Leveraging Accelerometry as a Prognostic Indicator for Increase in Opioid Withdrawal Symptoms.
accelerometer
non-invasive therapies
opioid addiction
opioid use disorder
opioid withdrawal
restlessness
spectral analysis
spectrograms
vagal nerve stimulation
wearable
Journal
Biosensors
ISSN: 2079-6374
Titre abrégé: Biosensors (Basel)
Pays: Switzerland
ID NLM: 101609191
Informations de publication
Date de publication:
26 Oct 2022
26 Oct 2022
Historique:
received:
30
08
2022
revised:
14
10
2022
accepted:
21
10
2022
entrez:
10
11
2022
pubmed:
11
11
2022
medline:
15
11
2022
Statut:
epublish
Résumé
Treating opioid use disorder (OUD) is a significant healthcare challenge in the United States. Remaining abstinent from opioids is challenging for individuals with OUD due to withdrawal symptoms that include restlessness. However, to our knowledge, studies of acute withdrawal have not quantified restlessness using involuntary movements. We hypothesized that wearable accelerometry placed mid-sternum could be used to detect withdrawal-related restlessness in patients with OUD. To study this, 23 patients with OUD undergoing active withdrawal participated in a protocol involving wearable accelerometry, opioid cues to elicit craving, and non-invasive Vagal Nerve Stimulation (nVNS) to dampen withdrawal symptoms. Using accelerometry signals, we analyzed how movements correlated with changes in acute withdrawal severity, measured by the Clinical Opioid Withdrawal Scale (COWS). Our results revealed that patients demonstrating sinusoidal-i.e., predominantly single-frequency oscillation patterns in their motion almost exclusively demonstrated an increase in the COWS, and a strong relationship between the maximum power spectral density and increased withdrawal over time, measured by the COWS (R = 0.92,
Identifiants
pubmed: 36354433
pii: bios12110924
doi: 10.3390/bios12110924
pmc: PMC9688173
pii:
doi:
Substances chimiques
Analgesics, Opioid
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : RRD VA
ID : I01 RX003418
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH056120
Pays : United States
Organisme : NIDA NIH HHS
ID : UG3 DA048502-01A1S1
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH120262
Pays : United States
Organisme : National Science Foundation
ID : DGE-2039655
Organisme : NIDA NIH HHS
ID : UG3 DA048502
Pays : United States
Organisme : NIMH NIH HHS
ID : K24 MH076955
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL088726
Pays : United States
Organisme : NIDA NIH HHS
ID : UG3 DA048502-01A1S2
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL101398
Pays : United States
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