, and ZS declare no competing interests. This study did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors.
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