Monocyte-to-HDL ratio and non-HDL cholesterol were predictors of septic shock in newborns.
Late-onset neonatal sepsis
Lipoproteins
Monocyte-to-HDL ratio
Septic shock
Journal
Clinics (Sao Paulo, Brazil)
ISSN: 1980-5322
Titre abrégé: Clinics (Sao Paulo)
Pays: United States
ID NLM: 101244734
Informations de publication
Date de publication:
2022
2022
Historique:
received:
11
05
2022
revised:
11
08
2022
accepted:
29
08
2022
pubmed:
12
11
2022
medline:
19
11
2022
entrez:
11
11
2022
Statut:
epublish
Résumé
The association between lipoprotein levels and late-onset neonatal sepsis has shown controversial results. The aims are to assess lipid profile, cytokines, and Monocyte-to-HDL (M/H) ratio as diagnostic and prognostic markers for late-onset neonatal sepsis. This prospective study included 49 septic neonates and 17 controls. Cholesterol (CT), Triglyceride (TG), Very-Low-Density (VLDLc), Low-Density (LDLc), and High-Density Lipoproteins (HDLc) were measured at admission (D0) and on days 3, 7 and 10 to evaluate septic shock outcomes. Cytokines and monocytes were evaluated by flow cytometry. Septic newborns showed higher IL-6 and IL-8 at D0 and CT levels on D7 and on D10, which also presented higher TG, VLDLc and non-HDL cholesterol concentrations than controls. The septic shock group (n = 22) revealed a higher number of male subjects, CRP, IL-6, IL-8 and IL-10 levels, while lower TG, HDLc, monocyte numbers and M/H ratio at admission compared to the non-shock group (n = 27). M/H ratio and non-HDL cholesterol on D0 were risk factors for septic shock (OR = 0.70, 0.49‒0.99; OR = 0.96, 0.92‒0.99, respectively). Decreasing levels from D0 to D3 of CT (OR = 0.96, 0.93‒0.99), VLDLc (OR = 0.91, 0.85‒0.98), and non-HDL cholesterol (OR = 0.92, 0.87‒0.98) were also predictors of septic shock. Lower M/H ratios and non-HDL cholesterol at admission and decreasing levels of cholesterol, VLDLc and non-HDL cholesterol during a hospital stay are associated with the development of septic shock in newborns with late-onset neonatal sepsis.
Sections du résumé
BACKGROUND
The association between lipoprotein levels and late-onset neonatal sepsis has shown controversial results. The aims are to assess lipid profile, cytokines, and Monocyte-to-HDL (M/H) ratio as diagnostic and prognostic markers for late-onset neonatal sepsis.
METHODS
This prospective study included 49 septic neonates and 17 controls. Cholesterol (CT), Triglyceride (TG), Very-Low-Density (VLDLc), Low-Density (LDLc), and High-Density Lipoproteins (HDLc) were measured at admission (D0) and on days 3, 7 and 10 to evaluate septic shock outcomes. Cytokines and monocytes were evaluated by flow cytometry.
RESULTS
Septic newborns showed higher IL-6 and IL-8 at D0 and CT levels on D7 and on D10, which also presented higher TG, VLDLc and non-HDL cholesterol concentrations than controls. The septic shock group (n = 22) revealed a higher number of male subjects, CRP, IL-6, IL-8 and IL-10 levels, while lower TG, HDLc, monocyte numbers and M/H ratio at admission compared to the non-shock group (n = 27). M/H ratio and non-HDL cholesterol on D0 were risk factors for septic shock (OR = 0.70, 0.49‒0.99; OR = 0.96, 0.92‒0.99, respectively). Decreasing levels from D0 to D3 of CT (OR = 0.96, 0.93‒0.99), VLDLc (OR = 0.91, 0.85‒0.98), and non-HDL cholesterol (OR = 0.92, 0.87‒0.98) were also predictors of septic shock.
CONCLUSIONS
Lower M/H ratios and non-HDL cholesterol at admission and decreasing levels of cholesterol, VLDLc and non-HDL cholesterol during a hospital stay are associated with the development of septic shock in newborns with late-onset neonatal sepsis.
Identifiants
pubmed: 36368184
pii: S1807-5932(22)03312-9
doi: 10.1016/j.clinsp.2022.100111
pmc: PMC9649365
pii:
doi:
Substances chimiques
Cholesterol
97C5T2UQ7J
Cholesterol, HDL
0
Cytokines
0
Interleukin-6
0
Interleukin-8
0
Lipoproteins
0
Triglycerides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
100111Informations de copyright
Copyright © 2022 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
Arch Dis Child. 2021 Jan 22;:
pubmed: 33483376
Shock. 2004 Mar;21(3):210-21
pubmed: 14770033
Pediatr Rep. 2011 Feb 24;3(1):e1
pubmed: 21647274
JPEN J Parenter Enteral Nutr. 2020 Feb;44 Suppl 1:S45-S54
pubmed: 32049399
Ther Clin Risk Manag. 2014 Feb 27;10:147-50
pubmed: 24600230
Clin Chim Acta. 1994 Aug;228(2):171-9
pubmed: 7988033
Intensive Care Med. 2020 Feb;46(Suppl 1):10-67
pubmed: 32030529
Pediatr Surg Int. 2005 May;21(5):335-40
pubmed: 15834730
Crit Care. 2020 Apr 7;24(1):134
pubmed: 32264946
Rev Chilena Infectol. 2014 Feb;31(1):34-43
pubmed: 24740772
Scand J Infect Dis. 2009;41(4):263-7
pubmed: 19221931
Biol Trace Elem Res. 2021 Apr;199(4):1306-1315
pubmed: 33219922
Nutrients. 2017 Apr 14;9(4):
pubmed: 28420095
Burns Trauma. 2021 Mar 22;9:tkaa040
pubmed: 33768121
Crit Care Med. 2003 May;31(5):1359-66
pubmed: 12771603
J Crit Care. 2017 Apr;38:289-294
pubmed: 28013095
J Infect Dis. 2000 Jun;181 Suppl 3:S462-72
pubmed: 10839741
J Crit Care. 2014 Oct;29(5):723-7
pubmed: 24891152
Clin Appl Thromb Hemost. 2016 Jul;22(5):476-82
pubmed: 26139836
Stroke. 2005 Apr;36(4):715-9
pubmed: 15746459
J Pediatr (Rio J). 2005 Jul-Aug;81(4):287-92
pubmed: 16106312
Intensive Care Med. 2007 Jan;33(1):13-24
pubmed: 17093985
Lancet. 2018 Nov 10;392(10159):1789-1858
pubmed: 30496104
J Nutr. 2010 Jun;140(6):1127-32
pubmed: 20357081
Pediatr Crit Care Med. 2005 Jan;6(1):2-8
pubmed: 15636651
Am J Emerg Med. 2021 Aug;46:212-216
pubmed: 33071082
Handb Exp Pharmacol. 2015;224:483-508
pubmed: 25522999
Eur J Clin Invest. 2010 Apr;40(4):330-8
pubmed: 20486994
Pediatr Surg Int. 2001 May;17(4):254-8
pubmed: 11409157
Intensive Care Med. 2009 Nov;35(11):1877-85
pubmed: 19669126
J Cell Physiol. 2018 Dec;233(12):9237-9246
pubmed: 30076716
Curr Opin Clin Nutr Metab Care. 2002 Mar;5(2):153-8
pubmed: 11844981
Int Urol Nephrol. 2014 Aug;46(8):1619-25
pubmed: 24853998
Biomed Res Int. 2015;2015:789298
pubmed: 26351639
World Rev Nutr Diet. 2015;112:17-30
pubmed: 25471799
Intensive Care Med. 2007 Jan;33(1):25-35
pubmed: 17093984
Pediatr Neonatol. 2019 Apr;60(2):149-155
pubmed: 29895470
J Pediatr Gastroenterol Nutr. 2014 Feb;58(2):177-82
pubmed: 24048161
Crit Care Med. 2005 Aug;33(8):1688-93
pubmed: 16096442
Br J Pharmacol. 2013 Jun;169(3):493-511
pubmed: 23488589