Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination.

Humans Antibodies, Neutralizing Antibodies, Viral Autoantibodies COVID-19 / immunology SARS-CoV-2 Spike Glycoprotein, Coronavirus / genetics Toll-Like Receptor 7 / genetics Vaccination mRNA Vaccines COVID-19 Vaccines / immunology B-Lymphocytes / immunology Interferon Type I / deficiency

Journal

The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R

Informations de publication

Date de publication:
02 01 2023
Historique:
received: 11 02 2022
revised: 02 08 2022
accepted: 05 10 2022
entrez: 7 11 2022
pubmed: 8 11 2022
medline: 10 11 2022
Statut: ppublish

Résumé

Inborn and acquired deficits of type I interferon (IFN) immunity predispose to life-threatening COVID-19 pneumonia. We longitudinally profiled the B cell response to mRNA vaccination in SARS-CoV-2 naive patients with inherited TLR7, IRF7, or IFNAR1 deficiency, as well as young patients with autoantibodies neutralizing type I IFNs due to autoimmune polyendocrine syndrome type-1 (APS-1) and older individuals with age-associated autoantibodies to type I IFNs. The receptor-binding domain spike protein (RBD)-specific memory B cell response in all patients was quantitatively and qualitatively similar to healthy donors. Sustained germinal center responses led to accumulation of somatic hypermutations in immunoglobulin heavy chain genes. The amplitude and duration of, and viral neutralization by, RBD-specific IgG serological response were also largely unaffected by TLR7, IRF7, or IFNAR1 deficiencies up to 7 mo after vaccination in all patients. These results suggest that induction of type I IFN is not required for efficient generation of a humoral response against SARS-CoV-2 by mRNA vaccines.

Identifiants

DOI: 10.1084/jem.20220258 PMID: 36342455
pubmed: 36342455
pii: 213666
doi: 10.1084/jem.20220258
pii:
doi:

Substances chimiques

Antibodies, Neutralizing 0
Antibodies, Viral 0
Autoantibodies 0
Spike Glycoprotein, Coronavirus 0
spike protein, SARS-CoV-2 0
Toll-Like Receptor 7 0
mRNA Vaccines 0
COVID-19 Vaccines 0
Interferon Type I 0

Banques de données

ClinicalTrials.gov
['NCT04402892']

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI088364
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001866
Pays : United States
Organisme : NIH HHS
ID : R01AI088364
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States

Informations de copyright

© 2022 Sokal et al.

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Auteurs

Aurélien Sokal (A)

Necker Enfants Malades Institute, INSERM U1151/CNRS UMR 8253, Action thématique incitative sur programme-Avenir Team Auto-Immune and Immune B cell, University Paris Cité, University Paris-Est-Créteil, Créteil, France.
ORCID: 0000-0002-1198-8689

Paul Bastard (P)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Imagine Institute, University Paris Cité, Paris, France.
Department of Pediatrics, Necker Hospital for Sick Children, Assistance Publique-Hôpitaux de Paris, Paris, France.
St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.
ORCID: 0000-0002-5926-8437

Pascal Chappert (P)

Necker Enfants Malades Institute, INSERM U1151/CNRS UMR 8253, Action thématique incitative sur programme-Avenir Team Auto-Immune and Immune B cell, University Paris Cité, University Paris-Est-Créteil, Créteil, France.
INSERM U955, team 2. Mondor Biomedical Research Institute, Paris-Est Créteil University, Créteil, France.
ORCID: 0000-0002-9799-4608

Giovanna Barba-Spaeth (G)

Institut Pasteur, University Paris Cité, CNRS UMR 3569, Structural Virology Unit, Paris, France.
ORCID: 0000-0003-2069-9501

Slim Fourati (S)

Virology, Bacteriology, Hygiene and Mycology-Parasitology, Henri Mondor University Hospital, Assistance Publique-Hôpitaux de Paris, Créteil, France.
INSERM U955, team 18. Mondor Biomedical Research Institute, Paris-Est Créteil University, Créteil, France.
ORCID: 0000-0002-1236-5467

Alexis Vanderberghe (A)

INSERM U955, team 2. Mondor Biomedical Research Institute, Paris-Est Créteil University, Créteil, France.
Departement of Internal Medicine, Henri Mondor University Hospital, Assistance Publique-Hôpitaux de Paris, Paris-Est Créteil University, Créteil, France.
ORCID: 0000-0003-2447-3972

Pauline Lagouge-Roussey (P)

INSERM U955, team 2. Mondor Biomedical Research Institute, Paris-Est Créteil University, Créteil, France.
Departement of Internal Medicine, Henri Mondor University Hospital, Assistance Publique-Hôpitaux de Paris, Paris-Est Créteil University, Créteil, France.
ORCID: 0000-0002-5736-8493

Isabelle Meyts (I)

Department of Immunology and Microbiology, Laboratory for Inborn Errors of Immunity, Department of Pediatrics, University Hospitals Leuven and Katholieke Universiteit Leuven, Leuven, Belgium.
ORCID: 0000-0003-1214-0302

Adrian Gervais (A)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Imagine Institute, University Paris Cité, Paris, France.
ORCID: 0000-0002-1083-5787

Magali Bouvier-Alias (M)

Virology, Bacteriology, Hygiene and Mycology-Parasitology, Henri Mondor University Hospital, Assistance Publique-Hôpitaux de Paris, Créteil, France.
INSERM U955, team 18. Mondor Biomedical Research Institute, Paris-Est Créteil University, Créteil, France.
ORCID: 0000-0003-1590-5980

Imane Azzaoui (I)

INSERM U955, team 2. Mondor Biomedical Research Institute, Paris-Est Créteil University, Créteil, France.
Departement of Internal Medicine, Henri Mondor University Hospital, Assistance Publique-Hôpitaux de Paris, Paris-Est Créteil University, Créteil, France.
ORCID: 0000-0001-5603-6780

Ignacio Fernández (I)

Institut Pasteur, University Paris Cité, CNRS UMR 3569, Structural Virology Unit, Paris, France.
ORCID: 0000-0003-2632-8111

Andréa de la Selle (A)

Necker Enfants Malades Institute, INSERM U1151/CNRS UMR 8253, Action thématique incitative sur programme-Avenir Team Auto-Immune and Immune B cell, University Paris Cité, University Paris-Est-Créteil, Créteil, France.
ORCID: 0000-0002-9098-0107

Qian Zhang (Q)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Imagine Institute, University Paris Cité, Paris, France.
St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.
ORCID: 0000-0002-9040-3289

Lucy Bizien (L)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Imagine Institute, University Paris Cité, Paris, France.
ORCID: 0000-0001-9163-9122

Isabelle Pellier (I)

Pediatric Immuno-hemato-oncology Unit, Centre Hospitalier Universitaire Angers, Angers, France.
University Angers, Nantes university, Centre Hospitalier Universitaire Angers, INSERM, CRCI2NA, SFR ICAT, Angers, France.
ORCID: 0000-0002-7988-4712

Agnès Linglart (A)

Departement of Pediatric Endocrinology, Bicêtre University Hospital, Assistance Publique-Hôpitaux de Paris, Paris Saclay University, Le Kremlin-Bicêtre, France.
ORCID: 0000-0003-3455-002X

Anya Rothenbuhler (A)

Departement of Pediatric Endocrinology, Bicêtre University Hospital, Assistance Publique-Hôpitaux de Paris, Paris Saclay University, Le Kremlin-Bicêtre, France.
ORCID: 0000-0001-9246-5160

Estelle Marcoux (E)

Department of Pediatrics, Nord Franche Comté Hospital, Trévenans, France.
ORCID: 0000-0003-3023-1697

Raphael Anxionnat (R)

Department of Pediatrics, Besançon Hospital, Besançon, France.
ORCID: 0000-0002-1152-7321

Nathalie Cheikh (N)

Department of Pediatrics, Besançon Hospital, Besançon, France.
ORCID: 0000-0002-3403-3842

Juliane Léger (J)

Department of Pediatric Endocrinology and INSERM NeuroDiderot, Referral Centre for Endocrine, Growth and Development diseases, Assistance Publique-Hôpitaux de Paris Nord, University of Paris, Paris, France.
ORCID: 0000-0003-3708-7341

Blanca Amador-Borrero (B)

Department of Internal Medicine, Lariboisière University Hospital, Assistance Publique-Hôpitaux de Paris, University of Paris, Paris, France.

Fanny Fouyssac (F)

Department of Pediatric Hemato-oncology, Childrens Hospital, Nancy University Hospital, Nancy, France.

Vanessa Menut (V)

Department of Pediatrics, Mother-Child Hospital, Nantes, France.
ORCID: 0000-0002-7618-8965

Jean-Christophe Goffard (JC)

Department of Internal Medicine, Université Libre de Bruxelles-Hôpitaux Universitaire de Bruxelles, Erasme Hospital, Bruxelles, Belgique.
ORCID: 0000-0002-2730-7673

Caroline Storey (C)

Departement of Pediatric Endocrinology, Robert Debré Hospital, Assistance Publique Hôpitaux de Paris, Paris, France.
ORCID: 0000-0001-8633-2118

Caroline Demily (C)

GénoPsy Referral Center, Centre de Référence de Maladies Rares Rare Disease with Psychiatric Epression, Le Vinatier Hospital, Bron, France.
ORCID: 0000-0003-3663-8447

Coralie Mallebranche (C)

Pediatric Immuno-hemato-oncology Unit, Centre Hospitalier Universitaire Angers, Angers, France.
University Angers, Nantes university, Centre Hospitalier Universitaire Angers, INSERM, CRCI2NA, SFR ICAT, Angers, France.
ORCID: 0000-0002-8385-4057

Jesus Troya (J)

Department of Internal Medicine, Infanta Leonor University Hospital, Madrid, Spain.
ORCID: 0000-0001-7323-114X

Aurora Pujol (A)

Neurometabolic Diseases Laboratory, Institut d'Investigació Biomèdica de Bellvitge-Hospital Duran i Reynals, Centro de Investigación Biomédica en Red de Enfermededas Raras U759, and Catalan Institution of Research and Advanced Studies, Barcelona, Spain.
ORCID: 0000-0002-9606-0600

Marie Zins (M)

University of Paris, University of Paris-Saclay, Université de Versailles Saint-Quentin-en-Yvelines, INSERM UMS11, Villejuif, France.
ORCID: 0000-0002-4540-4282

Pierre Tiberghien (P)

French Blood Agency, La Plaine Saint-Denis, France.
UMR1098 RIGHT, INSERM, French Blood Agency, Franche-Comté University, Besançon, France.
ORCID: 0000-0002-9310-8322

Paul E Gray (PE)

Department of Immunology and Infectious Diseases, Sydney Children's Hospital, Randwick, New South Wales, Australia.
School of Women's and Children's Health, University of New South Wales, Sydney, Australia.
Clinical Immunogenomics Research Consortium of Australasia, Sydney, Australia.
ORCID: 0000-0003-2057-3968

Peter McNaughton (P)

Clinical Immunogenomics Research Consortium of Australasia, Sydney, Australia.
Queensland Paediatric Immunology and Allergy Service, Children's Health Queensland, Brisbane, Australia.
ORCID: 0000-0002-4600-8839

Anna Sullivan (A)

Clinical Immunogenomics Research Consortium of Australasia, Sydney, Australia.
Queensland Paediatric Immunology and Allergy Service, Children's Health Queensland, Brisbane, Australia.

Jane Peake (J)

Clinical Immunogenomics Research Consortium of Australasia, Sydney, Australia.
Queensland Paediatric Immunology and Allergy Service, Children's Health Queensland, Brisbane, Australia.
University of Queensland, Brisbane, Australia.
ORCID: 0000-0001-9003-5861

Romain Levy (R)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Imagine Institute, University Paris Cité, Paris, France.
Department of Pediatric Immuno-Haematology and Rheumatology, Necker-Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
ORCID: 0000-0002-6393-0198

Laetitia Languille (L)

Departement of Internal Medicine, Henri Mondor University Hospital, Assistance Publique-Hôpitaux de Paris, Paris-Est Créteil University, Créteil, France.
ORCID: 0000-0001-8424-7550

Carlos Rodiguez-Gallego (C)

Department of Immunology, Hospital Universitario de G.C. Dr. Negrín, Canarian Health System, Las Palmas de Gran Canaria, Spain.
University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain.

Bertrand Boisson (B)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Imagine Institute, University Paris Cité, Paris, France.
St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.
ORCID: 0000-0001-5240-3555

Sébastien Gallien (S)

Department of Infectious Diseases, Henri Mondor University Hospital, Assistance Publique-Hôpitaux de Paris, Paris-Est Créteil University, Créteil, France.
ORCID: 0000-0002-8033-0936

Bénédicte Neven (B)

Department of Pediatric Immuno-Haematology and Rheumatology, Necker-Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
ORCID: 0000-0001-8941-0935

Marc Michel (M)

Departement of Internal Medicine, Henri Mondor University Hospital, Assistance Publique-Hôpitaux de Paris, Paris-Est Créteil University, Créteil, France.

Bertrand Godeau (B)

Departement of Internal Medicine, Henri Mondor University Hospital, Assistance Publique-Hôpitaux de Paris, Paris-Est Créteil University, Créteil, France.
ORCID: 0000-0002-6023-5990

Laurent Abel (L)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Imagine Institute, University Paris Cité, Paris, France.
St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.
ORCID: 0000-0001-7016-6493

Felix A Rey (FA)

Institut Pasteur, University Paris Cité, CNRS UMR 3569, Structural Virology Unit, Paris, France.
ORCID: 0000-0002-9953-7988

Jean-Claude Weill (JC)

Necker Enfants Malades Institute, INSERM U1151/CNRS UMR 8253, Action thématique incitative sur programme-Avenir Team Auto-Immune and Immune B cell, University Paris Cité, University Paris-Est-Créteil, Créteil, France.
ORCID: 0000-0002-8284-0489

Claude-Agnès Reynaud (CA)

Necker Enfants Malades Institute, INSERM U1151/CNRS UMR 8253, Action thématique incitative sur programme-Avenir Team Auto-Immune and Immune B cell, University Paris Cité, University Paris-Est-Créteil, Créteil, France.
ORCID: 0000-0002-4519-4473

Stuart G Tangye (SG)

Clinical Immunogenomics Research Consortium of Australasia, Sydney, Australia.
Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales, Australia.
St Vincent's Clinical School, Faculty of Medicine & Health, University of New South Wales, Sydney, New South Wales, Australia.
ORCID: 0000-0002-5360-5180

Jean-Laurent Casanova (JL)

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Necker Hospital for Sick Children, Paris, France.
Imagine Institute, University Paris Cité, Paris, France.
Department of Pediatrics, Necker Hospital for Sick Children, Assistance Publique-Hôpitaux de Paris, Paris, France.
St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.
Howard Hughes Medical Institute, New York, NY.
ORCID: 0000-0002-7782-4169

Matthieu Mahévas (M)

Necker Enfants Malades Institute, INSERM U1151/CNRS UMR 8253, Action thématique incitative sur programme-Avenir Team Auto-Immune and Immune B cell, University Paris Cité, University Paris-Est-Créteil, Créteil, France.
INSERM U955, team 2. Mondor Biomedical Research Institute, Paris-Est Créteil University, Créteil, France.
Departement of Internal Medicine, Henri Mondor University Hospital, Assistance Publique-Hôpitaux de Paris, Paris-Est Créteil University, Créteil, France.
ORCID: 0000-0001-9182-1434

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Human type I IFN deficiency does not impair B...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps neutralisants › Human type I IFN deficiency does not impair B...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps antiviraux › Human type I IFN deficiency does not impair B...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Autoanticorps › Human type I IFN deficiency does not impair B...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Human type I IFN deficiency does not impair B...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Human type I IFN deficiency does not impair B...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Protéines de l'enveloppe virale › Protéines de fusion virale › Glycoprotéine de spicule des coronavirus › Human type I IFN deficiency does not impair B...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs de reconnaissance de motifs moléculaires › Récepteurs de type Toll › Récepteur de type Toll-7 › Human type I IFN deficiency does not impair B...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pratiques en santé publique › Prévention primaire › Immunisation › Vaccination › Human type I IFN deficiency does not impair B...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Vaccins synthétiques › Vaccins à base d'acide nucléique › Vaccins à ARNm › Human type I IFN deficiency does not impair B...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins antiviraux › Vaccins contre la COVID-19 › Human type I IFN deficiency does not impair B...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › Human type I IFN deficiency does not impair B...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interférons › Interféron de type I › Human type I IFN deficiency does not impair B...