Founder lineages in the Iberian Roma mitogenomes recapitulate the Roma diaspora and show the effects of demographic bottlenecks.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
04 11 2022
04 11 2022
Historique:
received:
15
06
2022
accepted:
30
10
2022
entrez:
5
11
2022
pubmed:
6
11
2022
medline:
9
11
2022
Statut:
epublish
Résumé
The Roma are the largest ethnic minority in Europe. With a Northwestern Indian origin around ~ 1.5 kya, they travelled throughout West Asia until their arrival in Europe around the eleventh century CE. Their diaspora through Europe is characterized by population bottlenecks and founder events which have contributed to their present day genetic and cultural diversity. In our study, we focus on the effects of founder effects in the mitochondrial DNA (mtDNA) pool of Iberian Roma by producing and analyzing 144 novel whole mtDNA sequences of Iberian Roma. Over 60% of their mtDNA pool is composed by founder lineages of South Asian origin or acquired by gene flow during their diaspora in the Middle East or locally in Europe in Europe. The TMRCA of these lineages predates the historical record of the Roma arrival in Spain. The abundance of founder lineages is in contrast with ~ 0.7% of autochthonous founder lineages present in the non-Roma Iberian population. Within those founder lineages, we found a substantial amount of South Asian M5a1b1a1 haplotypes and high frequencies of West Eurasian founder lineages (U3b1c, J2b1c, J1c1b, J1b3a, H88, among others), which we characterized phylogenetically and put in phylogeographical context. Besides, we found no evidence of genetic substructure of Roma within the Iberian Peninsula. These results show the magnitude of founder effects in the Iberian Roma and further explain the Roma history and genetic diversity from a matrilineal point of view.
Identifiants
pubmed: 36333436
doi: 10.1038/s41598-022-23349-9
pii: 10.1038/s41598-022-23349-9
pmc: PMC9636147
doi:
Substances chimiques
DNA, Mitochondrial
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
18720Subventions
Organisme : Spanish Ministry of Economy and Competitiveness
ID : CGL2016-75389-P
Organisme : Agència de Gestió d'Ajuts Universitaris i de la Recerca (Generalitat de Catalunya)
ID : 2017SGR00702
Informations de copyright
© 2022. The Author(s).
Références
Genome Res. 2010 Sep;20(9):1297-303
pubmed: 20644199
Ann Hum Genet. 2008 Mar;72(Pt 2):215-27
pubmed: 18205888
Int J Mol Sci. 2022 Aug 16;23(16):
pubmed: 36012483
Genet Test. 2007 Winter;11(4):455-8
pubmed: 18294064
Eur J Hum Genet. 2016 Jun;24(6):937-43
pubmed: 26374132
Eur J Hum Genet. 2011 Mar;19(3):326-33
pubmed: 21081970
PLoS One. 2013;8(3):e58633
pubmed: 23516520
Investig Genet. 2015 Mar 10;6:3
pubmed: 25798216
Nat Genet. 1999 Oct;23(2):147
pubmed: 10508508
Eur J Hum Genet. 2015 Jan;23(1):124-31
pubmed: 24667786
PLoS One. 2012;7(11):e48477
pubmed: 23209554
Gene. 2012 Aug 10;504(2):296-302
pubmed: 22609956
Sci Rep. 2021 Sep 13;11(1):18121
pubmed: 34518562
Am J Hum Genet. 2012 Mar 9;90(3):486-93
pubmed: 22365151
Am J Hum Genet. 2011 Apr 8;88(4):433-9
pubmed: 21457906
Curr Biol. 2012 Dec 18;22(24):2342-9
pubmed: 23219723
PLoS One. 2011 Jan 10;6(1):e15988
pubmed: 21264345
Bioinformatics. 2016 Jan 15;32(2):292-4
pubmed: 26428292
Mol Biol Evol. 2020 Nov 1;37(11):3175-3187
pubmed: 32589725
PLoS One. 2018 Sep 10;13(9):e0202890
pubmed: 30199533
PLoS One. 2013 Oct 15;8(10):e75397
pubmed: 24143169
Am J Hum Genet. 2000 Sep;67(3):718-26
pubmed: 10924403
Front Genet. 2019 Jun 13;10:558
pubmed: 31263480
PLoS Genet. 2019 Sep 23;15(9):e1008417
pubmed: 31545809
Nucleic Acids Res. 2016 Jul 8;44(W1):W58-63
pubmed: 27084951
Curr Biol. 2021 May 24;31(10):2167-2177.e4
pubmed: 33770488
Bioinformatics. 2010 Feb 1;26(3):419-20
pubmed: 20080509
Mol Biol Evol. 2021 Jun 25;38(7):2804-2817
pubmed: 33713133
Nature. 2015 Oct 1;526(7571):68-74
pubmed: 26432245
BMC Med Genet. 2001;2:5
pubmed: 11299048
Curr Protoc Bioinformatics. 2013;43:11.10.1-11.10.33
pubmed: 25431634
Front Genet. 2015 Jun 10;6:208
pubmed: 26113860
Int J Mol Sci. 2021 May 27;22(11):
pubmed: 34072215
Sci Rep. 2020 Sep 2;10(1):14464
pubmed: 32879340