A re-appraisal of mesenchymal-epithelial transition (MET) in endometrial epithelial remodeling.
Endometrial epithelial remodeling
Endometrial regeneration
Epithelial repair
Mesenchymal-epithelial transition (MET)
Postnatal uterine maturation
Journal
Cell and tissue research
ISSN: 1432-0878
Titre abrégé: Cell Tissue Res
Pays: Germany
ID NLM: 0417625
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
21
06
2022
accepted:
08
11
2022
pubmed:
19
11
2022
medline:
3
2
2023
entrez:
18
11
2022
Statut:
ppublish
Résumé
Mesenchymal-epithelial transition (MET) is a mechanism of endometrial epithelial regeneration. It is also implicated in adenocarcinoma and endometriosis. Little is known about this process in normal uterine physiology. Previously, using pregnancy and menses-like mouse models, MET occurred only as an epithelial damage/repair mechanism. Here, we hypothesized that MET also occurs in other physiological endometrial remodeling events, outside of damage/repair, such as during the estrous cycle and adenogenesis (gland development). To investigate this, Amhr2-Cre-YFP/GFP mesenchyme-specific reporter mice were used to track the fate of mesenchymal-derived (MD) cells. Using EpCAM (epithelial marker), EpCAM
Identifiants
pubmed: 36401092
doi: 10.1007/s00441-022-03711-z
pii: 10.1007/s00441-022-03711-z
pmc: PMC9889438
mid: NIHMS1864147
doi:
Substances chimiques
Epithelial Cell Adhesion Molecule
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
393-408Subventions
Organisme : NICHD NIH HHS
ID : R01 HD102476
Pays : United States
Organisme : National Institute of Child Health and Human Development
ID : R01HD102476
Informations de copyright
© 2022. The Author(s).
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