Association of - 717 A > G (rs2794521) CRP polymorphism with high cardiovascular risk by C-reactive protein in systemic lupus erythematosus patients.

Humans Female Genetic Predisposition to Disease C-Reactive Protein / metabolism Cardiovascular Diseases / etiology Cross-Sectional Studies Risk Factors Genotype Polymorphism, Single Nucleotide Heart Disease Risk Factors Lupus Erythematosus, Systemic / complications Gene Frequency Case-Control Studies
C-reactive protein CRP polymorphism Cardiovascular risk Systemic lupus erythematosus

Journal

Clinical rheumatology
ISSN: 1434-9949
Titre abrégé: Clin Rheumatol
Pays: Germany
ID NLM: 8211469

Informations de publication

Date de publication:
Mar 2023
Historique:
received: 10 05 2022
accepted: 28 10 2022
revised: 07 10 2022
pubmed: 11 11 2022
medline: 22 2 2023
entrez: 10 11 2022
Statut: ppublish

Résumé

Systemic lupus erythematosus (SLE) is an autoimmune disease where genetic factors have been related to SLE susceptibility and disease severity. CRP polymorphisms have been associated with high C-reactive protein (CRP) serum levels, cardiovascular disease (CVD), and high clinical disease activity in SLE patients; however, the evidence is still inconclusive. This study was aimed to assess the association of the - 717 A > G, - 409 G > A, + 1444 C > T, and + 1846 C > T CRP polymorphisms with genetic susceptibility, clinical disease activity, and CVD risk in Mexican-mestizo SLE patients. A comparative cross-sectional study was conducted on 369 unrelated women: 183 with SLE according to the 1997 SLE-ACR criteria and 186 healthy subjects (HS). The clinical disease activity was assessed by the Mex-SLEDAI score; CRP and lipid profile were quantified by turbidimetry and colorimetric-enzymatic assays, respectively. The CRP polymorphisms genotyping was carried out by allelic discrimination. SLE patients with - 717 AA genotype had higher CRP serum levels than SLE carriers of AG and GG genotypes (AA = 5 mg/L vs. AG = 3.2 mg/L vs. GG = 2.4 mg/L; p = 0.01), and the AA genotype was associated with high CVD risk by CRP in SLE patients (OR = 3; CI: 1.2-7.6; p < 0.01). The - 717 A > G CRP polymorphism is a risk factor for high CRP levels and high CVD risk in Mexican-mestizo SLE patients. Key Points • Cardiovascular disease is one of the major causes of death in SLE patients due to the higher prevalence of traditional and non-traditional cardiovascular risk factors. • C-reactive protein is a liver-derived acute-phase protein suggested as one powerful independent risk predictor factor for cardiovascular disease. • Single nucleotide polymorphisms in CRP have been suggested as genetic susceptibility factors that could modify the SLE pathophysiology outcomes. • Mexican-mestizo SLE patients carrying the -717 A>G CRP AA genotype had 3-fold high cardiovascular disease risk than SLE patients with AG or GG genotypes.

Identifiants

DOI: 10.1007/s10067-022-06430-6 PMID: 36355253
pubmed: 36355253
doi: 10.1007/s10067-022-06430-6
pii: 10.1007/s10067-022-06430-6
doi:

Substances chimiques

C-Reactive Protein 9007-41-4

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

761-772

Informations de copyright

© 2022. The Author(s), under exclusive licence to International League of Associations for Rheumatology (ILAR).

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Auteurs

Karen Pesqueda-Cendejas (K)

Red de Inmunonutrición Y Genómica Nutricional en Las Enfermedades Autoinmunes, Centro Universitario de Ciencias de La Salud, Universidad de Guadalajara, 44340, Guadalajara, Jalisco, Mexico.
Instituto de Neurociencias Traslacionales, Departamento de Neurociencias, Centro Universitario de Ciencias de La Salud, Universidad de Guadalajara, 44340, Guadalajara, Jalisco, Mexico.
ORCID: 0000-0002-6849-5965

Isela Parra-Rojas (I)

Red de Inmunonutrición Y Genómica Nutricional en Las Enfermedades Autoinmunes, Centro Universitario de Ciencias de La Salud, Universidad de Guadalajara, 44340, Guadalajara, Jalisco, Mexico.
Laboratorio de Investigación en Obesidad Y Diabetes, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, 39087, Chilpancingo de los Bravo, Guerrero, Mexico.
ORCID: 0000-0002-9213-8263

Mónica R Meza-Meza (MR)

Red de Inmunonutrición Y Genómica Nutricional en Las Enfermedades Autoinmunes, Centro Universitario de Ciencias de La Salud, Universidad de Guadalajara, 44340, Guadalajara, Jalisco, Mexico.
Instituto de Neurociencias Traslacionales, Departamento de Neurociencias, Centro Universitario de Ciencias de La Salud, Universidad de Guadalajara, 44340, Guadalajara, Jalisco, Mexico.
ORCID: 0000-0003-4991-4965

Paulina E Mora-García (PE)

Red de Inmunonutrición Y Genómica Nutricional en Las Enfermedades Autoinmunes, Centro Universitario de Ciencias de La Salud, Universidad de Guadalajara, 44340, Guadalajara, Jalisco, Mexico.
Instituto de Neurociencias Traslacionales, Departamento de Neurociencias, Centro Universitario de Ciencias de La Salud, Universidad de Guadalajara, 44340, Guadalajara, Jalisco, Mexico.
ORCID: 0000-0002-5452-6222

Bertha Campos-López (B)

Red de Inmunonutrición Y Genómica Nutricional en Las Enfermedades Autoinmunes, Centro Universitario de Ciencias de La Salud, Universidad de Guadalajara, 44340, Guadalajara, Jalisco, Mexico.
Instituto de Neurociencias Traslacionales, Departamento de Neurociencias, Centro Universitario de Ciencias de La Salud, Universidad de Guadalajara, 44340, Guadalajara, Jalisco, Mexico.
ORCID: 0000-0002-1667-8794

Adolfo I Ruiz-Ballesteros (AI)

Red de Inmunonutrición Y Genómica Nutricional en Las Enfermedades Autoinmunes, Centro Universitario de Ciencias de La Salud, Universidad de Guadalajara, 44340, Guadalajara, Jalisco, Mexico.
Instituto de Neurociencias Traslacionales, Departamento de Neurociencias, Centro Universitario de Ciencias de La Salud, Universidad de Guadalajara, 44340, Guadalajara, Jalisco, Mexico.
ORCID: 0000-0001-8993-6312

Margarita Montoya-Buelna (M)

Red de Inmunonutrición Y Genómica Nutricional en Las Enfermedades Autoinmunes, Centro Universitario de Ciencias de La Salud, Universidad de Guadalajara, 44340, Guadalajara, Jalisco, Mexico.
Laboratorio de Inmunología, Departamento de Fisiología, Centro Universitario de Ciencias de La Salud, Universidad de Guadalajara, 44340, Guadalajara, Jalisco, Mexico.
ORCID: 0000-0001-9309-1957

Melissa Rivera-Escoto (M)

Red de Inmunonutrición Y Genómica Nutricional en Las Enfermedades Autoinmunes, Centro Universitario de Ciencias de La Salud, Universidad de Guadalajara, 44340, Guadalajara, Jalisco, Mexico.
Instituto de Neurociencias Traslacionales, Departamento de Neurociencias, Centro Universitario de Ciencias de La Salud, Universidad de Guadalajara, 44340, Guadalajara, Jalisco, Mexico.
ORCID: 0000-0001-9069-7478

José M Moreno-Ortiz (JM)

Instituto de Genética Humana "Dr. Enrique Corona Rivera, Departamento de Biología Molecular Y Genómica, Centro Universitario de Ciencias de La Salud, Universidad de Guadalajara, 44340, Guadalajara, Jalisco, Mexico.
ORCID: 0000-0001-7555-9851

Luis A Bautista-Herrera (LA)

Departamento de Farmacobiología, Centro Universitario de Ciencias Exactas E Ingenierías, Universidad de Guadalajara, 44430, Guadalajara, Jalisco, Mexico.
ORCID: 0000-0002-3599-3909

Sergio Cerpa-Cruz (S)

Departamento de Reumatología, O.P.D. Hospital Civil de Guadalajara Fray Antonio Alcalde, 44280, Guadalajara, Jalisco, Mexico.
ORCID: 0000-0002-0755-0289

Ulises De la Cruz-Mosso (U)

Red de Inmunonutrición Y Genómica Nutricional en Las Enfermedades Autoinmunes, Centro Universitario de Ciencias de La Salud, Universidad de Guadalajara, 44340, Guadalajara, Jalisco, Mexico. ulises_cdm@hotmail.com.
Instituto de Neurociencias Traslacionales, Departamento de Neurociencias, Centro Universitario de Ciencias de La Salud, Universidad de Guadalajara, 44340, Guadalajara, Jalisco, Mexico. ulises_cdm@hotmail.com.
ORCID: 0000-0003-4579-2294

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Association of - 717 A > G (rs2794521) CRP...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Association of - 717 A > G (rs2794521) CRP...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Immunoprotéines › Protéine C-réactive › Association of - 717 A > G (rs2794521) CRP...
questionsmedicales.fr › Maladies cardiovasculaires › Association of - 717 A > G (rs2794521) CRP...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Association of - 717 A > G (rs2794521) CRP...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Association of - 717 A > G (rs2794521) CRP...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Association of - 717 A > G (rs2794521) CRP...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Association of - 717 A > G (rs2794521) CRP...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Facteurs de risque de maladie cardiaque › Association of - 717 A > G (rs2794521) CRP...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Lupus érythémateux disséminé › Association of - 717 A > G (rs2794521) CRP...
questionsmedicales.fr › Phénomènes génétiques › Fréquence d'allèle › Association of - 717 A > G (rs2794521) CRP...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Association of - 717 A > G (rs2794521) CRP...