Molecular characterization and clinical impact of human bocavirus at a tertiary hospital in Barcelona (Catalonia, Spain) during the 2014-2017 seasons.
Clinical impact
Human bocavirus
Molecular characterization
Surveillance
Journal
Infection
ISSN: 1439-0973
Titre abrégé: Infection
Pays: Germany
ID NLM: 0365307
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
received:
31
08
2022
accepted:
06
11
2022
medline:
19
7
2023
pubmed:
20
11
2022
entrez:
19
11
2022
Statut:
ppublish
Résumé
The aim was to describe the prevalence, molecular epidemiology and clinical manifestations of human bocavirus (HBoV) in patients attended at a tertiary hospital in Barcelona, Spain. From October 2014 to May 2017, respiratory specimens from paediatric patients were collected for respiratory viruses' laboratory-confirmation. Phylogenetic analyses from partial VP1 sequences were performed from all HBoV laboratory-confirmed specimens. Clinical features were retrospectively studied. 178/10271 cases were HBoV laboratory-confirmed. The median age was 1.53 (IQR 1.0-2.3). Co-detection was highly reported (136; 76%). All viruses belonged into HBoV1 genotype but one into HBoV2. Non-reported mutations were observed and two sites were suggestive to be under negative selection. 61% (109/178) cases had lower RTI (LRTI), of whom 84 had co-detections (77%) and 76 had comorbidities (70%). LRTI was the cause of hospitalization in 85 out of 109 cases (78%), and no differences were found regarding severity factors during hospitalization between co- and single-detections, except for median length of respiratory support, which was longer in cases with co-detections. Close monitoring of predominant HBoV1 showed a high similarity between viruses. The presence of comorbidities might explain the high prevalence of LRTI. Symptomatology in HBoV single-detected cases suggest that HBoV is a true pathogen.
Identifiants
pubmed: 36401674
doi: 10.1007/s15010-022-01955-z
pii: 10.1007/s15010-022-01955-z
pmc: PMC9676756
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
935-943Subventions
Organisme : Instituto de Salud Carlos III
ID : REIPI RD16/0016/0003
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
Références
Guido M, Tumolo MR, Verri T, Romano A, Serio F, De Giorgi M, et al. Human bocavirus: current knowledge and future challenges. World J Gastroenterol. 2016;22:8684.
doi: 10.3748/wjg.v22.i39.8684
pubmed: 27818586
pmcid: 5075545
Allander T, Tammi MT, Eriksson M, Bjerkner A, Tiveljung-Lindell A, Andersson B. Cloning of a human parvovirus by molecular screening of respiratory tract samples. Proc Natl Acad Sci USA. 2005;102:12891–6.
doi: 10.1073/pnas.0504666102
pubmed: 16118271
pmcid: 1200281
Cotmore SF, Agbandje-McKenna M, Chiorini JA, Gatherer D, Mukha D V, Pintel DJ, et al. Rationalization and extension of the taxonomy of the family Parvoviridae. ICTV. 2013. 1–18.
Kapoor A, Slikas E, Simmonds P, Chieochansin T, Shaukat S, Alam MM, et al. A new bocavirus species in human stool. J Infect Dis. 2009;199:196–200.
doi: 10.1086/595831
pubmed: 19072716
Pogka V, Moutousi A, Kossyvakis A, Kalliaropoulos A, Sgouras DN, Giannaki M, et al. Genetic variability of human metapneumo- and bocaviruses in children with respiratory tract infections. Influenza Other Respi Viruses. 2014;8:107–15.
doi: 10.1111/irv.12185
Kenmoe S, Vernet M-A, Njankouo-Ripa M, Penlap VB, Vabret A, Njouom R. Phylogenic analysis of human bocavirus detected in children with acute respiratory infection in Yaounde, Cameroon. BMC Res Notes BioMed Central. 2017;10:293.
doi: 10.1186/s13104-017-2620-y
Moesker FM, van Kampen JJA, van der Eijk AA, van Rossum AMC, de Hoog M, Schutten M, et al. Human bocavirus infection as a cause of severe acute respiratory tract infection in children. Clin Microbiol Infect Elsevier Ltd. 2015;21:964.e1-8.
doi: 10.1016/j.cmi.2015.06.014
Mietzsch M, Kailasan S, Garrison J, Ilyas M, Chipman P, Kantola K, et al. Structural insights into human bocaparvoviruses. J Virol. 2017;91.
Qiu J, Söderlund-Venermo M, Young NS. Human parvoviruses. Clin Microbiol Rev. 2017;30:43–113.
doi: 10.1128/CMR.00040-16
pubmed: 27806994
Jartti T, Hedman K, Jartti L, Ruuskanen O, Allander T, Söderlund-Venermo M. Human bocavirus—the first 5 years. Rev Med Virol. 2012;22:46–64.
doi: 10.1002/rmv.720
pubmed: 22038931
Martin ET, Fairchok MP, Kuypers J, Magaret A, Zerr DM, Wald A, et al. Frequent and prolonged shedding of bocavirus in young children attending daycare. J Infect Dis. 2010;201:1625–32.
doi: 10.1086/652405
pubmed: 20415535
Kapoor A, Simmonds P, Slikas B, Li L, Bodhidatta L, Sethabutr O, et al. Humn bocaviruses are highly diverse, dispersed, recombination prone, and prevalent enteric infections. J Infect Dis. 2010;201:1633–43.
doi: 10.1086/652416
pubmed: 20415538
Tamura K, Stecher G, Peterson D, Filipski A, Kumar S. MEGA6: molecular evolutionary genetics analysis version 6.0. Mol Biol Evol. 2013;30:2725–9.
doi: 10.1093/molbev/mst197
pubmed: 24132122
pmcid: 3840312
Glez-Peña D, Gómez-Blanco D, Reboiro-Jato M, Fdez-Riverola F, Posada D. ALTER: Program-oriented conversion of DNA and protein alignments. Nucleic Acids Res. 2010;38:14–8.
doi: 10.1093/nar/gkq321
Delport W, Poon AFY, Frost SDW, Kosakovsky Pond SL. Datamonkey 2010: a suite of phylogenetic analysis tools for evolutionary biology. Bioinformatics. 2010;26:2455–7.
doi: 10.1093/bioinformatics/btq429
pubmed: 20671151
pmcid: 2944195
Kosakovsky Pond SL, Frost SDWW. Not so different after all: a comparison of methods for detecting amino acid sites under selection. Mol Biol Evol. 2005;22:1208–22.
doi: 10.1093/molbev/msi105
pubmed: 15703242
Murrell B, Wertheim JO, Moola S, Weighill T, Scheffler K, Kosakovsky Pond SL. Detecting individual sites subject to episodic diversifying selection. Malik HS, editor. PLoS Genet. 2012;8:e1002764.
doi: 10.1371/journal.pgen.1002764
pubmed: 22807683
pmcid: 3395634
Dina J, Vabret A, Gouarin S, Petitjean J, Lecoq J, Brouard J, et al. Detection of human bocavirus in hospitalised children. J Paediatr Child Health. 2009;45:149–53.
doi: 10.1111/j.1440-1754.2008.01442.x
pubmed: 19210599
pmcid: 7167115
Bastien N, Brandt K, Dust K, Ward D, Li Y. Human bocavirus infection. Canada Emerg Infect Dis. 2006;12:848–50.
doi: 10.3201/eid1205.051424
pubmed: 16704852
Shen J, Zhu Q, Zeng M, Yu H. Detection and genome analysis of human bocavirus 1–4 from hospitalized children with acute lower respiratory tract infection and symptoms of wheezing in Shanghai. Int J Mol Med. 2013;32:1415–20.
doi: 10.3892/ijmm.2013.1512
pubmed: 24085194
Kesebir D, Vazquez M, Weibel C, Shapiro ED, Ferguson D, Landry ML, et al. Human bocavirus infection in young children in the United States: molecular epidemiological profile and clinical characteristics of a newly emerging respiratory virus. J Infect Dis. 2006;194:1276–82.
doi: 10.1086/508213
pubmed: 17041854
Moreno B, Abrego L, Carrera J-P, Franco D, Gaitán M, Castillo J, et al. Detection of human bocavirus type 1 infection in Panamanian children with respiratory illness. J Med Virol. 2016;88:389–94.
doi: 10.1002/jmv.24346
pubmed: 26252655
Arnott A, Vong S, Rith S, Naughtin M, Ly S, Guillard B, et al. Human bocavirus amongst an all-ages population hospitalised with acute lower respiratory infections in Cambodia. Influenza Other Respi Viruses. 2013;7:201–10.
doi: 10.1111/j.1750-2659.2012.00369.x
Antón A, Marcos M, Torner N, Isanta R, Camps M, Martínez A, et al. Virological surveillance of influenza and other respiratory viruses during six consecutive seasons from 2006 to 2012 in Catalonia. Spain Clin Microbiol Infect Elsevier Ltd. 2016;22:1–9.
Schildgen O, Müller A, Allander T, Mackay IM, Völz S, Kupfer B, et al. Human bocavirus: passenger or pathogen in acute respiratory tract infections? Clin Microbiol Rev. 2008;21:291–304.
doi: 10.1128/CMR.00030-07
pubmed: 18400798
pmcid: 2292574
Streiter M, Malecki M, Prokop A, Schildgen V, Lüsebrink J, Guggemos A, et al. Does human bocavirus infection depend on helper viruses? A challenging case report. Virol J BioMed Central Ltd. 2011;8:417.
Wang Z, Deng X, Zou W, Engelhardt JF, Yan Z, Qiu J. Human bocavirus 1 is a novel helper for adeno-associated virus replication. J Virol. 2017;91:1–18.
doi: 10.1128/JVI.00710-17
Kalyanaraman N. In silico prediction of potential vaccine candidates on capsid protein of human bocavirus 1. Mol Immunol Elsevier. 2017;93:193–205.
doi: 10.1016/j.molimm.2017.11.024
Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, et al. The Protein Data Bank. Nucleic Acids Res. 2000;28:235–42.
doi: 10.1093/nar/28.1.235
pubmed: 10592235
pmcid: 102472
Williams JV. Déjà Vu All Over Again: Koch’s Postulates and Virology in the 21st Century. J Infect Dis. 2010;201:1611–4.
doi: 10.1086/652406
pubmed: 20415534
Andrés C, Vila J, Creus-Costa A, Piñana M, González-Sánchez A, Esperalba J, et al. Enterovirus D68 in Hospitalized Children, Barcelona, Spain, 2014–2021. Emerg Infect Dis [Internet]. 2022;28:1327–31. https://wwwnc.cdc.gov/eid/article/28/7/22-0264_article.htm
Piñana M, Vila J, Maldonado C, Galano-Frutos JJ, Valls M, Sancho J, et al. Insights into immune evasion of human metapneumovirus: novel 180- and 111-nucleotide duplications within viral G gene throughout 2014–2017 seasons in Barcelona. Spain J Clin Virol. 2020;132:104590.
doi: 10.1016/j.jcv.2020.104590
pubmed: 32957052