Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
18 11 2022
18 11 2022
Historique:
entrez:
16
11
2022
pubmed:
17
11
2022
medline:
19
11
2022
Statut:
ppublish
Résumé
6-Diazo-5-oxo-l-norleucine (DON) is a glutamine antagonist that suppresses cancer cell metabolism but concurrently enhances the metabolic fitness of tumor CD8
Identifiants
pubmed: 36383674
doi: 10.1126/sciadv.abq5925
pmc: PMC9668306
doi:
Substances chimiques
Prodrugs
0
Diazooxonorleucine
03J0H273KZ
Glutamine
0RH81L854J
Enzyme Inhibitors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
eabq5925Subventions
Organisme : NCI NIH HHS
ID : T32 CA060441
Pays : United States
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