A trans-omics assessment of gene-gene interaction in early-stage NSCLC.

Humans Carcinoma, Non-Small-Cell Lung / drug therapy Lung Neoplasms / metabolism DNA Methylation / genetics Small Cell Lung Carcinoma / genetics Epigenome
G × G interactions NSCLC overall survival prognosis trans-omics

Journal

Molecular oncology
ISSN: 1878-0261
Titre abrégé: Mol Oncol
Pays: United States
ID NLM: 101308230

Informations de publication

Date de publication:
01 2023
Historique:
revised: 28 08 2022
received: 13 06 2022
accepted: 17 11 2022
pubmed: 22 11 2022
medline: 7 1 2023
entrez: 21 11 2022
Statut: ppublish

Résumé

Epigenome-wide gene-gene (G × G) interactions associated with non-small-cell lung cancer (NSCLC) survival may provide insights into molecular mechanisms and therapeutic targets. Hence, we proposed a three-step analytic strategy to identify significant and robust G × G interactions that are relevant to NSCLC survival. In the first step, among 49 billion pairs of DNA methylation probes, we identified 175 775 G × G interactions with P

Identifiants

DOI: 10.1002/1878-0261.13345 PMID: 36408734 PMC: PMC9812838
pubmed: 36408734
doi: 10.1002/1878-0261.13345
pmc: PMC9812838
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

173-187

Subventions

Organisme : US National Institutes of Health
ID : CA249096
Organisme : NCI NIH HHS
ID : R35 CA197449
Pays : United States
Organisme : US National Institutes of Health
ID : CA209414
Organisme : US National Institutes of Health
ID : ES000002
Organisme : US National Institutes of Health
ID : CA092824

Informations de copyright

© 2022 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.

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Auteurs

Jiajin Chen (J)

Department of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.

Yunjie Song (Y)

Department of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.

Yi Li (Y)

Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.

Yongyue Wei (Y)

Department of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
China International Cooperation Center for Environment and Human Health, Nanjing Medical University, Nanjing, China.

Sipeng Shen (S)

Department of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.

Yang Zhao (Y)

Department of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.

Dongfang You (D)

Department of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.

Li Su (L)

Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Pulmonary and Critical Care Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Maria Moksnes Bjaanaes (MM)

Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.
ORCID: 0000-0001-7126-9064

Anna Karlsson (A)

Division of Oncology, Department of Clinical Sciences Lund and CREATE Health Strategic Center for Translational Cancer Research, Lund University, Lund, Sweden.

Maria Planck (M)

Division of Oncology, Department of Clinical Sciences Lund and CREATE Health Strategic Center for Translational Cancer Research, Lund University, Lund, Sweden.

Johan Staaf (J)

Division of Oncology, Department of Clinical Sciences Lund and CREATE Health Strategic Center for Translational Cancer Research, Lund University, Lund, Sweden.

Åslaug Helland (Å)

Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.
Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Manel Esteller (M)

Josep Carreras Leukaemia Research Institute, Barcelona, Spain.
Centro de Investigacion Biomedica en Red Cancer, Madrid, Spain.
Institucio Catalana de Recerca i Estudis Avançats, Barcelona, Spain.
Physiological Sciences Department, School of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain.
ORCID: 0000-0003-4490-6093

Hongbing Shen (H)

China International Cooperation Center for Environment and Human Health, Nanjing Medical University, Nanjing, China.
Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China.
Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China.

David C Christiani (DC)

Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Pulmonary and Critical Care Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Ruyang Zhang (R)

Department of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
China International Cooperation Center for Environment and Human Health, Nanjing Medical University, Nanjing, China.
ORCID: 0000-0003-3861-4297

Feng Chen (F)

Department of Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
China International Cooperation Center for Environment and Human Health, Nanjing Medical University, Nanjing, China.
Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China.
State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A trans-omics assessment of gene-gene...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Tumeurs des bronches › Carcinome bronchogénique › Carcinome pulmonaire non à petites cellules › A trans-omics assessment of gene-gene...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › A trans-omics assessment of gene-gene...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › A trans-omics assessment of gene-gene...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Tumeurs des bronches › Carcinome bronchogénique › Carcinome pulmonaire à petites cellules › A trans-omics assessment of gene-gene...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Épigénome › A trans-omics assessment of gene-gene...