Developing a new sepsis screening tool based on lymphocyte count, international normalized ratio and procalcitonin (LIP score).
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
21 11 2022
21 11 2022
Historique:
received:
17
03
2022
accepted:
14
07
2022
entrez:
21
11
2022
pubmed:
22
11
2022
medline:
24
11
2022
Statut:
epublish
Résumé
Exploring an effective sepsis screening tool that can be widely implemented is important for improving the prognosis of sepsis worldwide. This study aimed to develop a new simple screening tool for sepsis (LIP scoring system) that includes the peripheral blood lymphocyte count, international normalized ratio, and procalcitonin level. In a single-center, prospective, observational study, 444 acute sepsis inpatients and 444 nonsepsis inpatients were ultimately included based on the Sepsis-3 and exclusion criteria. The differences in the Lym, INR, PCT level and other clinical biomarkers were compared between the two groups. Univariable and multivariable logistic regression analyses and receiver operating characteristic analysis were used to establish a LIP screening tool for sepsis with a combination of biomarkers. The Kappa and McNemar tests were used to evaluate the differences between the LIP screening results (LIP score ≥ 3) and Sepsis-3 criteria (SOFA score ≥ 2). Logistic regression analysis showed that the lymphocyte count, INR, PCT level, platelets, neutrophil/lymphocyte ratio (NLR) and prothrombin time (PT) were independent risk factors for the development of sepsis. The ROC analysis showed that the lymphocyte count, INR, and PCT level had high area under the ROC curve values (AUROC (95% CI): Lym 0.84 (0.810-0.860), INR 0.921 (0.902-0.938), PCT level 0.928 (0.909-0.944)). The LIP tool had satisfactory screening efficacy for sepsis (sensitivity, 92.8%; specificity, 94.1%), and a LIP score equal to or greater than 3 points had good agreement with Sepsis-3 criteria in the diagnosis of sepsis (Kappa = 0862 in the Kappa test and P = 0.512 in the McNemar test). The LIP tool has satisfactory sensitivity and specificity for sepsis screening, and it can be used for rapid screening of patients with sepsis in outpatient and emergency departments or in economically underdeveloped areas with limited resources.
Identifiants
pubmed: 36411279
doi: 10.1038/s41598-022-16744-9
pii: 10.1038/s41598-022-16744-9
pmc: PMC9678875
doi:
Substances chimiques
Procalcitonin
0
Biomarkers
0
Types de publication
Observational Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
20002Subventions
Organisme : Chongqing Medical Scientific Research Project (Joint Project of Chongqing Health Commission and Science and Technology Bureau)
ID : 2021MSXM033
Organisme : Chongqing Medical Scientific Research Project (Joint Project of Chongqing Health Commission and Science and Technology Bureau)
ID : 2019MSXM019
Organisme : Chongqing Natural Science Foundation Project
ID : cstc2020jcyj-msxmX0124
Organisme : COVID-19 Emergency Projects of Chongqing Medical University
ID : X1-2611
Informations de copyright
© 2022. The Author(s).
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