Urinary volatile organic compound metabolites and reduced lung function in U.S. adults.
Lung function
Spirometry
Urinary metabolites
Volatile organic compounds
Journal
Respiratory medicine
ISSN: 1532-3064
Titre abrégé: Respir Med
Pays: England
ID NLM: 8908438
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
13
09
2022
revised:
07
11
2022
accepted:
09
11
2022
pubmed:
19
11
2022
medline:
15
12
2022
entrez:
18
11
2022
Statut:
ppublish
Résumé
Volatile organic compounds (VOCs) are associated with adverse respiratory outcomes at high occupational exposures. However, whether exposure levels found in the general population have similar effects is unknown. We analyzed data on 1342 adult participants in the 2011-2012 National Health and Nutrition Examination Survey aged ≥18 years old who had urinary VOC metabolites and spirometry measurements available. Linear regression models adjusting for covariates were fitted to estimate the associations of VOC exposures levels and spirometry outcomes, while accounting for survey design and sampling weights to generate nationally representative estimates. The urinary metabolites for xylene, acrylamide, acrolein, 1,3-butadiene, cyanide, toluene, 1-bromopropane, acrylonitrile, propylene oxide, styrene, ethylbenzene, and crotonaldehyde in our analysis were all detected in >75% of participants. Forced expiratory volume in 1 s (FEV This is the first study of a representative sample of the U.S. adult population to reveal associations of acrylonitrile, propylene oxide, and styrene urinary metabolites with reduced lung function at non-occupational exposures. Results also support previous evidence of acrylamide and acrolein's association with adverse respiratory outcomes.
Sections du résumé
BACKGROUND
Volatile organic compounds (VOCs) are associated with adverse respiratory outcomes at high occupational exposures. However, whether exposure levels found in the general population have similar effects is unknown.
METHODS
We analyzed data on 1342 adult participants in the 2011-2012 National Health and Nutrition Examination Survey aged ≥18 years old who had urinary VOC metabolites and spirometry measurements available. Linear regression models adjusting for covariates were fitted to estimate the associations of VOC exposures levels and spirometry outcomes, while accounting for survey design and sampling weights to generate nationally representative estimates.
RESULTS
The urinary metabolites for xylene, acrylamide, acrolein, 1,3-butadiene, cyanide, toluene, 1-bromopropane, acrylonitrile, propylene oxide, styrene, ethylbenzene, and crotonaldehyde in our analysis were all detected in >75% of participants. Forced expiratory volume in 1 s (FEV
CONCLUSIONS
This is the first study of a representative sample of the U.S. adult population to reveal associations of acrylonitrile, propylene oxide, and styrene urinary metabolites with reduced lung function at non-occupational exposures. Results also support previous evidence of acrylamide and acrolein's association with adverse respiratory outcomes.
Identifiants
pubmed: 36399896
pii: S0954-6111(22)00318-3
doi: 10.1016/j.rmed.2022.107053
pmc: PMC9869342
mid: NIHMS1850816
pii:
doi:
Substances chimiques
Volatile Organic Compounds
0
propylene oxide
Y4Y7NYD4BK
Acrylamide
20R035KLCI
Styrene
44LJ2U959V
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
107053Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL132344
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES027815
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES034049
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES006096
Pays : United States
Organisme : NIEHS NIH HHS
ID : R21 ES032161
Pays : United States
Organisme : NIDA NIH HHS
ID : K01 DA044313
Pays : United States
Organisme : NHGRI NIH HHS
ID : R01 HG011411
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors have no conflict of interest to disclose.
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