Antibodies as drugs-a Keystone Symposia report.

SARS-CoV-2 allergies antibodies antibody design bispecific antibodies therapeutic antibodies

Journal

Annals of the New York Academy of Sciences
ISSN: 1749-6632
Titre abrégé: Ann N Y Acad Sci
Pays: United States
ID NLM: 7506858

Informations de publication

Date de publication:
01 2023
Historique:
pubmed: 17 11 2022
medline: 12 1 2023
entrez: 16 11 2022
Statut: ppublish

Résumé

Therapeutic antibodies have broad indications across diverse disease states, such as oncology, autoimmune diseases, and infectious diseases. New research continues to identify antibodies with therapeutic potential as well as methods to improve upon endogenous antibodies and to design antibodies de novo. On April 27-30, 2022, experts in antibody research across academia and industry met for the Keystone symposium "Antibodies as Drugs" to present the state-of-the-art in antibody therapeutics, repertoires and deep learning, bispecific antibodies, and engineering.

Identifiants

pubmed: 36382536
doi: 10.1111/nyas.14915
pmc: PMC10103175
mid: NIHMS1886487
doi:

Substances chimiques

Antibodies, Bispecific 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

153-166

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI143865
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008320
Pays : United States
Organisme : Wellcome Trust
ID : 208710/Z/17/Z
Pays : United Kingdom
Organisme : Howard Hughes Medical Institute
Pays : United States

Informations de copyright

© 2022 New York Academy of Sciences.

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Auteurs

Jennifer Cable (J)

PhD Science Writer, New York, New York, USA.

Erica Ollmann Saphire (EO)

Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, USA.
Department of Medicine, University of California San Diego, La Jolla, California, USA.

Adrian C Hayday (AC)

Peter Gorer Department of Immunobiology, King's College London, London, UK.
Cancer Research UK Cancer Immunotherapy Accelerator, London, UK.
Immunosurveillance Laboratory, The Francis Crick Institute, London, UK.

Timothy D Wiltshire (TD)

Mayo Clinic, Rochester, Minnesota, USA.

Jarrod J Mousa (JJ)

Department of Infectious Diseases and Center for Vaccines and Immunology, College of Veterinary Medicine, Athens, Georgia, USA.
Department of Biochemistry and Molecular Biology, Franklin College of Arts and Sciences, University of Georgia, Athens, Georgia, USA.
Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

David P Humphreys (DP)

Protein Sciences, UCB Pharma, Berkshire, UK.

Esther C W Breij (ECW)

Translational Research and Precision Medicine, Genmab BV, Utrecht, the Netherlands.

Pierre Bruhns (P)

Institut Pasteur, Université de Paris, Unit of Antibodies in Therapy and Pathology, Paris, France.

Matteo Broketa (M)

Institut Pasteur, Université de Paris, Unit of Antibodies in Therapy and Pathology, Paris, France.

Genta Furuya (G)

Department of Preventive Medicine and Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.

Blake M Hauser (BM)

Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, USA.

Matthieu Mahévas (M)

Service de Médecine Interne, Centre de Référence des Cytopénies Auto-immunes de l'adulte, Centre Hospitalier Universitaire Henri-Mondor, Assistance Publique-Hôpitaux de Paris, Université Paris-Est Créteil, Créteil, France.

Andrea Carfi (A)

Moderna Inc., Cambridge, Massachusetts, USA.
Department of Pathology, Miller School of Medicine, University of Miami, Miami, Florida, USA.

Tineke Cantaert (T)

Immunology Unit, Institut Pasteur du Cambodge, The Pasteur Network, Phnom Penh, Cambodia.

Peter D Kwong (PD)

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Prabhanshu Tripathi (P)

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Jonathan H Davis (JH)

Invenra, Inc, Madison, Wisconsin, USA.

Neil Brewis (N)

F-star Therapeutics Ltd., Cambridge, UK.

Bruce A Keyt (BA)

IGM Biosciences, Inc., Mountainview, California, USA.

Felix L Fennemann (FL)

Lava Therapeutics, Utrecht, the Netherlands.

Vincent Dussupt (V)

Emerging Infectious Diseases Branch, U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.

Arvind Sivasubramanian (A)

Computational Biology, Adimab, Palo Alto, California, USA.

Philip M Kim (PM)

Department of Molecular Genetics, Donnelly Centre for Cellular and Biomolecular Research, Toronto, Ontario, Canada.
Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.

Reda Rawi (R)

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Eve Richardson (E)

Department of Statistics, University of Oxford, Oxford, UK.

Daniel Leventhal (D)

Generate Biomedicines, Somerville, Massachusetts, USA.

Rachael M Wolters (RM)

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Cecile A W Geuijen (CAW)

Merus N.V., Utrecht, the Netherlands.

Matthew A Sleeman (MA)

Regeneron Pharmaceuticals, Tarrytown, New York, USA.

Niccolo Pengo (N)

Mabylon AG, Schlieren, Switzerland.

Francesca Rose Donnellan (FR)

University of Oxford, Oxford, UK.

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Classifications MeSH