Restricted cafeteria feeding and treadmill exercise improved body composition, metabolic profile and exploratory behavior in obese male rats.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
15 11 2022
15 11 2022
Historique:
received:
14
07
2022
accepted:
31
10
2022
entrez:
15
11
2022
pubmed:
16
11
2022
medline:
19
11
2022
Statut:
epublish
Résumé
The aim of this study was to evaluate, in male Long-Evans rats, whether a restricted-cafeteria diet (CAFR), based on a 30% calorie restriction vs continuous ad libitum cafeteria (CAF) fed animals, administered alone or in combination with moderate treadmill exercise (12 m/min, 35 min, 5 days/week for 8 weeks), was able to ameliorate obesity and the associated risk factors induced by CAF feeding for 18 weeks and to examine the changes in circadian locomotor activity, hypothalamic-pituitary-adrenal (HPA) axis functionality, and stress response elicited by this dietary pattern. In addition to the expected increase in body weight and adiposity, and the development of metabolic dysregulations compatible with Metabolic Syndrome, CAF intake resulted in a sedentary profile assessed by the home-cage activity test, reduced baseline HPA axis activity through decreased corticosterone levels, and boosted exploratory behavior. Both CAFR alone and in combination with exercise reduced abdominal adiposity and hypercholesterolemia compared to CAF. Exercise increased baseline locomotor activity in the home-cage in all dietary groups, boosted exploratory behavior in STD and CAF, partially decreased anxiety-like behavior in CAF and CAFR, but did not affect HPA axis-related parameters.
Identifiants
pubmed: 36379981
doi: 10.1038/s41598-022-23464-7
pii: 10.1038/s41598-022-23464-7
pmc: PMC9666649
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
19545Subventions
Organisme : Universitat Autònoma de Barcelona, Barcelona, Spain
ID : PIF-UAB2018
Organisme : Ministerio de Ciencia e Innovación, Gobierno de España, Spain
ID : BES-2017-081939
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España, Spain
ID : PSI2016-77234-R
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España, Spain
ID : PSI2016-77234-R
Informations de copyright
© 2022. The Author(s).
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