Studying the Interactions of U24 from HHV-6 in Order to Further Elucidate Its Potential Role in MS.
Fyn-SH3
Killer Cell Immunoglobulin Like Receptor 2DL2
Nedd4L
Roseolovirus
human herpes virus
multiple sclerosis
natural killer cells
phosphorylation
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
28 10 2022
28 10 2022
Historique:
received:
20
09
2022
revised:
27
10
2022
accepted:
27
10
2022
entrez:
11
11
2022
pubmed:
12
11
2022
medline:
15
11
2022
Statut:
epublish
Résumé
A number of studies have suggested that human herpesvirus 6A (HHV-6A) may play a role in multiple sclerosis (MS). Three possible hypotheses have been investigated: (1) U24 from HHV-6A (U24-6A) mimics myelin basic protein (MBP) through analogous phosphorylation and interaction with Fyn-SH3; (2) U24-6A affects endocytic recycling by binding human neural precursor cell (NPC) expressed developmentally down-regulated protein 4-like WW3* domain (hNedd4L-WW3*); and (3) MS patients who express Killer Cell Immunoglobulin Like Receptor 2DL2 (KIR2DL2) on natural killer (NK) cells are more susceptible to HHV-6 infection. In this contribution, we examined the validity of these propositions by investigating the interactions of U24 from HHV-6B (U24-6B), a variant less commonly linked to MS, with Fyn-SH3 and hNedd4L-WW3* using heteronuclear single quantum coherence (HSQC) nuclear magnetic resonance (NMR) titrations and isothermal titration calorimetry (ITC). In addition, the importance of phosphorylation and the specific role of U24 in NK cell activation in MS patients were examined. Overall, the findings allowed us to shed light into the models linking HHV-6 to MS and the involvement of U24.
Identifiants
pubmed: 36366483
pii: v14112384
doi: 10.3390/v14112384
pmc: PMC9696605
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Front Immunol. 2020 Sep 18;11:2142
pubmed: 33072077
Front Cell Neurosci. 2014 Jan 06;7:284
pubmed: 24431989
Front Immunol. 2019 Nov 26;10:2715
pubmed: 32038605
J Neurochem. 1999 Sep;73(3):1090-7
pubmed: 10461899
Ann Neurol. 2003 Feb;53(2):189-97
pubmed: 12557285
Nat Neurosci. 2016 Feb;19(2):190-7
pubmed: 26814588
Mol Cell Biol. 2000 Nov;20(22):8526-35
pubmed: 11046148
Curr Opin Virol. 2014 Dec;9:127-33
pubmed: 25462444
Protein Sci. 2006 Jan;15(1):162-70
pubmed: 16373478
Biochim Biophys Acta. 2016 Jun;1858(6):1262-77
pubmed: 26903219
Neuron. 2020 Mar 18;105(6):1027-1035.e2
pubmed: 31983538
PLoS Pathog. 2015 Sep 02;11(9):e1005145
pubmed: 26333068
J Infect Dis. 1994 Dec;170(6):1586-9
pubmed: 7996000
Int Immunopharmacol. 2021 Mar;92:107361
pubmed: 33429335
Mol Cell Proteomics. 2005 Aug;4(8):1155-66
pubmed: 15929943
Biochemistry. 2014 Sep 30;53(38):6092-102
pubmed: 25225878
Immunol Lett. 2020 Jun;222:1-11
pubmed: 32113900
PLoS One. 2021 Aug 5;16(8):e0255608
pubmed: 34352002
Sci Rep. 2018 Mar 13;8(1):4447
pubmed: 29535361
Int Immunol. 1998 Nov;10(11):1665-72
pubmed: 9846695
J Am Chem Soc. 2014 Sep 10;136(36):12702-11
pubmed: 25105554
PLoS Pathog. 2013 Jan;9(1):e1003138
pubmed: 23382677
J Comput Chem. 2004 Oct;25(13):1605-12
pubmed: 15264254
J Immunol. 2013 Oct 15;191(8):3973-9
pubmed: 24098055
Science. 2022 Jan 21;375(6578):296-301
pubmed: 35025605
Biochem J. 2015 Nov 15;472(1):17-32
pubmed: 26518750
Science. 1986 Oct 31;234(4776):596-601
pubmed: 2876520
J Biol Chem. 2014 Oct 3;289(40):27911-23
pubmed: 25122758
Neurology. 1996 Apr;46(4):907-11
pubmed: 8780061
Biochemistry. 2008 Jan 8;47(1):267-82
pubmed: 18067320
Lancet. 2008 Oct 25;372(9648):1502-17
pubmed: 18970977
Prog Nucl Magn Reson Spectrosc. 2013 Aug;73:1-16
pubmed: 23962882
Sci Rep. 2017 Jan 04;7:39776
pubmed: 28051106
Dev Cell. 2015 Jul 27;34(2):152-67
pubmed: 26166300
Viruses. 2022 Jan 28;14(2):
pubmed: 35215874
Biochemistry. 2006 Jan 17;45(2):391-401
pubmed: 16401070
Mol Cell Proteomics. 2003 Jul;2(7):453-62
pubmed: 12832457
Cell. 1995 Mar 10;80(5):695-705
pubmed: 7534214
Mult Scler Relat Disord. 2018 Aug;24:157-174
pubmed: 30015080
J Alzheimers Dis. 2019;67(4):1379-1389
pubmed: 30689576
Ann Rheum Dis. 2022 Jan;81(1):34-40
pubmed: 34620584
Exp Cell Res. 2000 Jun 15;257(2):332-40
pubmed: 10837147
Pediatrics. 2014 Jun;133(6):e1541-7
pubmed: 24819578
Ann Neurol. 2001 Jul;50(1):121-7
pubmed: 11456302
Neuron. 2010 Feb 11;65(3):358-72
pubmed: 20159449
J Neuroimmunol. 1996 Mar;65(1):55-9
pubmed: 8642064
Neurology. 1983 Nov;33(11):1444-52
pubmed: 6685237
Viruses. 2020 Jun 13;12(6):
pubmed: 32545816
J Virol. 2017 Apr 13;91(9):
pubmed: 28202752
J Immunol. 2011 Sep 15;187(6):3286-91
pubmed: 21849685
J Neurol Neurosurg Psychiatry. 1993 Aug;56(8):917-9
pubmed: 8394408
J Virol. 2019 Nov 26;93(24):
pubmed: 31578295
Mult Scler. 2018 Jan;24(1):48-52
pubmed: 29307291
J Virol. 2008 Jan;82(2):602-8
pubmed: 17977973
J Virol. 2014 May;88(10):5421-36
pubmed: 24574405
Immunopharmacol Immunotoxicol. 2016 Aug;38(4):303-9
pubmed: 27251940
Mult Scler. 2019 Jan;25(1):81-91
pubmed: 29064315
Neuron. 2006 May 18;50(4):549-59
pubmed: 16701206
Eur J Neurol. 2014 Aug;21(8):1096-1101
pubmed: 24724742
Elife. 2019 Dec 24;8:
pubmed: 31873071
J Virol. 2016 Oct 14;90(21):9608-9617
pubmed: 27535049
BMC Res Notes. 2014 Jun 24;7:387
pubmed: 24956930
Nat Neurosci. 2010 Sep;13(9):1075-81
pubmed: 20694004
Genes Dev. 2020 Sep 1;34(17-18):1177-1189
pubmed: 32792353
Epilepsia Open. 2021 Dec;6(4):777-780
pubmed: 34324277
Microorganisms. 2022 Feb 23;10(3):
pubmed: 35336070
Front Immunol. 2021 Feb 19;12:616853
pubmed: 33679757
Glia. 2006 Jun;53(8):789-98
pubmed: 16541415
Clin Cancer Res. 2005 Apr 15;11(8):2889-93
pubmed: 15837738
Neurochem Res. 2007 Feb;32(2):137-58
pubmed: 16900293
Cell Mol Life Sci. 2011 Jun;68(12):2003-12
pubmed: 21207100
J Virol. 2010 Feb;84(3):1265-75
pubmed: 19923186
Brain. 2010 Dec;133(Pt 12):e157
pubmed: 20739348
Arthritis Rheum. 1997 Sep;40(9):1725
pubmed: 9324032
PLoS One. 2013;8(3):e58122
pubmed: 23526966
BMJ Open. 2017 May 29;7(5):e015546
pubmed: 28554934
Eur J Neurol. 2021 Feb;28(2):579-586
pubmed: 33065762
Biosci Rep. 2014 Dec 08;34(6):e00157
pubmed: 25343306
J Am Chem Soc. 2009 Apr 1;131(12):4355-67
pubmed: 19267471
Front Immunol. 2021 Jul 07;12:665718
pubmed: 34305896
J Neuroimmunol. 2016 May 15;294:1-5
pubmed: 27138091
Clin Microbiol Rev. 2020 Nov 11;34(1):
pubmed: 33177186
J Neuroimmunol. 2014 Jun 15;271(1-2):30-5
pubmed: 24735502
J Neurochem. 2011 May;117(3):479-93
pubmed: 21332718
J Gen Virol. 2005 Apr;86(Pt 4):1035-1044
pubmed: 15784897
FEBS Lett. 2008 Aug 6;582(18):2685-8
pubmed: 18616943
J Virol. 1997 Jun;71(6):4752-60
pubmed: 9151869
J Neurovirol. 2013 Feb;19(1):42-7
pubmed: 23179681
J Clin Virol. 2009 Sep;46(1):47-8
pubmed: 19505843
Eur J Neurol. 2021 Sep;28(9):3072-3079
pubmed: 34107122
Biochem Cell Biol. 2017 Jun;95(3):350-358
pubmed: 28314105
J Infect Dis. 2000 Nov;182(5):1321-5
pubmed: 11023456
Biochemistry. 1996 Dec 10;35(49):15646-53
pubmed: 8961927
J Infect Dis. 2015 Oct 1;212(7):1011-3
pubmed: 25840442
New Microbiol. 2007 Jul;30(3):173-87
pubmed: 17802896
J Neurosci Res. 2012 Jan;90(1):28-47
pubmed: 21887699
Mult Scler. 2022 Mar;28(3):383-392
pubmed: 34124961
J Biomol NMR. 1998 Aug;12(2):259-76
pubmed: 9751998
J Neuroimmunol. 2012 Oct 15;251(1-2):55-64
pubmed: 22871633
Cells. 2020 Dec 04;9(12):
pubmed: 33291793
Structure. 1996 Jun 15;4(6):705-14
pubmed: 8805554
Am J Reprod Immunol. 2019 Oct;82(4):e13174
pubmed: 31338899