Increased Arterial Responsiveness to Angiotensin II in Mice Conceived by Assisted Reproductive Technologies.
DNA methylation
angiotensin II receptors
assisted reproductive technologies
hypertension
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
01 Nov 2022
01 Nov 2022
Historique:
received:
22
09
2022
revised:
24
10
2022
accepted:
25
10
2022
entrez:
11
11
2022
pubmed:
12
11
2022
medline:
15
11
2022
Statut:
epublish
Résumé
Since the first report in 1978, the number of individuals conceived by Assisted Reproductive Technologies (ART) has grown incessantly. In parallel, with the recent emergence of possible underlying mechanisms of ART-induced epigenetic changes in the renin-angiotensin system, the cardiovascular repercussions of ART in mice and human offspring (including arterial hypertension, vascular dysfunction, and cardiac remodeling) have become increasingly recognized. Here, we hypothesized that ART may increase arterial responsiveness to angiotensin II (ANG II) by epigenetically modifying the expression of its receptors. To test this hypothesis, we assessed the vasoconstrictor responsiveness to ANG II in isolated aortas from ART and control mice. We also examined ANG II receptor (ATR) type 1 and 2 expression and the promoter methylation of the
Identifiants
pubmed: 36362144
pii: ijms232113357
doi: 10.3390/ijms232113357
pmc: PMC9654033
pii:
doi:
Substances chimiques
Angiotensin II
11128-99-7
Receptor, Angiotensin, Type 1
0
Receptor, Angiotensin, Type 2
0
Vasoconstrictor Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : the Placide Nicod Foundation to Scherrer, and from the Swiss National Science Foundation
ID : 320030_185023/1
Organisme : Swiss Heart Foundation
ID : FF18038
Organisme : Mach-Gaensslen Foundation to Rexhaj
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