Druggable Metabolic Vulnerabilities Are Exposed and Masked during Progression to Castration Resistant Prostate Cancer.
Warburg’s effect
androgen receptor
cancer metabolism
drug resistance
fatty acids
lactate
prostate cancer
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
28 10 2022
28 10 2022
Historique:
received:
04
10
2022
revised:
26
10
2022
accepted:
27
10
2022
entrez:
11
11
2022
pubmed:
12
11
2022
medline:
15
11
2022
Statut:
epublish
Résumé
There is an urgent need for exploring new actionable targets other than androgen receptor to improve outcome from lethal castration-resistant prostate cancer. Tumor metabolism has reemerged as a hallmark of cancer that drives and supports oncogenesis. In this regard, it is important to understand the relationship between distinctive metabolic features, androgen receptor signaling, genetic drivers in prostate cancer, and the tumor microenvironment (symbiotic and competitive metabolic interactions) to identify metabolic vulnerabilities. We explore the links between metabolism and gene regulation, and thus the unique metabolic signatures that define the malignant phenotypes at given stages of prostate tumor progression. We also provide an overview of current metabolism-based pharmacological strategies to be developed or repurposed for metabolism-based therapeutics for castration-resistant prostate cancer.
Identifiants
pubmed: 36358940
pii: biom12111590
doi: 10.3390/biom12111590
pmc: PMC9687810
pii:
doi:
Substances chimiques
Receptors, Androgen
0
Types de publication
Journal Article
Review
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : R21CA255830
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA097186
Pays : United States
Organisme : NCI NIH HHS
ID : P50CA211024
Pays : United States
Organisme : CIHR
ID : PJT-180554
Pays : Canada
Références
Cancers (Basel). 2021 Aug 20;13(16):
pubmed: 34439338
Nat Rev Urol. 2013 Apr;10(4):219-26
pubmed: 23478540
Biochim Biophys Acta Mol Basis Dis. 2020 May 1;1866(5):165720
pubmed: 32057943
J Gen Physiol. 1927 Mar 7;8(6):519-30
pubmed: 19872213
Nat Rev Mol Cell Biol. 2014 Aug;15(8):536-50
pubmed: 25053359
Database (Oxford). 2021 Apr 7;2021:
pubmed: 33826699
Sci Rep. 2022 Apr 22;12(1):6660
pubmed: 35459777
Cold Spring Harb Perspect Med. 2018 Oct 1;8(10):
pubmed: 29229664
J Clin Invest. 2021 Feb 15;131(4):
pubmed: 33320840
Br J Clin Pharmacol. 2015 Mar;79(3):465-76
pubmed: 25223731
Blood. 2007 May 1;109(9):3812-9
pubmed: 17255361
Front Oncol. 2020 Oct 09;10:580617
pubmed: 33163409
Cell. 2015 Sep 10;162(6):1229-41
pubmed: 26321679
EBioMedicine. 2016 May;7:50-61
pubmed: 27322458
N Engl J Med. 1995 May 25;332(21):1393-8
pubmed: 7723794
Genes Dev. 2016 Nov 1;30(21):2345-2369
pubmed: 27881599
Mol Cancer. 2005 Sep 09;4:32
pubmed: 16153295
Prostate Cancer Prostatic Dis. 2021 Sep;24(3):697-717
pubmed: 33820953
PLoS One. 2018 Sep 14;13(9):e0203745
pubmed: 30216369
Science. 1928 Nov 9;68(1767):437-43
pubmed: 17782077
J Steroid Biochem Mol Biol. 2004 Nov;92(4):273-9
pubmed: 15663990
Front Oncol. 2020 Nov 05;10:594782
pubmed: 33251150
Sci Adv. 2022 Feb 18;8(7):eabl4923
pubmed: 35171681
Genes (Basel). 2022 Feb 18;13(2):
pubmed: 35205419
Cancer Res. 2022 Mar 01;82(5):831-845
pubmed: 34965937
Br J Cancer. 2020 Jan;122(2):150-156
pubmed: 31819187
Mol Cancer Ther. 2014 Apr;13(4):855-66
pubmed: 24493696
Cell Chem Biol. 2016 Jun 23;23(6):678-88
pubmed: 27265747
Urol Oncol. 2015 Aug;33(8):338.e9-17
pubmed: 26066969
Cell Metab. 2018 May 01;27(5):947-949
pubmed: 29719230
Cancer Immunol Res. 2020 Nov;8(11):1440-1451
pubmed: 32917658
Cell Rep. 2022 Jun 28;39(13):111010
pubmed: 35767960
Mol Cancer Ther. 2014 Apr;13(4):890-901
pubmed: 24523301
Trends Biochem Sci. 2018 Jan;43(1):61-74
pubmed: 29174173
Nat Genet. 2018 Feb;50(2):219-228
pubmed: 29335542
Nature. 2017 Jul 6;547(7661):109-113
pubmed: 28658205
Ann N Y Acad Sci. 2016 Jan;1363:91-8
pubmed: 26647078
EJNMMI Res. 2020 Nov 25;10(1):143
pubmed: 33237350
Cold Spring Harb Symp Quant Biol. 2011;76:211-6
pubmed: 22096029
Front Immunol. 2019 Oct 04;10:2309
pubmed: 31636636
Biochem Biophys Res Commun. 2018 Feb 5;496(2):726-730
pubmed: 29357281
Biochem J. 2011 Jan 1;433(1):225-33
pubmed: 20958264
Nature. 2021 Mar;591(7851):645-651
pubmed: 33589820
Trends Genet. 2021 Nov;37(11):1012-1027
pubmed: 34120771
Anticancer Res. 2021 Dec;41(12):5913-5918
pubmed: 34848445
Trends Cancer. 2021 Feb;7(2):112-121
pubmed: 33274720
Sci Rep. 2015 Nov 24;5:17206
pubmed: 26598224
Science. 2017 Mar 17;355(6330):1152-1158
pubmed: 28302823
Nat Cell Biol. 2018 Jul;20(7):745-754
pubmed: 29950572
Sci Transl Med. 2019 Feb 6;11(478):
pubmed: 30728288
Cell. 2008 Sep 5;134(5):703-7
pubmed: 18775299
J Immunother Cancer. 2016 Feb 16;4:4
pubmed: 26885366
J Zhejiang Univ Sci B. 2008 Jun;9(6):441-7
pubmed: 18543396
Clin Nucl Med. 2011 Mar;36(3):192-8
pubmed: 21285676
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
BJU Int. 2004 Feb;93(3):275-8
pubmed: 14764122
J Cell Physiol. 2010 Aug;224(2):491-500
pubmed: 20432447
Oncogene. 2022 Feb;41(8):1140-1154
pubmed: 35046532
Expert Opin Ther Targets. 2017 Nov;21(11):1001-1016
pubmed: 28922023
Cancer Res. 2012 Mar 15;72(6):1494-503
pubmed: 22266222
Nat Rev Drug Discov. 2021 Jul;20(7):551-569
pubmed: 34002056
Oncologist. 2016 Dec;21(12):1427-1435
pubmed: 27628492
Oncogene. 2019 May;38(19):3681-3695
pubmed: 30664688
Cancer Lett. 2021 Mar 1;500:75-86
pubmed: 33347908
Clin Exp Immunol. 2019 Aug;197(2):161-169
pubmed: 30868561
Nat Commun. 2016 Jan 12;7:10230
pubmed: 26756352
Cancer Metab. 2014 Mar 10;2(1):4
pubmed: 24612826
Biomolecules. 2019 Dec 18;10(1):
pubmed: 31861280
Cancer Cell. 2021 Feb 8;39(2):209-224.e11
pubmed: 33450196
Cell Stem Cell. 2016 Jul 7;19(1):23-37
pubmed: 27374788
Cell Rep. 2019 Dec 10;29(11):3405-3420.e5
pubmed: 31825825
World J Surg Oncol. 2008 Jun 19;6:64
pubmed: 18565231
J Exp Clin Cancer Res. 2018 Sep 21;37(1):234
pubmed: 30241549
Prostate Cancer Prostatic Dis. 2021 Nov 22;:
pubmed: 34811499
Front Oncol. 2020 Dec 15;10:583217
pubmed: 33384955
BMC Cancer. 2014 Mar 05;14:154
pubmed: 24597899
Oncol Rev. 2019 Jul 22;13(2):403
pubmed: 31410246
Blood. 2006 Mar 1;107(5):2013-21
pubmed: 16278308
Comput Math Methods Med. 2022 Feb 22;2022:9273559
pubmed: 35242214
Front Oncol. 2019 Nov 01;9:1143
pubmed: 31737570
Oncogene. 2019 Jan;38(1):17-32
pubmed: 30072740
Nat Rev Drug Discov. 2006 Sep;5(9):769-84
pubmed: 16955068
Cell. 2022 Jul 21;185(15):2678-2689
pubmed: 35839759
Cell Metab. 2019 Jan 8;29(1):174-182.e5
pubmed: 30244972
Nat Commun. 2019 Jun 14;10(1):2625
pubmed: 31201299
Mol Cancer Res. 2003 Aug;1(10):707-15
pubmed: 12939396
Gastroenterology. 2014 Jun;146(7):1763-74
pubmed: 24657625
BJU Int. 2003 Jul;92(1):24-7
pubmed: 12823377
Lancet. 2021 Sep 18;398(10305):1075-1090
pubmed: 34370973
Biochim Biophys Acta Rev Cancer. 2019 Apr;1871(2):248-258
pubmed: 30708041
Front Immunol. 2021 Jun 10;12:688910
pubmed: 34177945
Curr Opin Cell Biol. 2017 Oct;48:47-53
pubmed: 28605656
Cancer Metab. 2021 Jan 7;9(1):2
pubmed: 33413672
Cancer Res. 1997 Mar 15;57(6):1086-90
pubmed: 9067276
Neuro Oncol. 2018 Jun 18;20(7):865-867
pubmed: 29924369
Cancer. 1996 Feb 1;77(3):474-82
pubmed: 8630954
Cancer Cell. 2010 Jul 13;18(1):11-22
pubmed: 20579941
Nature. 2009 Feb 12;457(7231):910-4
pubmed: 19212411
Nature. 2020 Mar;579(7800):507-517
pubmed: 32214253
J Steroid Biochem Mol Biol. 2017 Feb;166:1-15
pubmed: 27117390
Biomed Res Int. 2015;2015:242437
pubmed: 26779534
Sci Transl Med. 2015 Aug 26;7(302):302ra136
pubmed: 26311731
Front Immunol. 2021 Jul 29;12:691134
pubmed: 34394085
Br J Cancer. 2020 Apr;122(8):1141-1145
pubmed: 32076124
Br J Cancer. 2020 Mar;122(6):895-903
pubmed: 31937921
Trends Endocrinol Metab. 2021 Jun;32(6):367-381
pubmed: 33795176
Cancer Res. 2021 Jul 1;81(13):3664-3678
pubmed: 33985973
Clin Cancer Res. 2019 Dec 1;25(23):6916-6924
pubmed: 31363002
Cancer Res. 2010 Oct 15;70(20):8117-26
pubmed: 20876798
Oncogene. 2015 Apr 2;34(14):1745-57
pubmed: 24837363
Prostate. 2014 Aug;74(11):1153-9
pubmed: 24913988
Nature. 2019 Oct;574(7779):492-493
pubmed: 31645737
Clin Cancer Res. 2014 Feb 15;20(4):791-8
pubmed: 24305618
BMC Cancer. 2021 Oct 17;21(1):1112
pubmed: 34657603
J Androl. 2006 Mar-Apr;27(2):233-9
pubmed: 16278369
Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11818-23
pubmed: 22752304
Inflammopharmacology. 2009 Apr;17(2):55-67
pubmed: 19340409
Cancer Res. 2019 May 15;79(10):2748-2760
pubmed: 30885978
J Natl Cancer Inst. 1958 Sep;21(3):485-94
pubmed: 13576102
Discov Oncol. 2021 Oct 27;12(1):45
pubmed: 35201488
Theranostics. 2019 Jul 9;9(18):5359-5373
pubmed: 31410220
Br J Cancer. 2020 Jan;122(1):30-44
pubmed: 31819194
Clin Cancer Res. 2016 Jun 1;22(11):2721-33
pubmed: 26755530
Cell. 2017 Feb 9;168(4):657-669
pubmed: 28187287
Nat Rev Mol Cell Biol. 2019 Oct;20(10):590-607
pubmed: 31399642
CA Cancer J Clin. 2022 Jan;72(1):7-33
pubmed: 35020204
Am J Pathol. 2016 Dec;186(12):3131-3145
pubmed: 27770613
Nat Chem Biol. 2012 Oct;8(10):839-47
pubmed: 22922757
Cancer Res. 1996 Jun 15;56(12):2745-7
pubmed: 8665507
Cell Chem Biol. 2017 Sep 21;24(9):1161-1180
pubmed: 28938091
Cancer Res. 1997 Jan 15;57(2):314-9
pubmed: 9000575
Sci Adv. 2022 Jan 21;8(3):eabi6696
pubmed: 35044827
J Chem Inf Model. 2018 Aug 27;58(8):1533-1543
pubmed: 30063345
Nat Rev Drug Discov. 2022 Feb;21(2):141-162
pubmed: 34862480
Theranostics. 2021 Jun 26;11(16):7844-7868
pubmed: 34335968
Nat Commun. 2019 May 9;10(1):2123
pubmed: 31073180
J Urol. 2007 Sep;178(3 Pt 1):844-8; discussion 848
pubmed: 17631339
Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):E2772-81
pubmed: 23840057
Int J Mol Sci. 2016 Jul 27;17(8):
pubmed: 27472325
Int J Oncol. 2022 Apr;60(4):
pubmed: 35191516
Mol Cell. 2020 Jun 18;78(6):1019-1033
pubmed: 32559423
Front Oncol. 2022 Jan 21;11:778761
pubmed: 35127483
Clin Cancer Res. 2018 Jul 1;24(13):3137-3148
pubmed: 29599412
J Pathol. 2013 Aug;230(4):350-5
pubmed: 23729358
J Exp Med. 2011 Feb 14;208(2):313-26
pubmed: 21242296
Cell Death Discov. 2020 Oct 14;6:104
pubmed: 33083024
Cancer. 2001 Feb 15;91(4):737-43
pubmed: 11241241
J Nucl Med. 2011 Jan;52(1):81-9
pubmed: 21149473
Front Oncol. 2019 May 17;9:417
pubmed: 31165048
Mol Cancer Ther. 2021 Mar;20(3):467-476
pubmed: 33298590
N Engl J Med. 2021 Sep 16;385(12):1091-1103
pubmed: 34161051
J Nucl Med. 2008 Feb;49(2):327-34
pubmed: 18199615
Clin Transl Med. 2022 Mar;12(3):e764
pubmed: 35343073
Prostate. 2005 Jun 1;63(4):316-23
pubmed: 15599942
Nat Rev Drug Discov. 2011 Jun 24;10(7):507-19
pubmed: 21701501
Annu Rev Biomed Eng. 2017 Jun 21;19:163-194
pubmed: 28301735
Cureus. 2020 Jun 30;12(6):e8921
pubmed: 32760622
ACS Cent Sci. 2020 Jun 24;6(6):939-949
pubmed: 32607441
Clin Cancer Res. 2001 May;7(5):1273-81
pubmed: 11350894
Nat Rev Cancer. 2015 Dec;15(12):701-11
pubmed: 26563462
Exp Mol Med. 2021 May;53(5):788-808
pubmed: 34006904
J Immunol. 2010 Feb 1;184(3):1200-9
pubmed: 20026743
Cancer Metab. 2020 Jun 19;8:11
pubmed: 32577235
EMBO J. 2011 May 20;30(13):2719-33
pubmed: 21602788
Cancer Res. 2019 Dec 1;79(23):5907-5914
pubmed: 31434645
Nat Med. 2017 Jan;23(1):120-127
pubmed: 27869804
Front Oncol. 2020 Sep 29;10:544288
pubmed: 33117682
Genomics Proteomics Bioinformatics. 2022 Mar 9;:
pubmed: 35278714
J Med Chem. 2004 Mar 25;47(7):1739-49
pubmed: 15027865
Cell. 2015 Jul 30;162(3):540-51
pubmed: 26232224
Nat Genet. 2020 Aug;52(8):778-789
pubmed: 32661416
Hum Pathol. 1996 Sep;27(9):917-21
pubmed: 8816886
Cell Metab. 2017 Jun 6;25(6):1282-1293.e7
pubmed: 28416194
Front Immunol. 2019 Jul 03;10:1462
pubmed: 31333642
Mol Cancer Res. 2019 May;17(5):1155-1165
pubmed: 30745465
Mol Cancer Ther. 2012 Aug;11(8):1672-82
pubmed: 22689530
Cell Metab. 2020 Feb 4;31(2):284-300.e7
pubmed: 31813825
Am J Med Sci. 2019 Dec;358(6):412-421
pubmed: 31813468
Br J Cancer. 2019 Oct;121(7):556-566
pubmed: 31417189
Biochem J. 1995 Dec 1;312 ( Pt 2):479-84
pubmed: 8526859
Cell Chem Biol. 2020 Aug 20;27(8):953-969
pubmed: 32698016
Nat Rev Mol Cell Biol. 2019 Mar;20(3):137-155
pubmed: 30523332
Prostate Cancer Prostatic Dis. 2021 Sep;24(3):623-637
pubmed: 33568748
BMC Cancer. 2014 May 21;14:352
pubmed: 24886074
Science. 2016 Mar 11;351(6278):1214-8
pubmed: 26912360
Nutrients. 2021 Dec 16;13(12):
pubmed: 34960055
Cancer Cell. 2015 Jan 12;27(1):57-71
pubmed: 25584894
Nature. 2012 Aug 16;488(7411):337-42
pubmed: 22895339
J Mol Biol. 1961 Jun;3:318-56
pubmed: 13718526
Med Oncol. 2015 Jan;32(1):391
pubmed: 25433947
Cancer Res. 2004 Mar 15;64(6):2070-5
pubmed: 15026345
Front Endocrinol (Lausanne). 2019 May 07;10:294
pubmed: 31133988
Cell Death Discov. 2022 Mar 30;8(1):143
pubmed: 35354789
Cell. 2010 Jan 8;140(1):49-61
pubmed: 20079333
Cell Metab. 2016 Nov 8;24(5):657-671
pubmed: 27641098
Nat Rev Nephrol. 2020 Mar;16(3):156-172
pubmed: 31636445
Cell Rep. 2020 Jul 7;32(1):107848
pubmed: 32640218
Nat Rev Cancer. 2016 Nov;16(11):708-717
pubmed: 27562461
Nature. 2022 Mar;603(7899):159-165
pubmed: 35197629
Science. 2000 Jun 30;288(5475):2379-81
pubmed: 10875926
Nat Rev Genet. 2020 Dec;21(12):737-753
pubmed: 32908249
Nat Metab. 2021 Jan;3(1):21-32
pubmed: 33398194
Oncol Rep. 2010 May;23(5):1233-9
pubmed: 20372835
Oncol Rep. 2019 Jul;42(1):224-230
pubmed: 31180564
Nat Genet. 2021 Dec;53(12):1664-1672
pubmed: 34857952
J Clin Oncol. 2012 Dec 20;30(36):e386-9
pubmed: 23169519
Mol Cell. 2014 Nov 6;56(3):414-424
pubmed: 25458842
Cancer Res. 2021 Jun 1;81(11):2824-2832
pubmed: 33762358
Int J Mol Sci. 2020 Nov 07;21(21):
pubmed: 33171818
J Clin Invest. 2022 Jan 4;132(1):
pubmed: 34981784
Mol Cell. 2018 Aug 2;71(3):398-408
pubmed: 30075141
Trends Endocrinol Metab. 2021 Apr;32(4):198-211
pubmed: 33518451
Nat Med. 2018 Feb;24(2):194-202
pubmed: 29334372
Nat Rev Cancer. 2018 Nov;18(11):681-695
pubmed: 30181570
Science. 2009 May 22;324(5930):1029-33
pubmed: 19460998
Mol Cancer Ther. 2022 Oct 7;21(10):1561-1572
pubmed: 35930753
Oncol Rep. 2021 Nov;46(5):
pubmed: 34590156
Clin Cancer Res. 2014 Jun 1;20(11):2846-50
pubmed: 24727321
Cancer Metab. 2013 Sep 06;1(1):19
pubmed: 24280423
Nature. 2021 Aug;596(7873):583-589
pubmed: 34265844
Oncogene. 1999 Feb 11;18(6):1313-24
pubmed: 10022813
Lancet. 2021 Feb 27;397(10276):797-804
pubmed: 33581798
J Clin Invest. 2013 Sep;123(9):3652-8
pubmed: 23999438
Nat Commun. 2022 May 13;13(1):2671
pubmed: 35562357
Dev Cell. 2020 Jul 20;54(2):183-195
pubmed: 32640203
Nat Metab. 2019 Jan;1(1):70-85
pubmed: 31198906
Transl Androl Urol. 2013 Sep;2(3):178-186
pubmed: 25356377
Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):580-585
pubmed: 28049847
J Nucl Med. 2014 Jul;55(7):1144-9
pubmed: 24777291
Nat Med. 2004 Jan;10(1):33-9
pubmed: 14702632
Clin Cancer Res. 2016 Sep 1;22(17):4466-77
pubmed: 27140928
Cell Rep. 2022 Jun 21;39(12):110986
pubmed: 35732125
Prog Lipid Res. 2003 Jul;42(4):289-317
pubmed: 12689621
Front Immunol. 2019 Aug 07;10:1878
pubmed: 31440253
Nat Metab. 2020 Dec;2(12):1413-1426
pubmed: 33230295
J Cell Biol. 2020 Jan 6;219(1):
pubmed: 31690618
Cancer Cell. 2013 Aug 12;24(2):213-228
pubmed: 23911236
Science. 2016 Mar 11;351(6278):1208-13
pubmed: 26912361
Eur Urol Oncol. 2019 Feb;2(1):28-36
pubmed: 30929843
Mol Metab. 2022 Aug;62:101516
pubmed: 35598879
Biosci Rep. 2019 Jun 25;39(6):
pubmed: 31196962
Mol Cancer. 2006 May 15;5:17
pubmed: 16700911
Cell. 2015 Sep 10;162(6):1217-28
pubmed: 26321681
Proc Natl Acad Sci U S A. 2021 Mar 30;118(13):
pubmed: 33753479
Cancer. 1998 Aug 1;83(3):528-37
pubmed: 9690546
Int J Cancer. 2018 Jul 15;143(2):396-407
pubmed: 29441565
J Med Chem. 1996 Dec 20;39(26):5053-63
pubmed: 8978836
Oncogene. 2020 Apr;39(16):3292-3304
pubmed: 32071396
J Immunother Cancer. 2021 Jun;9(6):
pubmed: 34168004
Cancer Lett. 2021 Apr 1;502:180-188
pubmed: 33450358
J Steroid Biochem. 1987 Sep;28(3):247-56
pubmed: 3657147
J Med Chem. 2020 Nov 12;63(21):12957-12977
pubmed: 33118821
Future Med Chem. 2019 Sep;11(17):2333-2352
pubmed: 31581916
Mol Cell. 2022 May 5;82(9):1660-1677.e10
pubmed: 35320754
Br J Cancer. 2020 Jan;122(1):4-22
pubmed: 31819192
Curr Opin Pharmacol. 2018 Aug;41:1-11
pubmed: 29609138
BMC Biol. 2019 Jul 4;17(1):52
pubmed: 31272438
Front Genet. 2021 Nov 03;12:768996
pubmed: 34804127
Clin Cancer Res. 2018 May 1;24(9):2060-2073
pubmed: 29437791
Cancer Lett. 2021 May 1;505:24-36
pubmed: 33617947
Biochem Biophys Res Commun. 2022 Jul 30;615:31-35
pubmed: 35605402
BMC Cancer. 2021 Jul 2;21(1):765
pubmed: 34215227
Cancer Res. 2012 Oct 1;72(19):5130-40
pubmed: 22850421
Hum Cell. 2022 Jan;35(1):1-14
pubmed: 34606041
Sci Signal. 2012 Nov 06;5(249):ra80
pubmed: 23131847
Oncotarget. 2016 Aug 16;7(33):53837-53852
pubmed: 27462778
Nat Commun. 2021 Mar 5;12(1):1455
pubmed: 33674593
J Exp Med. 2019 Dec 2;216(12):2883-2899
pubmed: 31548301
Cancer Discov. 2011 Nov;1(6):487-95
pubmed: 22389870
PLoS One. 2012;7(4):e33738
pubmed: 22485149
Trends Immunol. 2015 Feb;36(2):81-91
pubmed: 25592731
Cancer Res. 2013 Jan 15;73(2):478-82
pubmed: 23135910
Exp Cell Res. 2020 Mar 15;388(2):111846
pubmed: 31945319
Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):8983-8
pubmed: 22615405
Cancer Discov. 2021 May;11(5):1067-1081
pubmed: 33504580
Onco Targets Ther. 2021 May 24;14:3353-3366
pubmed: 34079281
Cancer Res. 2018 Apr 1;78(7):1685-1699
pubmed: 29363545
Mol Cancer Ther. 2021 Mar;20(3):500-511
pubmed: 33361272
Cell. 2019 Jun 27;178(1):176-189.e15
pubmed: 31155231
Invest New Drugs. 2020 Oct;38(5):1495-1506
pubmed: 32198649
J Cell Mol Med. 2022 Sep;26(18):4825-4836
pubmed: 35962606
Cell Rep Med. 2020 May 19;1(2):100014
pubmed: 32478334
Trends Biochem Sci. 2010 Aug;35(8):427-33
pubmed: 20570523
Nature. 2019 Mar;567(7748):341-346
pubmed: 30842654
Int J Mol Sci. 2019 Dec 25;21(1):
pubmed: 31881671
Oncogene. 2020 Apr;39(17):3555-3570
pubmed: 32123312
Nat Rev Cancer. 2013 Aug;13(8):572-83
pubmed: 23822983
Nat Rev Mol Cell Biol. 2012 Apr 04;13(5):297-311
pubmed: 22473470
Nature. 2012 Jul 12;487(7406):239-43
pubmed: 22722839
EBioMedicine. 2021 Nov;73:103627
pubmed: 34656878
Cell Rep. 2014 Sep 11;8(5):1461-74
pubmed: 25176644
Nat Struct Mol Biol. 2019 Jun;26(6):510-517
pubmed: 31160781
Nat Chem Biol. 2013 Apr;9(4):232-40
pubmed: 23508189
Mol Cancer. 2019 May 29;18(1):103
pubmed: 31142332
Nat Commun. 2022 Jan 24;13(1):466
pubmed: 35075123
Nat Rev Drug Discov. 2012 Nov;11(11):873-86
pubmed: 23060265
N Engl J Med. 2018 Apr 12;378(15):1408-1418
pubmed: 29420164
J Chem Inf Model. 2017 May 22;57(5):1018-1028
pubmed: 28441481
Theranostics. 2019 Apr 12;9(8):2183-2197
pubmed: 31149037
Molecules. 2021 Dec 29;27(1):
pubmed: 35011413
Cancer Res. 2022 Jul 5;82(13):2403-2416
pubmed: 35584006
Nat Rev Urol. 2020 Apr;17(4):214-231
pubmed: 32112053
Cancer. 2012 May 1;118(9):2338-66
pubmed: 22460733
Int J Cancer. 2018 Jun 15;142(12):2414-2424
pubmed: 29159872
Cancer Res. 2012 Jun 1;72(11):2746-56
pubmed: 22593198
Semin Cancer Biol. 2022 Jul;82:94-119
pubmed: 33290846
Br J Haematol. 2006 Jul;134(1):20-6
pubmed: 16803563
Semin Cell Dev Biol. 2020 Feb;98:202-210
pubmed: 31103464
Nature. 2017 Apr 19;544(7650):372-376
pubmed: 28425994
J Biol Chem. 2022 Jun;298(6):102000
pubmed: 35500650
Nat Methods. 2021 Dec;18(12):1452-1456
pubmed: 34862499
Cancer Res. 2021 Aug 1;81(15):4066-4078
pubmed: 34183356
Cancer Sci. 2010 Jan;101(1):173-9
pubmed: 19900191
Int J Mol Sci. 2021 Sep 02;22(17):
pubmed: 34502458
Cell Rep. 2021 Jun 15;35(11):109264
pubmed: 34133930
J Androl. 1998 Mar-Apr;19(2):127-35
pubmed: 9570735
Front Oncol. 2018 Oct 04;8:423
pubmed: 30338242
Prostate Cancer Prostatic Dis. 2022 Jan 25;:
pubmed: 35079115
Oncotarget. 2017 Jun 27;8(26):43356-43367
pubmed: 28498810
Nature. 2011 Nov 20;481(7381):385-8
pubmed: 22101431
Future Oncol. 2017 Apr;13(9):809-819
pubmed: 28125906
Sci Rep. 2017 Nov 23;7(1):16159
pubmed: 29170516
Cell Metab. 2017 Dec 5;26(6):817-829.e6
pubmed: 28988820
Endocr Res. 2000 Feb;26(1):23-39
pubmed: 10711720
J Biol Chem. 1996 Sep 13;271(37):22315-20
pubmed: 8798390
Prostate Cancer Prostatic Dis. 2020 Sep;23(3):441-448
pubmed: 31932660
Biochem J. 2015 Mar 15;466(3):443-54
pubmed: 25748677
J Chem Theory Comput. 2021 Feb 9;17(2):1060-1073
pubmed: 33403848
Chem Biol. 2009 Aug 28;16(8):882-92
pubmed: 19716478
Nat Rev Cancer. 2016 Oct;16(10):650-62
pubmed: 27634448
Cancer Lett. 2021 Apr 10;503:240-248
pubmed: 33246091
Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3450-4
pubmed: 10716717
Cell Oncol (Dordr). 2021 Apr;44(2):385-403
pubmed: 33464483
Nature. 2019 Nov;575(7782):380-384
pubmed: 31666695
Future Med Chem. 2017 Jan;9(2):223-243
pubmed: 28111979
Mol Cell Proteomics. 2015 Sep;14(9):2308-15
pubmed: 25717114
Science. 2019 Nov 22;366(6468):1013-1021
pubmed: 31699883
Nature. 2014 Jun 12;510(7504):278-82
pubmed: 24759320
Nat Rev Endocrinol. 2017 Dec;13(12):710-730
pubmed: 28849786
Mol Syst Biol. 2020 Apr;16(4):e9247
pubmed: 32323921
J Urol. 2016 May;195(5):1588-1597
pubmed: 26682754
Elife. 2019 Feb 05;8:
pubmed: 30717828
BMC Biochem. 2006 Mar 27;7:10
pubmed: 16566829
Ann Transl Med. 2014 Sep;2(9):91
pubmed: 25405166
EBioMedicine. 2017 Feb;16:51-62
pubmed: 28159572
J Cell Physiol. 2021 Jun;236(6):4528-4537
pubmed: 33230810
Expert Opin Ther Targets. 2018 Mar;22(3):201-216
pubmed: 29417861
Adv Sci (Weinh). 2022 Oct;9(28):e2201859
pubmed: 35971165
Int J Biol Sci. 2022 May 13;18(8):3470-3483
pubmed: 35637958
Drug Discov Today. 2013 Nov;18(21-22):1067-73
pubmed: 23850704
Oncotarget. 2015 Sep 15;6(27):24061-74
pubmed: 26183399
Cancer Discov. 2017 May;7(5):478-493
pubmed: 28193778
Cancer Lett. 2018 Oct 10;434:42-55
pubmed: 30009856
ACS Chem Biol. 2013 Dec 20;8(12):2607-21
pubmed: 24228614
J Cancer Res Clin Oncol. 2016 Jan;142(1):5-16
pubmed: 26048031
Clin Cancer Res. 2022 Apr 1;28(7):1446-1459
pubmed: 35078861
Oncotarget. 2015 Oct 13;6(31):31997-2012
pubmed: 26378018
Front Oncol. 2022 May 25;12:873516
pubmed: 35692804
Pharm Res. 2016 Nov;33(11):2594-603
pubmed: 27599991
Mol Metab. 2020 Aug;38:100950
pubmed: 32199820
Clin Cancer Res. 2018 Feb 1;24(3):696-707
pubmed: 29138344
Nat Methods. 2022 Jul;19(7):793-794
pubmed: 35761068
Trends Cancer. 2021 Aug;7(8):714-730
pubmed: 33865798
Nat Commun. 2016 May 19;7:11612
pubmed: 27194471
Asian J Androl. 2016 Sep-Oct;18(5):687-94
pubmed: 27212126
Cold Spring Harb Perspect Med. 2013 Aug 01;3(8):
pubmed: 23906881
Nat Commun. 2020 Jan 7;11(1):52
pubmed: 31911608
Nat Cancer. 2020 Nov;1(11):1041-1053
pubmed: 34258585
J Pathol. 2015 Jul;236(3):278-89
pubmed: 25693838
Cell Metab. 2019 Sep 3;30(3):434-446
pubmed: 31484055
Nat Methods. 2022 Jul;19(7):854-864
pubmed: 35761067
Nat Rev Cancer. 2011 May;11(5):325-37
pubmed: 21508971
JAMA Oncol. 2018 Feb 01;4(2):217-224
pubmed: 29121144
Nat Chem Biol. 2014 Sep;10(9):774-9
pubmed: 25086508
Prostate Cancer Prostatic Dis. 2020 Dec;23(4):718-723
pubmed: 32661432
Invest New Drugs. 2022 Oct;40(5):1001-1010
pubmed: 35802288
N Engl J Med. 1948 Jun 3;238(23):787-93
pubmed: 18860765
Cancer Metab. 2018 Aug 17;6:10
pubmed: 30140438
Mol Inform. 2020 Aug;39(8):e2000028
pubmed: 32162456
Cell Metab. 2006 Sep;4(3):211-21
pubmed: 16950138
Trends Pharmacol Sci. 2018 Mar;39(3):307-325
pubmed: 29254698
Oncotarget. 2018 Jun 12;9(45):27698-27707
pubmed: 29963230
Prostate Cancer Prostatic Dis. 2019 Mar;22(1):49-58
pubmed: 30104655
EClinicalMedicine. 2021 Mar 30;34:100797
pubmed: 33870151
Cancer Lett. 2020 Aug 10;485:45-55
pubmed: 32428663
Drug Discov Today. 2022 Sep;27(9):2574-2585
pubmed: 35609742
J Lipid Res. 1995 Jul;36(7):1507-21
pubmed: 7595075
Prostaglandins Other Lipid Mediat. 2006 Sep;80(3-4):165-74
pubmed: 16939881
Cell. 2000 Jan 7;100(1):57-70
pubmed: 10647931
Signal Transduct Target Ther. 2022 Jun 24;7(1):198
pubmed: 35750683
Cell. 2015 Nov 5;163(4):1011-25
pubmed: 26544944
Cancers (Basel). 2021 Apr 29;13(9):
pubmed: 33947068
Cancer Cell. 2022 Feb 14;40(2):201-218.e9
pubmed: 35090594
Proc Natl Acad Sci U S A. 2018 May 15;115(20):E4584-E4593
pubmed: 29712835
Front Biosci (Landmark Ed). 2019 Jan 1;24(2):366-381
pubmed: 30468661
J Mol Med (Berl). 2011 Nov;89(11):1137-48
pubmed: 21769686
Mol Cancer Res. 2021 Aug;19(8):1398-1411
pubmed: 34088870
Adv Radiat Oncol. 2020 Jun 29;5(5):994-1005
pubmed: 33083663
Cancer Metab. 2013 Feb 04;1(1):8
pubmed: 24280138
ACS Med Chem Lett. 2018 Jan 19;9(4):300-305
pubmed: 29670690
Cancer Cell. 2019 Mar 18;35(3):385-400.e9
pubmed: 30827887
Nat Rev Drug Discov. 2022 Jul;21(7):477-479
pubmed: 35710832
Mol Cell. 2014 Nov 6;56(3):400-413
pubmed: 25458841
Oncogene. 2017 Jan 26;36(4):525-533
pubmed: 27375016
Int J Clin Exp Med. 2015 Jul 15;8(7):10577-85
pubmed: 26379847
Nat Commun. 2020 May 15;11(1):2429
pubmed: 32415067
Cancer Res. 2013 Mar 15;73(6):1900-11
pubmed: 23302227
Biochim Biophys Acta. 2009 Jun;1791(6):494-500
pubmed: 19010445
Ann Oncol. 2011 Nov;22(11):2476-2481
pubmed: 21436186
Trends Cell Biol. 2017 Nov;27(11):863-875
pubmed: 28734735
Cancer Res. 2008 Jul 1;68(13):5469-77
pubmed: 18593950
Int J Cancer. 2002 Mar 1;98(1):19-22
pubmed: 11857379
Bioorg Med Chem Lett. 2011 Oct 1;21(19):5924-7
pubmed: 21873051
Nat Rev Cancer. 2016 Oct;16(10):619-34
pubmed: 27492215
Science. 1956 Aug 10;124(3215):269-70
pubmed: 13351639
Elife. 2016 Feb 27;5:e10250
pubmed: 26920219
Mol Cell. 2014 Nov 6;56(3):425-435
pubmed: 25458843
Development. 2022 Jul 15;149(14):
pubmed: 35735108
Cell Metab. 2018 Feb 6;27(2):428-438.e5
pubmed: 29337136
Oncotarget. 2017 May 11;8(39):65143-65151
pubmed: 29029419
Diabetologia. 2007 Jul;50(7):1472-80
pubmed: 17492427
Cell. 2021 Jan 21;184(2):370-383.e13
pubmed: 33333023
N Engl J Med. 2012 Sep 27;367(13):1187-97
pubmed: 22894553
EJNMMI Res. 2013 Apr 24;3(1):31
pubmed: 23618081
Int J Mol Sci. 2022 May 09;23(9):
pubmed: 35563663
iScience. 2022 Jun 17;25(7):104630
pubmed: 35800753
Cancer Discov. 2022 Jan;12(1):31-46
pubmed: 35022204
Cell Rep. 2014 May 22;7(4):1248-58
pubmed: 24813884
Cancer Res. 2017 Dec 15;77(24):6795-6811
pubmed: 29247038
Cell Mol Bioeng. 2020 Sep 21;13(5):541-557
pubmed: 33184582
Mol Cell Biol. 2006 Jul;26(13):4863-71
pubmed: 16782875
Cold Spring Harb Perspect Med. 2019 Jan 2;9(1):
pubmed: 29530944
Cancer Med. 2018 Jul;7(7):3385-3392
pubmed: 29905005
Biochim Biophys Acta. 2013 Oct;1831(10):1518-32
pubmed: 23562839
Prostate Cancer Prostatic Dis. 2015 Dec;18(4):325-32
pubmed: 26260996
Front Cell Dev Biol. 2021 Jan 12;8:603837
pubmed: 33511116
Cancer Res. 2018 Aug 15;78(16):4459-4470
pubmed: 29891507
Cancer Res. 2014 Feb 1;74(3):908-20
pubmed: 24285728
Cancer Res. 2004 Mar 15;64(6):2212-21
pubmed: 15026365
Nature. 2019 Oct;574(7779):575-580
pubmed: 31645732
Biol Chem Hoppe Seyler. 1986 Sep;367(9):905-12
pubmed: 3790257
Appl Biochem Biotechnol. 2016 Mar;178(5):900-23
pubmed: 26547852
J Nucl Med. 2020 Jun;61(6):904-910
pubmed: 31806771
NPJ Precis Oncol. 2022 May 4;6(1):31
pubmed: 35508696
Mol Metab. 2021 Jul;49:101195
pubmed: 33609766
Biochemistry. 2018 Jun 26;57(25):3433-3444
pubmed: 29648801
Nat Med. 2018 Jul;24(7):1036-1046
pubmed: 29892070
Biochem Soc Trans. 2021 Dec 17;49(6):2561-2572
pubmed: 34854890
Int J Mol Sci. 2020 Sep 25;21(19):
pubmed: 32993041
N Engl J Med. 2015 Oct 29;373(18):1697-708
pubmed: 26510020
Arch Biochem Biophys. 2016 Dec 1;611:100-112
pubmed: 27132038
Eur J Cancer. 2022 Jul;170:285-295
pubmed: 35643841
Prog Nucleic Acid Res Mol Biol. 2001;70:33-75
pubmed: 11642366
Am J Pathol. 1997 Jan;150(1):201-8
pubmed: 9006336
Diagnostics (Basel). 2022 Mar 10;12(3):
pubmed: 35328229
PLoS One. 2016 Nov 15;11(11):e0163694
pubmed: 27846210
J Clin Invest. 2016 Feb;126(2):706-20
pubmed: 26731476
Oncogene. 2020 Oct;39(44):6747-6756
pubmed: 32978521
Cell Chem Biol. 2016 Jan 21;23(1):3-9
pubmed: 26933731
Oncotarget. 2017 Apr 18;8(16):25928-25941
pubmed: 28460430
Cell Immunol. 2014 May-Jun;289(1-2):42-8
pubmed: 24721110
Endocr Relat Cancer. 2017 Sep;24(9):R335-R348
pubmed: 28808043
Dis Model Mech. 2011 Nov;4(6):727-32
pubmed: 22065843
Cell Rep. 2016 Sep 13;16(11):3016-3027
pubmed: 27626669
Circ Res. 2019 Dec 6;125(12):1087-1102
pubmed: 31625810
Mol Metab. 2022 May;59:101466
pubmed: 35219875
Int J Mol Sci. 2021 May 25;22(11):
pubmed: 34070384
Biochim Biophys Acta Mol Basis Dis. 2021 Jul 1;1867(7):166151
pubmed: 33892077
Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):631-640
pubmed: 30578319
Cancer Sci. 2021 May;112(5):1899-1910
pubmed: 33619826
Int J Mol Sci. 2020 Nov 12;21(22):
pubmed: 33198356
Cancer Cell. 2017 Oct 9;32(4):474-489.e6
pubmed: 29017058
J Biol Chem. 1993 Aug 25;268(24):17665-8
pubmed: 7688729
Nat Med. 2016 Oct;22(10):1108-1119
pubmed: 27643638
Int J Radiat Biol. 2019 Jul;95(7):912-919
pubmed: 30822194
J Am Chem Soc. 2015 Feb 25;137(7):2695-703
pubmed: 25625324
J Cell Physiol. 2022 Jan;237(1):128-148
pubmed: 34311499
EMBO Rep. 2016 Dec;17(12):1721-1730
pubmed: 27856534
Trends Biochem Sci. 2014 Apr;39(4):191-8
pubmed: 24657017
J Clin Invest. 2019 Jul 2;129(8):3006-3017
pubmed: 31264969
Nat Commun. 2021 Apr 23;12(1):2398
pubmed: 33893278
Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9498-502
pubmed: 12060712
Nat Commun. 2021 Mar 22;12(1):1812
pubmed: 33753739
J Clin Invest. 2013 Jul;123(7):2948-60
pubmed: 23722902
Oncogene. 2016 May 12;35(19):2441-52
pubmed: 26279298
Am J Surg Pathol. 2001 Nov;25(11):1397-404
pubmed: 11684956
Semin Nucl Med. 2016 Nov;46(6):502-506
pubmed: 27825430
Annu Rev Pharmacol Toxicol. 2022 Jan 6;62:131-153
pubmed: 34449248
Expert Opin Investig Drugs. 2020 Feb;29(2):135-141
pubmed: 31519114
Sci Adv. 2016 May 27;2(5):e1600200
pubmed: 27386546
Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):E1796-805
pubmed: 26976583
Nat Rev Urol. 2019 Nov;16(11):645-654
pubmed: 31591549
Int J Clin Exp Pathol. 2017 Nov 01;10(11):11080-11089
pubmed: 31966456
Cancers (Basel). 2021 Feb 01;13(3):
pubmed: 33535541
Science. 2009 May 8;324(5928):787-90
pubmed: 19359544
Cell. 2018 Feb 22;172(5):1022-1037.e14
pubmed: 29429633