Protein kinase Cι mediates immunosuppression in lung adenocarcinoma.

Mice Animals Carcinoma, Non-Small-Cell Lung / pathology Lung Neoplasms / pathology CD8-Positive T-Lymphocytes Adenocarcinoma of Lung / genetics Immunosuppression Therapy B7-H1 Antigen

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
16 11 2022
Historique:
entrez: 16 11 2022
pubmed: 17 11 2022
medline: 19 11 2022
Statut: ppublish

Résumé

Lung adenocarcinoma (LUAD) is the most prevalent form of non-small cell lung cancer (NSCLC) and a leading cause of cancer death. Immune checkpoint inhibitors (ICIs) of programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) signaling induce tumor regressions in a subset of LUAD, but many LUAD tumors exhibit resistance to ICI therapy. Here, we identified

Identifiants

DOI: 10.1126/scitranslmed.abq5931 PMID: 36383684
pubmed: 36383684
doi: 10.1126/scitranslmed.abq5931
doi:

Substances chimiques

B7-H1 Antigen 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabq5931

Auteurs

Ning Yin (N)

Department of Cancer Biology, Mayo Clinic School of Medicine, Jacksonville, FL 32224, USA.
ORCID: 0000-0002-3546-2550

Yi Liu (Y)

Department of Cancer Biology, Mayo Clinic School of Medicine, Jacksonville, FL 32224, USA.
ORCID: 0000-0001-6706-7806

Capella Weems (C)

Department of Cancer Biology, Mayo Clinic School of Medicine, Jacksonville, FL 32224, USA.

Barath Shreeder (B)

Department of Immunology, Mayo Clinic School of Medicine, Jacksonville, FL 32224, USA.
ORCID: 0000-0001-6435-077X

Yanyan Lou (Y)

Division of Hematology and Oncology, Mayo Clinic School of Medicine, Jacksonville, FL 32224, USA.

Keith L Knutson (KL)

Department of Immunology, Mayo Clinic School of Medicine, Jacksonville, FL 32224, USA.
ORCID: 0000-0001-9932-4467

Nicole R Murray (NR)

Department of Cancer Biology, Mayo Clinic School of Medicine, Jacksonville, FL 32224, USA.
ORCID: 0000-0002-6833-8273

Alan P Fields (AP)

Department of Cancer Biology, Mayo Clinic School of Medicine, Jacksonville, FL 32224, USA.
ORCID: 0000-0001-9529-0888

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Protein kinase Cι mediates immunosuppression...
questionsmedicales.fr › Eucaryotes › Animaux › Protein kinase Cι mediates immunosuppression...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Tumeurs des bronches › Carcinome bronchogénique › Carcinome pulmonaire non à petites cellules › Protein kinase Cι mediates immunosuppression...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Protein kinase Cι mediates immunosuppression...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Protein kinase Cι mediates immunosuppression...
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs du thorax › Adénocarcinome pulmonaire › Protein kinase Cι mediates immunosuppression...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Immunosuppression thérapeutique › Protein kinase Cι mediates immunosuppression...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Antigènes B7 › Antigène CD274 › Protein kinase Cι mediates immunosuppression...