Muscle glycogen unavailability and fat oxidation rate during exercise: Insights from McArdle disease.
anaplerotic
fatty acids
glycogen depletion
glycogen store disease
lactate
muscle fatigue
substrate oxidation
tricarboxylic acid cycle
Journal
The Journal of physiology
ISSN: 1469-7793
Titre abrégé: J Physiol
Pays: England
ID NLM: 0266262
Informations de publication
Date de publication:
02 2023
02 2023
Historique:
received:
17
08
2022
accepted:
31
10
2022
pubmed:
13
11
2022
medline:
3
2
2023
entrez:
12
11
2022
Statut:
ppublish
Résumé
Carbohydrate availability affects fat metabolism during exercise; however, the effects of complete muscle glycogen unavailability on maximal fat oxidation (MFO) rate remain unknown. Our purpose was to examine the MFO rate in patients with McArdle disease, comprising an inherited condition caused by complete blockade of muscle glycogen metabolism, compared to healthy controls. Nine patients (three women, aged 36 ± 12 years) and 12 healthy controls (four women, aged 40 ± 13 years) were studied. Several molecular markers of lipid transport/metabolism were also determined in skeletal muscle (gastrocnemius) and white adipose tissue of McArdle (Pygm p.50R*/p.50R*) and wild-type male mice. Peak oxygen uptake (
Identifiants
pubmed: 36370371
doi: 10.1113/JP283743
pmc: PMC10099855
doi:
Substances chimiques
Glycogen
9005-79-2
Lipids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
551-566Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2022 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.
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