Oxidative stress-induced phosphorylation of JIP4 regulates lysosomal positioning in coordination with TRPML1 and ALG2.
JIP4
Parkinson's disease
autophagy
lysosomal positioning
oxidative stress
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
17 11 2022
17 11 2022
Historique:
revised:
18
09
2022
received:
19
04
2022
accepted:
21
09
2022
entrez:
17
11
2022
pubmed:
18
11
2022
medline:
22
11
2022
Statut:
ppublish
Résumé
Retrograde transport of lysosomes is recognised as a critical autophagy regulator. Here, we found that acrolein, an aldehyde that is significantly elevated in Parkinson's disease patient serum, enhances autophagy by promoting lysosomal clustering around the microtubule organising centre via a newly identified JIP4-TRPML1-ALG2 pathway. Phosphorylation of JIP4 at T217 by CaMK2G in response to Ca
Identifiants
pubmed: 36394115
doi: 10.15252/embj.2022111476
pmc: PMC9670204
doi:
Substances chimiques
Acrolein
7864XYD3JJ
Transient Receptor Potential Channels
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e111476Informations de copyright
©2022 The Authors. Published under the terms of the CC BY 4.0 license.
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