The Effect of Thyme Essential Oil on Liver Injuries Caused by Renal Ischemia-Reperfusion in Rats.
Rats
Animals
Male
Caspase 3
/ metabolism
Thymus Plant
Antioxidants
/ metabolism
Oils, Volatile
/ metabolism
Tumor Necrosis Factor-alpha
/ metabolism
Reperfusion Injury
/ metabolism
Interleukin-6
/ metabolism
Liver
/ pathology
Glutathione Peroxidase
/ metabolism
Liver Diseases
/ pathology
Ischemia
/ pathology
Anti-Inflammatory Agents
/ pharmacology
Reperfusion
Oxidative Stress
Journal
BioMed research international
ISSN: 2314-6141
Titre abrégé: Biomed Res Int
Pays: United States
ID NLM: 101600173
Informations de publication
Date de publication:
2022
2022
Historique:
received:
05
08
2022
revised:
23
09
2022
accepted:
04
10
2022
entrez:
7
11
2022
pubmed:
8
11
2022
medline:
9
11
2022
Statut:
epublish
Résumé
Liver damage occurs following renal ischemia-reperfusion (RIR) that can cause inflammation and inflammatory cytokines activated after kidney injury. In this study, thyme essential oil (TE) with antioxidant and anti-inflammatory properties was used to reduce liver damage induced by renal IR. 32 male rats were randomly divided into 4 equal groups: (1) control, (2) RIR, (3) RIR+TE, and (4) TE. Rats received TE as a pretreatment at a dose of 0.5 ml/kg for one week. Then, under anesthesia for 45 minutes for ischemia, the kidneys of the animals were closed with clamps, and reperfusion was performed for 24 hours. Animal serum was isolated to evaluate alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) parameters. The liver of rats was examined for the measurement of malondialdehyde (MDA), nitric oxide (NO), glutathione (GSH), glutathione peroxidase (GPX), catalase (CAT), and expression of genes such as interleukin-6 (IL-6), tumor necrosis factor-
Identifiants
pubmed: 36337844
doi: 10.1155/2022/2988334
pmc: PMC9629959
doi:
Substances chimiques
Caspase 3
EC 3.4.22.-
Antioxidants
0
Oils, Volatile
0
Tumor Necrosis Factor-alpha
0
Interleukin-6
0
Glutathione Peroxidase
EC 1.11.1.9
Anti-Inflammatory Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2988334Informations de copyright
Copyright © 2022 Reza Rostami et al.
Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interest that could be perceived to have influenced this work.
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