Impact of Oxidative Stress on Molecular Mechanisms of Cervical Ripening in Pregnant Women.
RNS
ROS
cervical ripening
cervix
gestation
oxidative stress
pregnancy
reactive nitrogen species
reactive oxygen species
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
24 Oct 2022
24 Oct 2022
Historique:
received:
26
09
2022
revised:
13
10
2022
accepted:
21
10
2022
entrez:
11
11
2022
pubmed:
12
11
2022
medline:
15
11
2022
Statut:
epublish
Résumé
Uterine cervix is one of the essential factors in labor and maintaining the proper course of pregnancy. During the last days of gestation, the cervix undergoes extensive changes manifested by transformation from a tight and rigid to one that is soft and able to dilate. These changes can be summarized as "cervical ripening". Changes in the cervical tissue can be referred to as remodeling of the extracellular matrix. The entire process is the result of a close relationship between biochemical and molecular pathways, which is strictly controlled by inflammatory and endocrine factors. When the production of reactive oxygen species exceeds the antioxidant capacity, oxidative stress occurs. A physiologic increase of reactive oxygen species (ROS) and reactive nitrogen species (RNS) is observed through pregnancy. ROS play important roles as second messengers in many intracellular signaling cascades contributing to the course of gestation. This review considers their involvement in the cervical ripening process, emphasizing the molecular and biochemical pathways and the clinical implications.
Identifiants
pubmed: 36361572
pii: ijms232112780
doi: 10.3390/ijms232112780
pmc: PMC9657514
pii:
doi:
Substances chimiques
Reactive Oxygen Species
0
Reactive Nitrogen Species
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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