Genome-microbiome interplay provides insight into the determinants of the human blood metabolome.
Journal
Nature metabolism
ISSN: 2522-5812
Titre abrégé: Nat Metab
Pays: Germany
ID NLM: 101736592
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
received:
07
02
2022
accepted:
30
09
2022
pubmed:
11
11
2022
medline:
26
11
2022
entrez:
10
11
2022
Statut:
ppublish
Résumé
Variation in the blood metabolome is intimately related to human health. However, few details are known about the interplay between genetics and the microbiome in explaining this variation on a metabolite-by-metabolite level. Here, we perform analyses of variance for each of 930 blood metabolites robustly detected across a cohort of 1,569 individuals with paired genomic and microbiome data while controlling for a number of relevant covariates. We find that 595 (64%) of these blood metabolites are significantly associated with either host genetics or the gut microbiome, with 69% of these associations driven solely by the microbiome, 15% driven solely by genetics and 16% under hybrid genome-microbiome control. Additionally, interaction effects, where a metabolite-microbe association is specific to a particular genetic background, are quite common, albeit with modest effect sizes. This knowledge will help to guide targeted interventions designed to alter the composition of the human blood metabolome.
Identifiants
pubmed: 36357685
doi: 10.1038/s42255-022-00670-1
pii: 10.1038/s42255-022-00670-1
pmc: PMC9691620
mid: NIHMS1845232
doi:
Substances chimiques
RNA, Ribosomal, 16S
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1560-1572Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK133468
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG023122
Pays : United States
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature Limited.
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