Assembly of Poly(vinylphosphonic acid)-Based Double Hydrophilic Block Copolymers by Gadolinium Ions for the Formation of Highly Stable MRI Contrast Agents.
Journal
ACS macro letters
ISSN: 2161-1653
Titre abrégé: ACS Macro Lett
Pays: United States
ID NLM: 101574672
Informations de publication
Date de publication:
20 12 2022
20 12 2022
Historique:
pubmed:
8
11
2022
medline:
22
12
2022
entrez:
7
11
2022
Statut:
ppublish
Résumé
Mixing double-hydrophilic block copolymers containing a poly(vinylphosphonic acid) block with gadolinium ions in water leads to the spontaneous formation of polymeric nanoparticles. With an average diameter near 20 nm, the nanoparticles are stable after dilution or change of pH and ionic strength. High magnetic relaxivities were measured in vitro, and in vivo magnetic resonance imaging on rats demonstrates the high potential of such polymeric assemblies.
Identifiants
pubmed: 36343111
doi: 10.1021/acsmacrolett.2c00489
doi:
Substances chimiques
Contrast Media
0
Gadolinium
AU0V1LM3JT
poly(vinylphosphonic acid)
0
Polymers
0
vinylphosphonic acid
1746-03-8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM