Variable detection of Omicron-BA.1 and -BA.2 by SARS-CoV-2 rapid antigen tests.
BA.1
BA.2
Nucleocapsid protein
Omicron
RAT
SARS-CoV-2
Sensitivity
Specificity
VOC
Journal
Medical microbiology and immunology
ISSN: 1432-1831
Titre abrégé: Med Microbiol Immunol
Pays: Germany
ID NLM: 0314524
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
14
10
2022
accepted:
22
10
2022
pubmed:
13
11
2022
medline:
16
2
2023
entrez:
12
11
2022
Statut:
ppublish
Résumé
During 2022, the COVID-19 pandemic has been dominated by the variant of concern (VoC) Omicron (B.1.1.529) and its rapidly emerging subvariants, including Omicron-BA.1 and -BA.2. Rapid antigen tests (RATs) are part of national testing strategies to identify SARS-CoV-2 infections on site in a community setting or to support layman's diagnostics at home. We and others have recently demonstrated an impaired RAT detection of infections caused by Omicron-BA.1 compared to Delta. Here, we evaluated the performance of five SARS-CoV-2 RATs in a single-centre laboratory study examining a total of 140 SARS-CoV-2 PCR-positive respiratory swab samples, 70 Omicron-BA.1 and 70 Omicron-BA.2, as well as 52 SARS-CoV-2 PCR-negative swabs collected from March 8th until April 10th, 2022. One test did not meet minimal criteria for specificity. In an assessment of the analytical sensitivity in clinical specimen, the 50% limit of detection (LoD50) ranged from 4.2 × 10
Identifiants
pubmed: 36370197
doi: 10.1007/s00430-022-00752-7
pii: 10.1007/s00430-022-00752-7
pmc: PMC9660148
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
13-23Informations de copyright
© 2022. The Author(s).
Références
Clin Microbiol Infect. 2023 Feb;29(2):225-232
pubmed: 36028089
Lancet. 2022 Jul 9;400(10346):93-96
pubmed: 35780802
Lancet Microbe. 2021 Aug;2(8):e351
pubmed: 34223400
Nat Methods. 2023 Apr;20(4):512-522
pubmed: 36823332
J Clin Virol. 2022 Feb;147:105062
pubmed: 34995991
Dent Mater. 2020 May;36(5):e141-e142
pubmed: 32295707
EBioMedicine. 2022 Jan;75:103774
pubmed: 34959134
Lancet. 2022 Apr 2;399(10332):1303-1312
pubmed: 35305296
Viruses. 2022 Jul 06;14(7):
pubmed: 35891461
Microorganisms. 2021 Dec 15;9(12):
pubmed: 34946190
J Clin Virol. 2022 Aug;153:105214
pubmed: 35738151
Med. 2022 Apr 8;3(4):262-268.e4
pubmed: 35313451
Nat Med. 2022 Jun;28(6):1297-1302
pubmed: 35322239
Med Microbiol Immunol. 2021 Dec;210(5-6):263-275
pubmed: 34415422
Signal Transduct Target Ther. 2022 Apr 26;7(1):138
pubmed: 35474215
Med Microbiol Immunol. 2022 Jun;211(2-3):105-117
pubmed: 35187580
N Engl J Med. 2022 Sep 29;387(13):1236-1238
pubmed: 36121928
J Clin Virol. 2021 Feb;135:104713
pubmed: 33352470
Int J Environ Res Public Health. 2022 May 23;19(10):
pubmed: 35627870
Pathogens. 2021 Jan 05;10(1):
pubmed: 33466537
Emerg Microbes Infect. 2022 Dec;11(1):1394-1401
pubmed: 35536564
Med Microbiol Immunol. 2021 Feb;210(1):65-72
pubmed: 33452927
Lancet Microbe. 2022 Feb;3(2):e90
pubmed: 34849494
EBioMedicine. 2022 Aug;82:104158
pubmed: 35834885
Euro Surveill. 2021 Nov;26(44):
pubmed: 34738515
Viruses. 2021 Oct 29;13(11):
pubmed: 34834991
J Clin Med. 2021 Dec 23;11(1):
pubmed: 35011781
Diagnostics (Basel). 2022 May 01;12(5):
pubmed: 35626282
Diagnostics (Basel). 2022 Apr 21;12(5):
pubmed: 35626204
Nat Microbiol. 2022 Aug;7(8):1161-1179
pubmed: 35798890
Lancet Infect Dis. 2022 Oct;22(10):1422-1423
pubmed: 36084664
J Med Virol. 2022 Oct;94(10):5033-5037
pubmed: 35656593
Lancet Infect Dis. 2022 Oct;22(10):1421-1422
pubmed: 36058228
Microbiol Spectr. 2022 Aug 31;10(4):e0085322
pubmed: 35938792
Cochrane Database Syst Rev. 2020 Aug 26;8:CD013705
pubmed: 32845525
Lancet Microbe. 2021 Jul;2(7):e311-e319
pubmed: 33846704
Euro Surveill. 2021 Nov;26(44):
pubmed: 34738516
Nature. 2022 Mar;603(7902):715-720
pubmed: 35104836
Microorganisms. 2021 Sep 16;9(9):
pubmed: 34576862
Nature. 2021 May;593(7858):266-269
pubmed: 33767447
Med Microbiol Immunol. 2022 Feb;211(1):71-77
pubmed: 35061086