Kidney function measures and cardiovascular outcomes in people with diabetes: the Hoorn Diabetes Care System cohort.
Cardiovascular disease
Diabetes
Kidney function
Time-dependent Cox regression
Journal
Diabetologia
ISSN: 1432-0428
Titre abrégé: Diabetologia
Pays: Germany
ID NLM: 0006777
Informations de publication
Date de publication:
03 2023
03 2023
Historique:
received:
30
06
2022
accepted:
20
09
2022
pubmed:
9
11
2022
medline:
4
2
2023
entrez:
8
11
2022
Statut:
ppublish
Résumé
Both manifestations of kidney disease in diabetes, reduced eGFR (ml/min per 1.73 m We assessed the prospective association between annually recorded measures of eGFR and UACR and the occurrence of myocardial infarction (MI), CHD, stroke, heart failure (HF) and cardiovascular mortality in 13,657 individuals with diabetes (53.6% male, age 62.3±12.1 years) from the Hoorn Diabetes Care System cohort, using data obtained between 1998 and 2018. Multivariate time-dependent Cox regression models adjusted for cardiovascular risk factors were used to estimate HRs and 95% CI. Associations of eGFR were adjusted for UACR values and vice versa. Effect modification by sex was investigated for all associations. After a mean follow-up period of 7 years, event rates per 1000 person-years were 3.08 for MI, 3.72 for CHD, 1.12 for HF, 0.84 for stroke and 6.25 for cardiovascular mortality. Mildly reduced eGFR (60-90 ml/min per 1.73 m This study showed differential and independent prospective associations between manifestations of early kidney damage in diabetes and several CVD subtypes, suggesting that regular monitoring of both kidney function measures may help to identify individuals at higher risk of specific cardiovascular events.
Identifiants
pubmed: 36347992
doi: 10.1007/s00125-022-05826-y
pii: 10.1007/s00125-022-05826-y
pmc: PMC9892144
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
482-494Subventions
Organisme : Hartstichting
ID : 30982441
Organisme : ZonMw
ID : 9171 8304
Pays : Netherlands
Informations de copyright
© 2022. The Author(s).
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