A data-informed approach using individualised dispensing patterns to estimate medicine exposure periods and dose from pharmaceutical claims data.
drug utilization
methods
pharmacoepidemiology
treatment episodes
Journal
Pharmacoepidemiology and drug safety
ISSN: 1099-1557
Titre abrégé: Pharmacoepidemiol Drug Saf
Pays: England
ID NLM: 9208369
Informations de publication
Date de publication:
03 2023
03 2023
Historique:
revised:
28
10
2022
received:
18
01
2022
accepted:
04
11
2022
pubmed:
9
11
2022
medline:
17
2
2023
entrez:
8
11
2022
Statut:
ppublish
Résumé
Pharmaceutical claims data are often used as the primary information source to define medicine exposure periods in pharmacoepidemiological studies. However, often critical information on directions for use and the intended duration of medicine supply are not available. In the absence of this information, alternative approaches are needed to support the assignment of exposure periods. This study summarises the key methods commonly used to estimate medicine exposure periods and dose from pharmaceutical claims data; and describes a method using individualised dispensing patterns to define time-dependent estimates of medicine exposure and dose. This method extends on important features of existing methods and also accounts for recent changes in an individual's medicine use. Specifically, this method constructs medicine exposure periods and estimates the dose used by considering characteristics from an individual's prior dispensings, accounting for the time between prior dispensings and the amount supplied at prior dispensings. Guidance on the practical applications of this method is also provided. Although developed primarily for application to databases, which do not contain duration of supply or dose information, use of this method may also facilitate investigations when such information is available and there is a need to consider individualised and/or changing dosing regimens. By shifting the reliance on prescribed duration and dose to determine exposure and dose estimates, individualised dispensing information is used to estimate patterns of exposure and dose for an individual. Reflecting real-world individualised use of medicines with complex and variable dosing regimens, this method offers a pragmatic approach that can be applied to all medicine classes.
Substances chimiques
Pharmaceutical Preparations
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
352-365Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2022 The Authors. Pharmacoepidemiology and Drug Safety published by John Wiley & Sons Ltd.
Références
Pharmacoepidemiol Drug Saf. 2020 Sep;29(9):1141-1150
pubmed: 32394589
Pharmacoepidemiol Drug Saf. 2016 Jun;25(6):733-7
pubmed: 26693665
Pharmacoepidemiol Drug Saf. 2023 Mar;32(3):352-365
pubmed: 36345837
Pharmacoepidemiol Drug Saf. 2015 Oct;24(10):1117-9
pubmed: 26428551
Basic Clin Pharmacol Toxicol. 2010 Feb;106(2):86-94
pubmed: 19961477
Pharmacoepidemiol Drug Saf. 2017 Sep;26(9):1018-1032
pubmed: 28913963
Pharmacoepidemiol Drug Saf. 2017 Dec;26(12):1520-1526
pubmed: 29024218
BMJ. 2016 Oct 20;355:i5340
pubmed: 27797785
BMJ Open. 2018 Dec 4;8(12):e025840
pubmed: 30518593
Pharmacoepidemiol Drug Saf. 2019 Feb;28(2):156-170
pubmed: 30022560
Eur J Clin Pharmacol. 2012 Dec;68(12):1631-7
pubmed: 22576729
J Clin Epidemiol. 2016 Jan;69:107-13
pubmed: 26146090
J Clin Epidemiol. 2018 Feb;94:132-142
pubmed: 29097340
J Multidiscip Healthc. 2016 May 04;9:211-7
pubmed: 27217764
Pharmacoepidemiol Drug Saf. 2017 Aug;26(8):909-916
pubmed: 28474439
BMJ. 2016 Mar 30;352:i1541
pubmed: 27029385
Pharmacoepidemiol Drug Saf. 2020 Sep;29(9):1101-1110
pubmed: 32783283
J Clin Epidemiol. 2006 Apr;59(4):393-403
pubmed: 16549262
Clin Epidemiol. 2016 Oct 11;8:363-371
pubmed: 27785101
BMC Res Notes. 2015 Nov 02;8:634
pubmed: 26526064
Pharmacoepidemiol Drug Saf. 2019 Nov;28(11):1448-1456
pubmed: 31418512
Pharmacoepidemiol Drug Saf. 2020 Aug;29(8):939-950
pubmed: 32662222
Pharmacoepidemiol Drug Saf. 2018 Sep;27(9):1011-1018
pubmed: 29952049
Pharmacoepidemiol Drug Saf. 2017 Aug;26(8):900-908
pubmed: 28466973
BMJ. 2018 Nov 14;363:k3532
pubmed: 30429167
Pharmacoepidemiol Drug Saf. 2016 Dec;25(12):1434-1442
pubmed: 27633276
BMC Med Inform Decis Mak. 2015 Mar 25;15:21
pubmed: 25890003
Int Psychogeriatr. 2012 Apr;24(4):577-86
pubmed: 22059800
Pharmacoepidemiol Drug Saf. 2022 Jan;31(1):55-60
pubmed: 34611960
Pharmacoepidemiol Drug Saf. 2013 Aug;22(8):803-9
pubmed: 23703741
Int J Cardiol. 2016 Oct 1;220:668-76
pubmed: 27393848
BMJ. 2015 Jun 10;350:h2698
pubmed: 26063215
Eur J Pain. 2019 May;23(5):908-922
pubmed: 30620116