Multiple system atrophy with anti-NAE antibody refractory to immunotherapy: A case report.
Anti-NAE antibody
Cerebellar ataxia
Hashimoto's encephalopathy
Multiple system atrophy
Journal
Clinical neurology and neurosurgery
ISSN: 1872-6968
Titre abrégé: Clin Neurol Neurosurg
Pays: Netherlands
ID NLM: 7502039
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
26
01
2022
revised:
23
10
2022
accepted:
28
10
2022
pubmed:
13
11
2022
medline:
1
12
2022
entrez:
12
11
2022
Statut:
ppublish
Résumé
A 51-year-old Japanese man presented with slowly progressing cerebellar ataxia from age 49. Anti-thyroglobulin, anti-thyroid peroxidase, and anti-NAE antibodies were detected. Brain magnetic resonance imaging showed moderate atrophy of the pons, cerebellum, and middle cerebellar peduncle. Dopamine transporter single-photon emission computed tomography showed normal uptake. With the diagnosis of Hashimoto's encephalopathy, repeated steroid pulse therapy and intravenous immunoglobulin therapy were administered; however, they were ineffective for cerebellar ataxia. Afterwards, autonomic failure and parkinsonism became evident. The final diagnosis was MSA of the cerebellar type. Immunotherapies for patients with MSA with anti-NAE antibodies should be carefully considered.
Identifiants
pubmed: 36370600
pii: S0303-8467(22)00385-7
doi: 10.1016/j.clineuro.2022.107504
pii:
doi:
Substances chimiques
Immunologic Factors
0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
107504Informations de copyright
Copyright © 2022 Elsevier B.V. All rights reserved.