OXPHOS promotes apoptotic resistance and cellular persistence in T


Journal

Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624

Informations de publication

Date de publication:
25 11 2022
Historique:
entrez: 18 11 2022
pubmed: 19 11 2022
medline: 23 11 2022
Statut: ppublish

Résumé

T cell proliferation and cytokine production are bioenergetically and biosynthetically costly. The inability to meet these metabolic demands results in altered differentiation, accompanied by impaired effector function, and attrition of the immune response. Interleukin-17-producing CD4 T cells (T

Identifiants

pubmed: 36399539
doi: 10.1126/sciimmunol.abm8182
pmc: PMC9853437
mid: NIHMS1861567
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabm8182

Subventions

Organisme : NCI NIH HHS
ID : R01 CA244827
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA046592
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE026728
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK097153
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA140044
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK094775
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007413
Pays : United States
Organisme : NCI NIH HHS
ID : R37 CA237421
Pays : United States

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Auteurs

Hanna S Hong (HS)

Graduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA.
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.

Nneka E Mbah (NE)

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.

Mengrou Shan (M)

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.

Kristen Loesel (K)

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
Graduate Program in Cancer Biology, University of Michigan, Ann Arbor, MI 48109, USA.

Lin Lin (L)

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.

Peter Sajjakulnukit (P)

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
Graduate Program in Cancer Biology, University of Michigan, Ann Arbor, MI 48109, USA.

Luis O Correa (LO)

Graduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA.

Anthony Andren (A)

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.

Jason Lin (J)

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.

Atsushi Hayashi (A)

Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

Brian Magnuson (B)

Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.

Judy Chen (J)

Graduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA.

Zhaoheng Li (Z)

Department of Computational Mathematics, Science and Engineering, Michigan State University, East Lansing, MI 48824, USA.

Yuying Xie (Y)

Department of Computational Mathematics, Science and Engineering, Michigan State University, East Lansing, MI 48824, USA.

Li Zhang (L)

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.

Daniel R Goldstein (DR)

Institute of Gerontology, Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA.

Shannon A Carty (SA)

Graduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA.
Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.

Yu Leo Lei (YL)

Graduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA.
Graduate Program in Cancer Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109, USA.

Anthony W Opipari (AW)

Department of Obstetrics and Gynecology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.

Rafael J Argüello (RJ)

Aix Marseille Univ, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Marseille, France.

Ilona Kryczek (I)

Graduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA.
Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.

Nobuhiko Kamada (N)

Graduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA.
Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.

Weiping Zou (W)

Graduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA.
Graduate Program in Cancer Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.

Luigi Franchi (L)

Graduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA.
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.

Costas A Lyssiotis (CA)

Graduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA.
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
Graduate Program in Cancer Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.

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