Biodereplication of Antiplasmodial Extracts: Application of the Amazonian Medicinal Plant
Piper coruscans Kunth (Piperaceae)
Plasmodium
biodereplication
heme binding
mass spectrometry
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
07 Nov 2022
07 Nov 2022
Historique:
received:
07
10
2022
revised:
01
11
2022
accepted:
05
11
2022
entrez:
11
11
2022
pubmed:
12
11
2022
medline:
15
11
2022
Statut:
epublish
Résumé
Improved methodological tools to hasten antimalarial drug discovery remain of interest, especially when considering natural products as a source of drug candidates. We propose a biodereplication method combining the classical dereplication approach with the early detection of potential antiplasmodial compounds in crude extracts. Heme binding is used as a surrogate of the antiplasmodial activity and is monitored by mass spectrometry in a biomimetic assay. Molecular networking and automated annotation of targeted mass through data mining were followed by mass-guided compound isolation by taking advantage of the versatility and finely tunable selectivity offered by centrifugal partition chromatography. This biodereplication workflow was applied to an ethanolic extract of the Amazonian medicinal plant
Identifiants
pubmed: 36364460
pii: molecules27217638
doi: 10.3390/molecules27217638
pmc: PMC9656727
pii:
doi:
Substances chimiques
Antimalarials
0
Plant Extracts
0
Heme
42VZT0U6YR
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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