Diaporisoindole B Reduces Lipid Accumulation in THP-1 Macrophage Cells via MAPKs and PPARγ-LXRα Pathways and Promotes the Reverse Cholesterol Transport by Upregulating SR-B1 and LDLR in HepG2 Cells.

Humans PPAR gamma / metabolism Foam Cells / metabolism Hep G2 Cells Liver X Receptors / metabolism Macrophages / metabolism Cholesterol / metabolism Receptors, Scavenger / metabolism ATP-Binding Cassette Transporters / genetics

Journal

Journal of natural products
ISSN: 1520-6025
Titre abrégé: J Nat Prod
Pays: United States
ID NLM: 7906882

Informations de publication

Date de publication:
23 12 2022
Historique:
pubmed: 19 11 2022
medline: 27 12 2022
entrez: 18 11 2022
Statut: ppublish

Résumé

Diaporisoindole B (DPB), an isoprenylisoindole alkaloid isolated from the mangrove endophytic fungus

Identifiants

DOI: 10.1021/acs.jnatprod.2c00715 PMID: 36399085
pubmed: 36399085
doi: 10.1021/acs.jnatprod.2c00715
doi:

Substances chimiques

PPAR gamma 0
Liver X Receptors 0
Cholesterol 97C5T2UQ7J
Receptors, Scavenger 0
ATP-Binding Cassette Transporters 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2769-2778

Auteurs

Hongju Liu (H)

School of Pharmacy, Guangdong Medical University, 1 Xincheng Avenue, Dongguan 523808, People's Republic of China.
ORCID: 0000-0003-4665-3157

Huiyi Xie (H)

School of Pharmacy, Guangdong Medical University, 1 Xincheng Avenue, Dongguan 523808, People's Republic of China.
ORCID: 0000-0003-1065-0376

Changqun Li (C)

School of Pharmacy, Guangdong Medical University, 1 Xincheng Avenue, Dongguan 523808, People's Republic of China.

Lingling Wang (L)

School of Pharmacy, Guangdong Medical University, 1 Xincheng Avenue, Dongguan 523808, People's Republic of China.

Qiling Chen (Q)

School of Pharmacy, Guangdong Medical University, 1 Xincheng Avenue, Dongguan 523808, People's Republic of China.

Xin Ouyang (X)

School of Pharmacy, Guangdong Medical University, 1 Xincheng Avenue, Dongguan 523808, People's Republic of China.
ORCID: 0000-0002-2045-3555

Chong Yan (C)

School of Pharmacy, Guangdong Medical University, 1 Xincheng Avenue, Dongguan 523808, People's Republic of China.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Diaporisoindole B Reduces Lipid Accumulation...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteur PPAR gamma › Diaporisoindole B Reduces Lipid Accumulation...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Cellules spumeuses › Diaporisoindole B Reduces Lipid Accumulation...
questionsmedicales.fr › Cellules › Cellules épithéliales › Hépatocytes › Cellules HepG2 › Diaporisoindole B Reduces Lipid Accumulation...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteurs hépatiques X › Diaporisoindole B Reduces Lipid Accumulation...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Diaporisoindole B Reduces Lipid Accumulation...
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Cholestérol › Diaporisoindole B Reduces Lipid Accumulation...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux lipoprotéines › Récepteurs aux lipoprotéines LDL › Récepteurs éboueurs › Diaporisoindole B Reduces Lipid Accumulation...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Transporteurs ABC › Diaporisoindole B Reduces Lipid Accumulation...